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Results for "

NAADP

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131614
    TPC2-A1-N
    5+ Cited Publications

    		 Calcium Channel Others
    TPC2-A1-N is a powerful and Ca 2+-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca 2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells .
    TPC2-A1-N
  • HY-103317A
    NAADP tetrasodium

    		Calcium Channel Cardiovascular Disease Cancer
    NAADP tetrasodium is a second messenger. NAADP tetrasodium releases Ca 2+ from acidic endosomes and lysosomes. NAADP tetrasodium can be used to study cancer (such as oral squamous cell carcinoma, malignant melanoma) and angiogenesis-related diseases .
    NAADP tetrasodium
  • HY-131615
    TPC2-A1-P
    4 Publications Verification

    		 Sodium Channel Others
    TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na 2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells .
    TPC2-A1-P
  • HY-103317
    NAADP

    		Nucleoside Antimetabolite/Analog Inflammation/Immunology
    NAADP, a nucleotide, is a Ca 2+-mobilizing second messenger. NAADP is essential for initiation of Ca 2+ signaling .
    NAADP
  • HY-103316
    trans-Ned 19

    		Calcium Channel Cardiovascular Disease Inflammation/Immunology
    trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis .
    trans-Ned 19
  • HY-154924
    Thio-NADP

    S-NADP

    		 Calcium Channel Cardiovascular Disease
    Thio-NADP (S-NADP) is a nicotinic acid adenine dinucleotide phosphate (NAADP) inhibitor. Thio-NADP activates partial Ca 2+ release .
    Thio-NADP
  • HY-103316A
    Ned 19
    3 Publications Verification

    		 Calcium Channel Cardiovascular Disease Cancer
    Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca 2+ signaling, with an IC50 of 65 nM . Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice .
    Ned 19
  • HY-108960
    PPADS

    		P2X Receptor Interleukin Related Neurological Disease
    PPADS is a P2X receptor (P2X Receptor) antagonist and a reversible competitive antagonist of NAADP receptors, with IC50 values of 68 nM (P2X1) and 214 nM (P2X3), respectively. PPADS alleviates pain-related behaviors in the central and peripheral nervous systems of mice after peripheral neuropathy, inhibits the overproduction of IL-1β, IL-6, iNOS and nNOS, and suppresses the hydrolytic activity of extracellular ATPase. PPADS blocks ATP-mediated inward currents on recombinant rat P2X1 and P2X3 receptors, and inhibits purinergic nerve stimulation-induced contraction of rabbit bladder detrusor muscle. PPADS is applicable to research related to neuropathic pain .
    PPADS
  • HY-103305
    cis-Ned19

    		Fluorescent Dye Calcium Channel Others
    cis-Ned19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. cis-Ned19 localizes to lysosomes and endolysosomal vesicles, stains two-pore calcium channels and fluorescently labels NAADP receptors (Ex/Em = 365/410 nm) .
    cis-Ned19
  • HY-172321
    Etheno-NAADP sodium

    Nicotinic acid 1,N6-ethenoadenine dinucleotide phosphate sodium

    		 Fluorescent Dye Others
    Etheno-NAADP (Nicotinic acid 1,N6-ethenoadenine dinucleotide phosphate) sodium is a fluorescent product of NAADP (HY-103317). Etheno-NAADP sodium could activate Ca 2+ release from sea urchin egg homogenates with an EC50 of 5 µM (Ex/Em = 275/410 nm) .
    Etheno-NAADP sodium
  • HY-121253
    NAADP receptor modulator-1

    		Calcium Channel Others
    NAADP receptor modulator-1 is a cell-permeable NAADP receptor modulator. NAADP receptor modulator-1 competes with NAADP for binding sites and inhibits NAADP-induced Ca 2+ release .
    NAADP receptor modulator-1
  • HY-131041
    Ned-K

    		Calcium Channel Cardiovascular Disease
    Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca 2+ oscillations in cardiomyocytes .
    Ned-K
  • HY-103316R
    trans-Ned 19 (Standard)

    		Reference Standards Calcium Channel Cardiovascular Disease Inflammation/Immunology
    trans-Ned 19 (Standard) is the analytical standard of trans-Ned 19 (HY-103316). This product is intended for research and analytical applications. trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis .
    trans-Ned 19 (Standard)

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