10 Results for "

NNK

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "NNK" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-126477
CAS No.: 64091-91-4
Purity:  99.98%
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser 70 and c-Myc at Thr 58 and Ser 62 through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .
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Cat. No.: HY-126477S
CAS No.: 764661-24-7
Purity:  99.65%
Synonyms: 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone-d4
NNK-d4 is the deuterium labeled NNK .
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Cat. No.: HY-W019817
CAS No.: 76014-81-8
Synonyms: NNAL
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is the main metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. The oxidative metabolic pathway in which NNAL is oxidized to NNK and other products exhibits carcinogenic activity. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol can be used in research on carcinogenic mechanisms related to lung cancer .
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Cat. No.: HY-W679796
CAS No.: 61499-10-3
Synonyms: 4-Phenylbutyl isothiocyanate
Target:  

Drug Derivative

Research Areas:  

Cancer

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375) .
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Cat. No.: HY-126477R
CAS No.: 64091-91-4
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .
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Cat. No.: HY-126477S1
CAS No.: 86270-92-0
NNK-d3 is the deuterium labeled NNK (HY-126477) .
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Cat. No.: HY-W778275
CAS No.: 1346600-19-8
NNK- 13C6 is the 13C-labeled NNK.
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Cat. No.: HY-N14116
CAS No.: 8000-78-0
Garlic oil is an orally effective anti-inflammatory, antioxidant, and anticancer agent. Garlic oil inhibits the activation of NF-κB, NFκB2 and NLRP3 inflammasome, and induces the expression of GSTA1, HO-1 and NQO-1. Garlic oil reduces the Bcl-2/Bax protein ratio and activates NNK-induced apoptosis (apoptosis) in lung tissues. Garlic oil attenuates NNK-induced apoptosis in MRC-5 cells and reduces excessive ROS production. Garlic oil alleviates pyroptosis (pyroptosis) and exerts a protective effect against acute lung injury in mice. Garlic oil inhibits lung tumorigenesis in mice and improves small intestinal motility in rats with type 2 diabetes . Garlic oil can be used in research related to acute lung injury, lung cancer, peptic ulcer, type 2 diabetes and hypertension .
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Cat. No.: HY-173102S
LQEEIDAVL(Pro- 13C5, 15N)NK TFA is the 13C- and 15N-labeled LQEEIDAVL(Pro)NK TFA.
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Cat. No.: HY-W019817S1
CAS No.: 1020719-61-2
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-d3 is the deuterium labeled 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (HY-W019817). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is the main metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. The oxidative metabolic pathway in which NNAL is oxidized to NNK and other products exhibits carcinogenic activity. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol can be used in research on carcinogenic mechanisms related to lung cancer .
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