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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
PRODH
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "PRODH" in MCE Product Catalog:
1
Category:
Alkaloids Human Gut Microbiota Metabolites Pyrrole Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. N-Propargylglycine covalently modifies enzyme-bound FAD and active site lysine, causing enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine induces UPRmt, upregulates mitochondrial chaperones and YME1L1, enhances mitochondrial proteostasis, blocks astrocytic L-proline consumption, and abolishes L-proline’s ATP-maintaining and viability-protective effects. N-Propargylglycine stimulates neural processes, increases brain proline, hydroxyproline, and sarcosine levels, partially normalizes Huntington’s disease whole brain transcriptomes. N-Propargylglycine reduces hyperoxaluria, prevents calcium oxalate stone formation, reduces kidney tubular damage, and restores weight and survival in Grhpr knockout mice. N-Propargylglycine can be used for the research of breast cancer, neurodegenerative disorders, Huntington’s disease, and primary hyperoxaluria type 2 .
Cat. No.: HY-RS11192
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PRODH Human Pre-designed siRNA Set A contains three designed siRNAs for PRODH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11193
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Research Areas:
PRODH2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRODH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-111095S2
CAS No.: 1224440-85-0
Synonyms: (R)-2-Hydroxypropionic acid-13C-1; D-Lactic acid-13C-1
Cat. No.: HY-RS21030
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Research Areas:
Prodh Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prodh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27547
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Research Areas:
Prodh Rat Pre-designed siRNA Set A contains three designed siRNAs for Prodh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P88241A
Synonyms: HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
