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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
RNF4
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "RNF4" in MCE Product Catalog:
Target:
Research Areas:
CCW16 is a cofactor for the synthesis of protein degraders, such as PROTACs CCW 28-3 (HY-156774).
Cat. No.: HY-156774
CAS No.: 2361142-23-4
Target:
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CCW 28-3 is a BRD4 PROTAC degrader. CCW 28-3 recruits RNF4 to BRD4, inducing RNF4-dependent ubiquitination and proteasomal degradation of BRD4. CCW 28-3 can be used in breast cancer-related research .
Cat. No.: HY-RS12090
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RNF4 Human Pre-designed siRNA Set A contains three designed siRNAs for RNF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24107
Target:
Research Areas:
Rnf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rnf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181692
Research Areas:
PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader (Kd = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system. PROTAC RNF4 degrader-1 induces DNA damage, apoptosis, and exhibits antiproliferative activity in cancer cells. PROTAC RNF4 degrader-1 displays antitumor activity with no obvious side effects in mouse models. PROTAC RNF4 degrader-1 is applicable to the research of hepatocellular carcinoma .
Cat. No.: HY-RS17647
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Research Areas:
Rnf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rnf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-170383
Research Areas:
CCW16-C4-NHBoc (RNF4 ligand CCW16 (HY-143346)) is an E3 Ligase Ligand-Linker Conjugate for BRD4 PROTAC CCW 28-3 (HY-156774) .
Cat. No.: HY-181693
Research Areas:
CCW16-C2-Boc is a conjugate targeting RNF4, formed by coupling the target protein ligand CCW16 (HY-143346) with a PROTAC Linker. CCW16-C2-Boc can be used to synthesize the PROTAC degrader: PROTAC RNF4 degrader-1 (HY-181693) .
Cat. No.: HY-P702078
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF4; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF
Cat. No.: HY-P702079
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF4; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF
Cat. No.: HY-P703187
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SNURF
Cat. No.: HY-P703188
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SNURF
Cat. No.: HY-P703189
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SNURF
Cat. No.: HY-184506
Research Areas:
R4VPL3-1 is a PROTAC-like degrader that simultaneously targets RNF4 and VHL, and also acts as a ferroptosis inducer. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 is applicable to research on human melanoma, human cutaneous squamous cell carcinoma, metastatic human sarcoma, malignant peripheral nerve sheath tumor, pigmented villonodular synovitis, undifferentiated pleomorphic sarcoma, myxofibrosarcoma, and lung adenocarcinoma .
Cat. No.: HY-184508
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E3 ligase Ligand 81 is a VHL E3 ubiquitin ligase ligand and constitutes the VHL ligand moiety of R4VPL3-1 (HY-184506). R4VPL3-1 is a PROTAC-like bifunctional degrader linking RNF4 and VHL; it binds to and modifies GPX4, thereby inhibiting its anti-ferroptotic function. R4VPL3-1 induces iron-dependent lipid peroxidation and rapid ferroptosis-mediated cell death in cancer cells. E3 ligase Ligand 81 can be used in research related to targeted protein degradation and tumors such as melanoma .
Cat. No.: HY-184507
CAS No.: 2975257-92-0
Target:
Research Areas:
(R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 (HY-184506). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
