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Pimelic acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (3) HDAC (2) Isotope-Labeled Compounds (1) Monoamine Transporter (1) PROTAC Linkers (1) Reference Standards (1)
By Research Areas:	Cancer (3) Metabolic Disease (4) Neurological Disease (1)

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Products

Isotope-Labeled Compounds

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-Y1139

Pimelic acid 2 Publications Verification Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Endogenous Metabolite PROTAC Linkers	Metabolic Disease
Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .

HY-19348

Pimelic Diphenylamide 106 5 Publications Verification RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII	HDAC Monoamine Transporter	Neurological Disease Cancer
Pimelic Diphenylamide 106 (TC-H 106) is a slow, tight binding class I HDAC inhibitor (inhibits HDAC1, 2, and 3 with IC₅₀ values of 150 nM, 760 nM, and 370 nM, respectively), with no activity against class II HDACs. Pimelic Diphenylamide 106 modulates dopamine concentration and protects dopamine cells by inducing VMAT2 expression. Pimelic Diphenylamide 106 can be used in the study of neuropsychiatric diseases such as attention deficit hyperactivity disorder (ADHD) .

HY-W041806

7-Hydroxyheptanoic acid	Drug Intermediate	Others
7-Hydroxyheptanoic acid is an intermediate. 7-Hydroxyheptanoic acid can be dehydrolyzed to Pimelic acid (HY-Y1139). Pimelic acid derivatives can participate in the biosynthesis of lysine .

HY-W001472

Dimethyl pimelate Pimelic acid dimethyl ester	Drug Derivative	Metabolic Disease
Dimethyl pimelate (Pimelic acid dimethyl ester) is an ester product.

HY-176430

*Lenalidomide-amide-pimelic* acid**	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-amide-pimelic acid is an E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based CRBN ligand and Linker (HY-Y1139). Lenalidomide-amide-pimelic acid can be used for synthesis of PROTAC MNK1 degrader-1 (HY-176428) .

HY-Y1139R

Pimelic acid (Standard) Heptanedioic acid (Standard); 1,5-Pentanedicarboxylic acid (Standard); 1,7-Heptanedioic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Pimelic acid (Standard) is the analytical standard of Pimelic acid. This product is intended for research and analytical applications. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research .

HY-19430

Pimelic Diphenylamide 106 analog 2 Publications Verification RGFA-8 analog; TC-H 106 analog	HDAC	Cancer
Pimelic Diphenylamide 106 analog is the analog of Pimelic Diphenylamide 106, with unknown activity.

HY-Y1139S

Pimelic acid-d4 Heptanedioic acid-d₄; 1,5-Pentanedicarboxylic acid-d₄; 1,7-Heptanedioic acid-d₄	Endogenous Metabolite	Metabolic Disease
Pimelic acid-d₄ is the deuterium labeled Pimelic acid . Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.

HY-W001472S

Dimethyl pimelate-d4 Pimelic acid Dimethyl Ester-d₄	Isotope-Labeled Compounds	Others
Dimethyl pimelate-d₄ is the deuterium labeled Dimethyl pimelate .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-Y1139

Pimelic acid 2 Publications Verification Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PROTAC Linkers
Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .

HY-Y1139R

Pimelic acid (Standard) Heptanedioic acid (Standard); 1,5-Pentanedicarboxylic acid (Standard); 1,7-Heptanedioic acid (Standard)	Structural Classification Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Pimelic acid (Standard) is the analytical standard of Pimelic acid. This product is intended for research and analytical applications. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research .

Cat. No.	상품명	Chemical Structure

HY-Y1139S

Pimelic acid-d4
Pimelic acid-d₄ is the deuterium labeled Pimelic acid . Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.

HY-W001472S

Dimethyl pimelate-d4
Dimethyl pimelate-d₄ is the deuterium labeled Dimethyl pimelate .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Pimelic acid

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products