2. Search Result
Search Result
Isoforms Recommended: SHMT1
Results for "

SHMT1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112066
    SHIN1
    15+ Cited Publications

    RZ-2994

    		 SHMT Cancer
    SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
    SHIN1
  • HY-129226
    SHMT-IN-2

    		SHMT Endocrinology Cancer
    SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas [1].
    SHMT-IN-2
  • HY-148545
    SHMT-IN-3

    		SHMT Cancer
    SHMT-IN-3 (Hit 1) is a SHMT1 and SHMT2 inhibitor with an IC50 of 0.53 µM for human SHMT1. SHMT-IN-3 exhibits noncompetitive inhibition against serine [1].
    SHMT-IN-3
  • HY-178432
    SHMT2-IN-1

    		SHMT Apoptosis Reactive Oxygen Species (ROS) Cancer
    SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer [1].
    SHMT2-IN-1
  • HY-RS12876
    SHMT1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SHMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SHMT1 Human Pre-designed siRNA Set A
    SHMT1 Human Pre-designed siRNA Set A
  • HY-162883
    SHMT-IN-4

    		SHMT Others
    SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC50 value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees [1].
    SHMT-IN-4
  • HY-RS24663
    Shmt1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Shmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Shmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Shmt1 Rat Pre-designed siRNA Set A
    Shmt1 Rat Pre-designed siRNA Set A
  • HY-RS18189
    Shmt1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Shmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Shmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Shmt1 Mouse Pre-designed siRNA Set A
    Shmt1 Mouse Pre-designed siRNA Set A
  • HY-177092
    AGF347

    		Antifolate SHMT Apoptosis mTOR Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research [1] .
    AGF347

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: