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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
NOD mouse
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "NOD mouse" in MCE Product Catalog:
Cat. No.: HY-W746708
CAS No.: 79335-75-4
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FK-565 is a synthetic immunomodulatory peptide with a nucleotide oligomerization domain-1 (NOD1) ligand. FK-565 can activate macrophages, NK cells, and peritoneal exudative cells, enhancing the innate immune response. FK-565 has antiviral activity against a variety of viruses in vivo, and its effect is achieved through immunomodulation rather than direct viral inhibition. FK-565 can induce mouse models of arteritis and coronary arteritis (Kawasaki disease-like disease) through a NOD1-mediated mechanism. FK-565 can be used for research on viral infections and inflammatory vascular diseases .
Cat. No.: HY-P99148
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Cat. No.: HY-175278
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BAL-1516 is an orally active NLRP3 inhibitor with human NLRP3 Kd of 14.2 nM, mouse NLRP3 Kd of 200 nM, and blood-brain barrier penetration.BAL-1516 binds to a surface groove of the NLRP3 nucleotide-binding domain, contacts FISNA and WHD subdomains, forms three hydrogen bonds to the peripheral β-strand of the triple-ATPase, and does not alter NLRP3 ATP-hydrolysis activity.BAL-1516 shows specificity for NLRP3 over other NOD-like receptors, directly binds mouse NLRP3, and inhibits inflammasome formation in monocytes and microglia .
Cat. No.: HY-RS09404
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Nod1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09407
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Nod2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P5396A
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Cat. No.: HY-170447
CAS No.: 3099180-63-6
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NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD1-induced NF-κB and MAPK pathways .
Cat. No.: HY-168137
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NOD2 agonist 2 (compound 23) enhanced the antigen presentation of mouse bone marrow-derived dendritic cells (BMDCs), highlighting its potential as a vaccine adjuvant.
Cat. No.: HY-P5396
CAS No.: 152468-44-5
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Cat. No.: HY-118912
CAS No.: 457937-39-2
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BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) . BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models .
Cat. No.: HY-184473
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NOD1/TLR7 agonist-1 is a dual NOD1 and TLR7 agonist. NOD1/TLR7 agonist-1 exhibits adjuvant effects in mouse vaccine models and induces increased ovalbumin-specific IgG titers. NOD1/TLR7 agonist-1 can be used for research on immune-related diseases .
Cat. No.: HY-184472
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NOD1 agonist-1 is a NOD1 agonist with immunostimulatory and adjuvant activities. NOD1 agonist-1 enhances ovalbumin-specific total IgG antibody responses in mouse vaccination models. NOD1 agonist-1 can be used for the research of immune-related diseases .
Cat. No.: HY-P10492
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Cat. No.: HY-181821
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MMV1581361 is a PfATP4 inhibitor and an orally active, transmission-blocking agent with nanomolar activity against Plasmodium falciparum blood-stage isolates. MMV1581361 disrupts sodium ion (Na +) homeostasis in Plasmodium falciparum. MMV1581361 inhibits male gamete exflagellation, reduces oocyst intensity, and blocks transmission of Plasmodium falciparum. MMV1581361 demonstrates efficacy in the humanized Plasmodium falciparum NOD scid IL2Rγ null mouse model. MMV1581361 can be used for the research of malaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
