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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
84 Results for "
SMARCA2/4 PROTAC degrader
" in MedChemExpress (MCE) Product Catalog:
Products (84)
84 Results for "SMARCA2/4 PROTAC degrader" in MCE Product Catalog:
Cat. No.: HY-W382038
CAS No.: 2300099-98-1
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E3 ligase Ligand 32 (First product in Example 3) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) .
Cat. No.: HY-173333
CAS No.: 3081688-77-6
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PROTAC SMARCA2/4 degrader-38 is a SMARCA2/4 degrader (SMARCA2: DC50 = 3.0 nM; SMARCA4: 4.0 nM). PROTAC SMARCA2/4 degrader-38 binds to SMARCA2 and SMARCA4 bromodomains to induce degradation via the ubiquitin-proteasome system. PROTAC SMARCA2/4 degrader-38 induces G0/G1 phase cell cycle arrest and cell apoptosis in hematological cancer cells, blocks oncogenic activity of MYC and other disease-related genes in acute myeloid leukemia cells and inhibits proliferation of hematological cancer cell lines. PROTAC SMARCA2/4 degrader-38 can be used for the research of acute myeloid leukemia, diffuse large B-cell lymphoma, breast cancer, ovarian cancer, colorectal cancer, liver cancer, lung cancer .
Cat. No.: HY-153425
CAS No.: 2892523-74-7
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PROTAC SMARCA2/4 degrader-41 is a SMARCA2/4 PROTAC degrader with a DC50 and IC50 both < 0.1 μM. PROTAC SMARCA2/4 degrader-41 is applicable to research on SMARCA2/4-related or SMARCA2/4-deficient cancers .
Cat. No.: HY-178225
CAS No.: 3099581-74-2
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PROTAC SMARCA2/4 degrader-39 is a SMARCA2 and SMARCA4 PROTAC degrader with DC50 values of < 0.1 nM and 0.1-<1 nM, respectively. PROTAC SMARCA2/4 degrader-39 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-39 is applicable to cervical cancer research .
Cat. No.: HY-162745
CAS No.: 2568273-85-6
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PROTAC SMARCA2/4 degrader-42 is a SMARCA2 and SMARCA4 PROTAC degrader that induces protein ubiquitination and subsequent proteasomal degradation. PROTAC SMARCA2/4 degrader-42 can be used in cancer-related research .
Cat. No.: HY-162835
CAS No.: 2409844-88-6
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PROTAC SMARCA2/4 degrader-28 is a heterobifunctional PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-28 forms a ternary complex with CRL2VHL E3 ligase and SMARCA2 or SMARCA4, mediating the ubiquitination and degradation of SMARCA2, while acting as a partial degrader of SMARCA4. PROTAC SMARCA2/4-degrader-28 can be used in cancer-related research .
Cat. No.: HY-159454
CAS No.: 2568507-10-6
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PROTAC SMARCA2/4 degrader-3 is a SMARCA2 and SMARCA4 PROTAC degrader. It is applicable to cancer-related research .
Cat. No.: HY-178215
CAS No.: 3099581-65-1
BRM/BRG1 ligand 4 (Compound 6) is a SMARCA2/4 PROTAC degrader. BRM/BRG1 ligand 4 exhibits potent degradation activity against both SMARCA2 and SMARCA4 in HeLa cells, with DC50 less than 0.1 nM. BRM/BRG1 ligand 4 can be used for the study of cancers associated with SMARCA2/SMARCA4 abnormalities or SWI/SNF mutations .
Cat. No.: HY-170347
CAS No.: 3033588-00-7
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PROTAC SMARCA2/4 degrader-36 is a bifunctional PROTAC degrader that degrades SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-36 hijacks the ubiquitin-proteasome system to mediate the degradation of SMARCA2/4 by binding to the VHL E3 ubiquitin ligase. PROTAC SMARCA2/4 degrader-36 downregulates SMARCA2/4 in tumor tissues in mouse xenograft models . PROTAC SMARCA2/4 degrader-36 can be used in studies related to non-small cell lung cancer .
Cat. No.: HY-162748
CAS No.: 2568276-44-6
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PROTAC SMARCA2/4 degrader-30 is a SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-30 induces ubiquitination and proteasome-mediated degradation of proteins. PROTAC SMARCA2/4 degrader-30 is applicable for cancer-related research .
Cat. No.: HY-159461
CAS No.: 2568507-15-1
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PROTAC SMARCA2/4 degrader-9 is a SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-9 induces protein ubiquitination and subsequent proteasome-mediated degradation. PROTAC SMARCA2/4 degrader-9 can be used in cancer-related research .
Cat. No.: HY-163866
CAS No.: 2568276-73-1
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PROTAC SMARCA2/4 degrader-43 is a PROTAC degrader targeting SMARCA2/4, which induces ubiquitination and proteasomal degradation of the protein. PROTAC SMARCA2/4 degrader-43 is applicable to cancer-related research .
Cat. No.: HY-159460
CAS No.: 2568507-14-0
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PROTAC SMARCA2/4 degrader-8 is a SMARCA2/SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-8 induces ubiquitination, proteasome-mediated degradation, and recruits the E3 ubiquitin ligase complex. PROTAC SMARCA2/4 degrader-8 is applicable for cancer-related research .
Cat. No.: HY-159453
CAS No.: 2568277-76-7
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PROTAC SMARCA2/4 degrader-2 is a PROTAC degrader targeting SMARCA2 and SMARCA4, with a DC50 of < 100 nM for both proteins. PROTAC SMARCA2/4 degrader-2 induces ubiquitination and subsequent proteasome-mediated degradation of SMARCA2 and SMARCA4 proteins. PROTAC SMARCA2/4 degrader-2 can be used in cancer-related research .
Cat. No.: HY-163867
CAS No.: 2568276-78-6
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PROTAC SMARCA2/4 degrader-44 is a PROTAC-based protein degrader targeting SMARCA2/4, which induces ubiquitination and subsequent degradation of the target proteins. PROTAC SMARCA2/4 degrader-44 is applicable for cancer-related research .
Cat. No.: HY-159459
CAS No.: 2568273-79-8
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PROTAC SMARCA2/4 degrader-32 is a SMARCA2/SMARCA4 PROTAC degrader. PROTAC SMARCA2/4 degrader-32 induces ubiquitination, proteasome-mediated degradation, and recruits the E3 ubiquitin ligase complex. PROTAC SMARCA2/4 degrader-32 can be used in cancer-related research .
Cat. No.: HY-163864
CAS No.: 2568276-71-9
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PROTAC SMARCA2/4 degrader-11 is a PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2/4 degrader-11 induces protein ubiquitination and subsequent proteasome-mediated degradation. PROTAC SMARCA2/4-degrader-11 can be used in cancer-related research .
Cat. No.: HY-162813
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PROTAC SMARCA2/4 degrader-25 is a selective SMARCA2/SMARCA4 PROTAC degrader with selective anti-tumor activity. PROTAC SMARCA2/4 degrader-25 is activated by endogenous GSH, forms a ternary complex with SMARCA2 or SMARCA4 and VHL E3 ubiquitin ligase, and mediates degradation via the proteasome pathway. PROTAC SMARCA2/4 degrader-25 induces DNA damage and apoptosis, and inhibits cancer cell proliferation. PROTAC SMARCA2/4 degrader-25 is applicable to lung cancer-related research .
Cat. No.: HY-159455
CAS No.: 2568523-81-7
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PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
Cat. No.: HY-162815
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PROTAC SMARCA2/4 degrader-26 is a SMARCA2/4 PROTAC degrader with selective anti-tumor activity against lung cancer cells. PROTAC SMARCA2/4 degrader-26 degrades SMARCA2 and SMARCA4 via the PROTAC-mediated proteasomal pathway. It induces DNA damage and apoptosis in tumor cells, while inhibiting migration and colony formation of lung cancer cells; in addition, it damages normal vascular endothelial cells and exhibits significant off-target-related cytotoxicity. PROTAC SMARCA2/4 degrader-26 serves as the parent scaffold to construct the GSH-responsive prodrug PROTAC SMARCA2/4 degrader-25 (HY-162813), a derivative that shows drastically reduced cytotoxicity against normal cells. PROTAC SMARCA2/4 degrader-26 can be used in lung cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
