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Results for "

RBM39

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carbonic Anhydrase (2) Integrin (1) Molecular Glues (8) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (8) Infection (1) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13650

Indisulam 10+ Cited Publications E 7070	Molecular Glues Carbonic Anhydrase	Cancer
Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing *RBM39* degradation via recruitment to DCAF15 .

HY-14571

E7820 5 Publications Verification ER68203-00	Molecular Glues Integrin	Infection Metabolic Disease Cancer
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor *RBM39* by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .

HY-W133627

dCeMM1	Molecular Glues	Cancer
dCeMM1 is a *RBM39* glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4 ^DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells .

HY-RS23686

Rbm39 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rbm39 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rbm39 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rbm39 Rat Pre-designed siRNA Set A Rbm39 Rat Pre-designed siRNA Set A

HY-RS11751

RBM39 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RBM39 Human Pre-designed siRNA Set A contains three designed siRNAs for RBM39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RBM39 Human Pre-designed siRNA Set A RBM39 Human Pre-designed siRNA Set A

HY-173274

CB039	Molecular Glues	Cancer
CB039 is a selective a molecular glue degrader that targets *RBM39* (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer .

HY-177779

dRRM-1	Molecular Glues	Cancer
dRRM-1 is a DCAF15-dependent molecular glue degrader of *RBM39* and *RBM23*. dRRM-1 can rescue the self-degradation of DCAF15. dRRM-1 can be used for the research of cancer .

HY-RS17233

Rbm39 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rbm39 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rbm39 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rbm39 Mouse Pre-designed siRNA Set A Rbm39 Mouse Pre-designed siRNA Set A

HY-149441

Indisulam analog-1	Molecular Glues	Cancer
Indisulam analog-1 (Compound 4) is an analog of Indisulam (HY-13650). Indisulam analog-1 recruits *DCAF15-DDB1-DDA1-RBM39* with an EC₅₀ of 1.21 µM. Indisulam analog-1 can be used in the research of colon cancer .

HY-13650R

Indisulam (Standard) E 7070 (Standard)	Molecular Glues Carbonic Anhydrase Reference Standards	Cancer
Indisulam (Standard) is the analytical standard of Indisulam. This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15 .

HY-183755

YSA64	Molecular Glues	Cancer
YSA64 is an orally active *RBM39*-targeting molecular glue. YSA64 promotes degradation via formation of a DCAF15/DDB1 ternary complex, dependent on Cullin-RING E3 ligase and proteasome activity. YSA64 can be used for the research of acute myeloid leukemia and Ewing sarcoma .

Rbm39 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Rbm39 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rbm39 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

RBM39 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RBM39 Human Pre-designed siRNA Set A contains three designed siRNAs for RBM39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rbm39 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rbm39 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rbm39 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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