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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
KLK3
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "KLK3" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: 11-KDHT; 5α-Dihydro-11-keto testosterone
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11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells .
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Cat. No.: HY-RS07381
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KLK3 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-168201
CAS No.: 3105406-14-9
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MJP6412 is a p300 and CBP PROTAC degrader that potently degrades p300 and CBP in 22Rv1 cells with DC50 values of 1.6 nM and 1.2 nM, respectively. MJP6412 downregulates the expression of AR-FL, AR-V7 and c-MYC, as well as androgen receptor target genes (KLK3, FKBP5, TMPRSS2). MJP6412 completely abolishes p300/CBP-dependent histone acetylation (H3K27Ac and H2BNTAC) and induces G1 cell cycle arrest. MJP6412 inhibits cancer cell proliferation and tumor growth. MJP6412 can be used in prostate cancer-related research .
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AR antagonist 3 is a potent and selective androgen receptor (AR) antagonist with an IC50 of 0.47 µM. AR antagonist 3 exhibits a dose-dependent decrease of the FRET signal (IC50= 18.05 μM). AR antagonist 3 shows effective inhibition on tumor growth when administered intratumorally .
Cat. No.: HY-135794R
CAS No.: 32694-37-4
Synonyms: 11-KDHT (Standard); 5α-Dihydro-11-keto testosterone (Standard)
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11-Ketodihydrotestosterone (Standard) is the analytical standard of 11-Ketodihydrotestosterone. This product is intended for research and analytical applications. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells .
Cat. No.: HY-181971
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XY25028 is an orally active LRH-1 inhibitor with an IC50 of 0.30 μM. XY25028 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells and suppresses the expression of AR target genes KLK2 and KLK3. XY25028 can be used in the research of castration-resistant prostate cancer .
Cat. No.: HY-181970
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XY25026 is an orally active LRH-1 inhibitor with an IC50 of 0.28 μM. XY25026 inhibits the proliferation of androgen receptor (AR)-positive prostate cancer cells, suppresses the expression of AR target genes KLK2 and KLK3, and inhibits tumor growth in xenograft models. XY25026 is applicable to the research of castration-resistant prostate cancer .
Cat. No.: HY-P700772
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin
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Cat. No.: HY-P77973A
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin
Cat. No.: HY-P70249A
Purity: ≥ 95% as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: Plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin
Cat. No.: HY-P71748
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLKb1; KLK3; PkPlasma kallikrein; EC 3.4.21.34; Fletcher factor; Kininogenin
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Source:
Cat. No.: HY-P70606A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Prostate-specific antigen; PSA; Gamma-seminoprotein; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APS
Cat. No.: HY-183667
CAS No.: 1332390-06-3
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JNJ-pan-AR is an orally active androgen receptor (AR) inhibitor with an IC50 of 19 nM and a Ki of 8.4 nM against human wild-type AR. JNJ-pan-AR abolishes androgen-induced KLK2 and KLK3 mRNA expression and reduces androgen-dependent colony formation in prostate cancer cells. JNJ-pan-AR blocks AR nuclear translocation, inhibits PSA protein expression, and represses the growth of AR-dependent tumor cells and ARF877L-driven tumor xenografts. JNJ-pan-AR blocks transactivation and signaling of wild-type AR and various mutant AR variants. JNJ-pan-AR is applicable for research on castration-resistant prostate cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
