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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Nav1.3
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Nav1.3" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-16787
CAS No.: 313254-51-2
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ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM).
Cat. No.: HY-N1847
CAS No.: 21913-98-4
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Cat. No.: HY-155058
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Nav1.3 channel inhibitor 1 (compound 15b) is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM). Nav1.3 channel inhibitor 1 can penetrate the blood-brain barrier and can be used in the research of nervous system diseases .
Cat. No.: HY-P1220A
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Cat. No.: HY-P1218B
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Cat. No.: HY-P5152
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Cat. No.: HY-P1218
CAS No.: 880886-00-0
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Cat. No.: HY-P1220
CAS No.: 526224-73-7
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Cat. No.: HY-P5795
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Cat. No.: HY-123833
CAS No.: 2153474-85-0
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PF-05661014, a desmethyl analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing inactivated channels via interaction with D4 VSD. PF-05661014 can be used for research of sodium channel modulation .
Cat. No.: HY-P1218A
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Cat. No.: HY-P5793
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Cat. No.: HY-162757
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Anticonvulsant agent 5 (Compound 5c) exhibits high affinity for GABAA receptors and NaV1.3 receptors. Anticonvulsant agent 5 shows anticonvulsant efficacy in mice psychomotor epilepsy test with an ED50 of 107 mg/kg. Anticonvulsant agent 5 exhibits neuroprotective activity against Kainic acid (HY-N2309) with an IC50 of 113 μM. Anticonvulsant agent 5 is blood-brain barrier (BBB) penetrable .
Cat. No.: HY-P5164
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Cat. No.: HY-RS12534
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Scn3a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scn3a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12535
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Scn3a Rat Pre-designed siRNA Set A contains three designed siRNAs for Scn3a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12533
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SCN3A Human Pre-designed siRNA Set A contains three designed siRNAs for SCN3A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P5810
CAS No.: 880885-98-3
Synonyms: CcoTx2; β-TRTX-cm1b
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
