PROTAC SMARCA2/4 degrader-42
PROTAC SMARCA2/4 degrader-42 is a SMARCA2 and SMARCA4 PROTAC degrader that induces protein ubiquitination and subsequent proteasomal degradation. PROTAC SMARCA2/4 degrader-42 can be used in cancer-related research.
(Pink: SMARCA2 ligand (HY-159542); Blue: Cereblon ligand (HY-W087383); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2568273-85-6
- Formula: C38H41N9O5
- Molecular Weight:703.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4 degrader-42 (I-281) (24 h) potently degrades SMARCA2 protein in A549 cells, with a DC50 < 100 nM and a degradation rate of over 90% after 24 hours[1].
PROTAC SMARCA2/4 degrader-42 (24 h) potently degrades SMARCA4 protein in MV4-11 cells, with a DC50 < 100 nM and a degradation rate of over 90% after 24 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568273-85-6
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Molecular Weight 703.79
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Formula C38H41N9O5
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SMILES
OC1=CC=CC=C1C2=CC(C3=CN(C4CCN([C@H]5CC[C@@H](CNC6=CC(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)=C8C=C6)CC5)CC4)N=C3)=C(N)N=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-42 Related Classifications
HY-162745 Related Classifications
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