NOD mouse

By Targets:	NOD-like Receptor (NLR) (4) Amino Acid Decarboxylase (2) IFNAR (1) Insulin Receptor (1) MDM-2/p53 (1) MHC (1) Na+/K+ ATPase (1) Orphan Nuclear Receptor (1) Parasite (2) Small Interfering RNA (siRNA) (2) TNF Receptor (2)
By Research Areas:	Cancer (1) Infection (2) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) siRNAs (2)

Targets Recommended: NOD-like Receptor (NLR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1745

InsB (9-23) Insulin B chain (9-23)	MHC Insulin Receptor IFNAR	Inflammation/Immunology
InsB (9-23) (Insulin B chain (9-23)) is an HLA-DQ8-restricted insulin B-chain peptide composed of amino acid residues 9-23. InsB (9-23) serves as a major MHC II class-restricted antigen. InsB (9-23) supports the recognition and activation of T cells, stimulates the secretion of IFN-γ and cytokines, and induces cross-reactive immune responses. InsB (9-23)-specific CD4 T cells can initiate diabetes . InsB (9-23) can be used in research related to type 1 diabetes and autoimmune diabetes .

HY-P99148

*Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)*	TNF Receptor	Metabolic Disease Inflammation/Immunology
Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice .

HY-175278

BAL-1516	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
BAL-1516 is an orally active NLRP3 inhibitor with human NLRP3 K_d of 14.2 nM, mouse NLRP3 K_d of 200 nM, and blood-brain barrier penetration.BAL-1516 binds to a surface groove of the NLRP3 nucleotide-binding domain, contacts FISNA and WHD subdomains, forms three hydrogen bonds to the peripheral β-strand of the triple-ATPase, and does not alter NLRP3 ATP-hydrolysis activity.BAL-1516 shows specificity for NLRP3 over other NOD-like receptors, directly binds mouse NLRP3, and inhibits inflammasome formation in monocytes and microglia .

HY-RS09404

Nod1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) NOD-like Receptor (NLR)	Others
Nod1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nod1 Mouse Pre-designed siRNA Set A Nod1 Mouse Pre-designed siRNA Set A

HY-RS09407

Nod2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nod2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nod2 Mouse Pre-designed siRNA Set A Nod2 Mouse Pre-designed siRNA Set A

HY-P5396A

GAD65 (524-543) acetate	Amino Acid Decarboxylase	Others
GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-P10399

KGYY15 mouse KGYY15; KGYY15 peptide	TNF Receptor	Metabolic Disease
KGYY15 (Mouse KGYY15) is a CD40 targeting peptide, which weakly inhibits the CD40-CD40L interaction with IC₅₀ of more than 1mM. KGYY15 activates 33% NF-κB pathway at 100 μM .

HY-P5396

GAD65 (524-543)	Amino Acid Decarboxylase	Others
GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-170447

NOD1 antagonist-2	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse *NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD*1-induced NF-κB and MAPK pathways .

HY-168137

NOD2 agonist 2	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 agonist 2 (compound 23) enhanced the antigen presentation of mouse bone marrow-derived dendritic cells (BMDCs), highlighting its potential as a vaccine adjuvant.

HY-158776

SLU-10482	Parasite	Infection
SLU-10482 is an orally active anti-parasitic agent, that inhibits Cryptosporidium parvum with an IC₅₀ of 0.0687 μM. SLU-10482 exhibits anti-infective efficacy in C. parvum infected mice with an AC₅₀ of 0.0686 μM .

HY-118912

BMH-9	Orphan Nuclear Receptor MDM-2/p53	Inflammation/Immunology Cancer
BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) . BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models .

HY-181821

MMV1581361	Parasite Na+/K+ ATPase	Infection
MMV1581361 is a PfATP4 inhibitor and an orally active, transmission-blocking agent with nanomolar activity against Plasmodium falciparum blood-stage isolates. MMV1581361 disrupts sodium ion (Na ⁺) homeostasis in Plasmodium falciparum. MMV1581361 inhibits male gamete exflagellation, reduces oocyst intensity, and blocks transmission of Plasmodium falciparum. MMV1581361 demonstrates efficacy in the humanized Plasmodium falciparum NOD scid IL2Rγ ^null mouse model. MMV1581361 can be used for the research of malaria .

Cat. No.	Product Name	Target	Research Area

HY-P1745

InsB (9-23) Insulin B chain (9-23)	MHC Insulin Receptor IFNAR	Inflammation/Immunology
InsB (9-23) (Insulin B chain (9-23)) is an HLA-DQ8-restricted insulin B-chain peptide composed of amino acid residues 9-23. InsB (9-23) serves as a major MHC II class-restricted antigen. InsB (9-23) supports the recognition and activation of T cells, stimulates the secretion of IFN-γ and cytokines, and induces cross-reactive immune responses. InsB (9-23)-specific CD4 T cells can initiate diabetes . InsB (9-23) can be used in research related to type 1 diabetes and autoimmune diabetes .

HY-P5396A

GAD65 (524-543) acetate	Amino Acid Decarboxylase	Others
GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-P10399

KGYY15 mouse KGYY15; KGYY15 peptide	TNF Receptor	Metabolic Disease
KGYY15 (Mouse KGYY15) is a CD40 targeting peptide, which weakly inhibits the CD40-CD40L interaction with IC₅₀ of more than 1mM. KGYY15 activates 33% NF-κB pathway at 100 μM .

HY-P5396

GAD65 (524-543)	Amino Acid Decarboxylase	Others
GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-P10492

Tregitope 289	Peptides	Others Metabolic Disease
Tregitope 289 is a peptide derived from the Fc region of immunoglobulin G (IgG) and is a highly conserved T cell epitope that stimulates the expansion of natural regulatory T cells. Co-delivery of Tregitope 289 with type 1 diabetes (T1D) antigens delays the development of hyperglycemia and reduces the incidence of diabetes in the NOD mouse model. Tregitope 289 can be used to study T1D and other autoimmune diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99148

*Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)*	TNF Receptor	Metabolic Disease Inflammation/Immunology
Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice .

Cat. No.	Product Name		Classification

HY-RS09404

Nod1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nod1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09407

Nod2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nod2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nod2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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