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Cat. No.: HY-162745

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PROTAC SMARCA2/4 degrader-42

PROTAC SMARCA2/4 degrader-42 is a SMARCA2 and SMARCA4 PROTAC degrader that induces protein ubiquitination and subsequent proteasomal degradation. PROTAC SMARCA2/4 degrader-42 can be used in cancer-related research.
(Pink: SMARCA2 ligand (HY-159542); Blue: Cereblon ligand (HY-W087383); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2568273-85-6
Formule: C₃₈H₄₁N₉O₅
Masse moléculaire:703.79

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC SMARCA2/4 degrader-42 Chemical Structure

CAS No.: 2568273-85-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

PROTAC SMARCA2/4 degrader-42 is a SMARCA2 and SMARCA4 PROTAC degrader that induces protein ubiquitination and subsequent proteasomal degradation. PROTAC SMARCA2/4 degrader-42 can be used in cancer-related research^[1]. (Pink: SMARCA2 ligand (HY-159542); Blue: Cereblon ligand (HY-W087383); Black: linker).

IC₅₀ & Target

^[1]

SMARCA2

SMARCA4

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform SWI/SNF Complex :

In Vitro

PROTAC SMARCA2/4 degrader-42 (I-281) (24 h) potently degrades SMARCA2 protein in A549 cells, with a DC₅₀ < 100 nM and a degradation rate of over 90% after 24 hours^[1].
PROTAC SMARCA2/4 degrader-42 (24 h) potently degrades SMARCA4 protein in MV4-11 cells, with a DC₅₀ < 100 nM and a degradation rate of over 90% after 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2568273-85-6
Masse moléculaire 703.79
Formule C₃₈H₄₁N₉O₅
SMILES

OC1=CC=CC=C1C2=CC(C3=CN(C4CCN([C@H]5CC[C@@H](CNC6=CC(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)=C8C=C6)CC5)CC4)N=C3)=C(N)N=N2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ji N, et al. Smarca degraders and uses thereof. US20230072658A1. USPTO. 2023.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

PROTAC SMARCA2/4 degrader-42

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PROTAC SMARCA2/4 degrader-42

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform SWI/SNF Complex

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs