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Retinoic acid (Standard)

" in MedChemExpress (MCE) Product Catalog:

24

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5

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14649R
    Retinoic acid (Standard)
    125+ Cited Publications

    Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)

    		 Reference Standards RAR/RXR PPAR Endogenous Metabolite Autophagy Cancer
    Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
    Retinoic acid (Standard)
  • HY-15127R
    Isotretinoin (Standard)

    13-cis-Retinoic acid (Standard)

    		 Reference Standards RAR/RXR Endogenous Metabolite Autophagy Cancer
    Isotretinoin (Standard) is the analytical standard of Isotretinoin. This product is intended for research and analytical applications. Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity .
    Isotretinoin (Standard)
  • HY-107494R
    13-cis-4-Oxoretinoic acid (Standard)

    4-Keto 13-cis-Retinoic acid (Standard); 4-Oxoisotretinoin (Standard); Ro 22-6595 (Standard)

    		 Reference Standards Endogenous Metabolite Others
    13-cis-4-Oxoretinoic acid (Standard) is the analytical standard of 13-cis-4-Oxoretinoic acid (HY-107494). This product is intended for research and analytical applications. 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .
    13-cis-4-Oxoretinoic acid (Standard)
  • HY-14531R
    Talarozole (Standard)

    R115866 (Standard)

    		 RAR/RXR Cytochrome P450 Autophagy Reference Standards Inflammation/Immunology
    Talarozole (Standard) is the analytical standard of Talarozole. This product is intended for research and analytical applications. Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.
    Talarozole (Standard)
  • HY-14652R
    Tamibarotene (Standard)

    Am 80 (Standard)

    		 RAR/RXR Autophagy Apoptosis Reference Standards Cancer
    Tamibarotene (Standard) is the analytical standard of Tamibarotene. This product is intended for research and analytical applications. Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.
    Tamibarotene (Standard)
  • HY-15128R
    9-cis-Retinoic acid (Standard)

    Alitretinoin (Standard)

    		 Reference Standards RAR/RXR Apoptosis Endogenous Metabolite Neurological Disease Inflammation/Immunology Cancer
    9-cis-Retinoic acid (Standard) is the analytical standard of 9-cis-Retinoic acid. This product is intended for research and analytical applications. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5].
    9-cis-Retinoic acid (Standard)
  • HY-107494AR
    all-trans-4-Oxoretinoic acid (Standard)

    all-trans 4-Keto Retinoic acid (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
    all-trans-4-Oxoretinoic acid (Standard)
  • HY-106019R
    Liarozole (Standard)

    R75251 (Standard)

    		 Reference Standards Cytochrome P450 RAR/RXR Metabolic Disease Inflammation/Immunology Cancer
    Liarozole (Standard) is the analytical standard of Liarozole. This product is intended for research and analytical applications. Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties .
    Liarozole (Standard)
  • HY-112077AR
    Viaminate (Standard)

    		RAR/RXR Reference Standards Inflammation/Immunology
    Viaminate (Standard) is the analytical standard of Viaminate. This product is intended for research and analytical applications. Viaminate is a derivative of Retinoic acid, which is used for the treatment of severe acne and other keratinization disorders.
    Viaminate (Standard)
  • HY-100532R
    CD437 (Standard)

    AHPN (Standard)

    		 Reference Standards RAR/RXR Autophagy Cancer
    CD437 (Standard) is the analytical standard of CD437. This product is intended for research and analytical applications. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
    CD437 (Standard)
  • HY-15373R
    Fenretinide (Standard)

    4-HPR (Standard); ISLA-101 (Standard)

    		 Reference Standards RAR/RXR Autophagy Cancer
    Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
    Fenretinide (Standard)
  • HY-15388R
    Tazarotene (Standard)

    AGN 190168 (Standard)

    		 Reference Standards RAR/RXR Autophagy Inflammation/Immunology Cancer
    Tazarotene (Standard) is the analytical standard of Tazarotene. This product is intended for research and analytical applications. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Tazarotene (Standard)
  • HY-106019CR
    Liarozole dihydrochloride (Standard)

    R75251 dihydrochloride (Standard)

    		 Reference Standards Cytochrome P450 RAR/RXR Metabolic Disease Inflammation/Immunology Cancer
    Liarozole (dihydrochloride) (Standard) is the analytical standard of Liarozole (dihydrochloride). This product is intended for research and analytical applications. Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties .
    Liarozole dihydrochloride (Standard)
  • HY-P1934AR
    Cyclo(L-Phe-L-Pro) (Standard)

    		Reference Standards Fungal Bacterial IFNAR Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
    Cyclo(L-Phe-L-Pro) (Standard)
  • HY-100008R
    Peretinoin (Standard)

    NIK333 (Standard)

    		 Reference Standards RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
    Peretinoin (Standard)
  • HY-108522R
    PA452 (Standard)

    		Reference Standards RAR/RXR Metabolic Disease
    PA452 (Standard) is the analytical standard of PA452 (HY-108522). This product is intended for research and analytical applications. PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development .
    PA452 (Standard)
  • HY-107395R
    BMS 753 (Standard)

    		Reference Standards RAR/RXR Inflammation/Immunology
    BMS 753 (Standard) is the analytical standard of BMS 753 (HY-107395). This product is intended for research and analytical applications. BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a Ki of 2 nM .
    BMS 753 (Standard)
  • HY-107765R
    LY2955303 (Standard)

    		Reference Standards RAR/RXR Autophagy Inflammation/Immunology
    LY2955303 (Standard) is the analytical standard of LY2955303 (HY-107765). This product is intended for research and analytical applications. LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.
    LY2955303 (Standard)
  • HY-108529R
    BMS493 (Standard)

    		Reference Standards RAR/RXR Metabolic Disease
    BMS493 (Standard) is the analytical standard of BMS493 (HY-108529). This product is intended for research and analytical applications. BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation . BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BMS493 (Standard)
  • HY-101106R
    AR7 (Standard)

    		RAR/RXR Reference Standards Neurological Disease Cancer
    AR7 (Standard) is the analytical standard of AR7 (HY-101106). This product is intended for research and analytical applications. AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .
    AR7 (Standard)
  • HY-108532R
    AC-261066 (Standard)

    		Reference Standards RAR/RXR Cancer
    AC-261066 (Standard) is the analytical standard of AC-261066 (HY-108532). This product is intended for research and analytical applications. AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0 .
    AC-261066 (Standard)
  • HY-106735R
    Arotinoid (Standard)

    Ro 13-6298 (Standard); Arotinoid ethyl ester (Standard)

    		 Reference Standards RAR/RXR Inflammation/Immunology Cancer
    Arotinoid (Standard) (Ro 13-6298 (Standard)) is the analytical standard of Arotinoid (HY-106735). This product is intended for research and analytical applications. Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED50 of 0.05 mg/kg. Arotinoid can be used for the research of sKin carcinomas .
    Arotinoid (Standard)
  • HY-101954AR
    Inarigivir ammonium (Standard)

    ORI-9020 ammonium (Standard); SB-9000 ammonium (Standard)

    		 Reference Standards HBV Infection Inflammation/Immunology
    Inarigivir ammonium (Standard) is the analytical standard of Inarigivir ammonium (HY-101954A). This product is intended for research and analytical applications. Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses .
    Inarigivir ammonium (Standard)
  • HY-107397R
    Ch55 (Standard)

    		Reference Standards RAR/RXR Cancer
    Ch55 (Standard) is the analytical standard of Ch55 (HY-107397). This product is intended for research and analytical applications. Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research .
    Ch55 (Standard)

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