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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Novobiocin
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Novobiocin" in MCE Product Catalog:
14
Novobiocin (Albamycin; Cathomycin) is an orally active antibiotic and Hsp-90 antagonist that also inhibits the Polθ helicase/ATPase domain with IC50 values of 24 μM and 15-17 μM, respectively. Novobiocin binds to Hsp90, GyrB, and POLθ, inhibiting their ATPase activity and ssDNA binding. Novobiocin inhibits molecular chaperone function and DNA repair, and induces apoptosis and genomic instability. Novobiocin exhibits bactericidal and antiparasitic activities. Novobiocin inhibits tumor growth in vivo. Novobiocin is used for research on equine piroplasmosis, ovarian cancer, breast cancer, anthrax, and melioidosis .
14
14 Cited Publications
Synonyms: Albamycin sodium; Cathomycin sodium
Cat. No.: HY-108248
CAS No.: 956498-70-7
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.
Cat. No.: HY-162595
CAS No.: 2892824-25-6
BDM88855 is an allosteric inhibitor for the homolog AcrB protein. BDM88855 can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli .
Cat. No.: HY-141442
CAS No.: 29826-16-2
Category:
Target:
Cat. No.: HY-162595A
CAS No.: 2892824-26-7
BDM88855 hydrochloride is an allosteric inhibitor for the homolog AcrB protein. BDM88855 hydrochloride can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli .
Cat. No.: HY-137806
CAS No.: 75057-97-5
Target:
Research Areas:
Descarbamylnovobiocin is a derivative of Novobiocin (HY-B0425).
Cat. No.: HY-189127
CAS No.: 668468-75-5
Antibacterial agent 373 is a broad-spectrum antibacterial agent. Antibacterial agent 373 exhibits antibacterial activity against Gram-negative/Gram-positive bacteria and some fungi, with MIC values ranging from 11.25 to 22.5 mg/mL. Antibacterial agent 373 is predicted to target Staphylococcus aureus topoisomerase IV, occupy the novobiocin binding pocket, and form hydrogen bonds with the active site residues Asn49 and Glu53. Antibacterial agent 373 can be used in studies related to bacterial and Candida infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
