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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
SPOP
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "SPOP" in MCE Product Catalog:
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Research Areas:
NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains . NEO2734 is active in SPOP mutant and wild-type prostate cancer .
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3 Cited Publications
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SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM (patent CN 107141287, SPOP-B-88) .
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3 Cited Publications
Cat. No.: HY-122615B
Purity: 99.70%
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SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM .
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SPOP-IN-1 is a selective SPOP E3 ubiquitin ligase inhibitor. SPOP-IN-1 leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma .
Cat. No.: HY-175247
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DDO-4033 is a SPOP inhibitor (IC50 = 16.9 μM, Kd = 15.1 μM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research .
Cat. No.: HY-161251
CAS No.: 3031640-86-2
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SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC .
Cat. No.: HY-122615A
CAS No.: 2136270-68-1
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SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM .
Cat. No.: HY-176035
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MS479 is a BRD4 PROTAC degrader. MS479 binds BRD4-BD2 and GLP with high affinities (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). MS479 can reduce the protein level of BRD4 short isoform. MS479 recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein. MS479 can be used to inhibit the proliferation of colorectal cancer cells .
Cat. No.: HY-RS13700
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SPOP Human Pre-designed siRNA Set A contains three designed siRNAs for SPOP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23229
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Spop Rat Pre-designed siRNA Set A contains three designed siRNAs for Spop gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-176038
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MS1262-C3-amide-C10-amine is a E3 Ligase Ligand-Linker Conjugates. MS1262-C3-amide-C10-amine incorporates a GLP ligand for the E3 ligase SPOP (HY-176036), and a PROTAC linker (HY-176037). MS1262-C3-amide-C10-amine can be used to design PROTACs such as MS479 (HY-176035) .
Cat. No.: HY-RS16789
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Spop Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spop gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703241
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Speckle-type POZ protein; HIB homolog 1; Roadkill homolog 1; SPOP; Homo sapiens; Human
Cat. No.: HY-P82309A
Synonyms: Speckle-type POZ protein; HIB homolog 1; Roadkill homolog 1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
