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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
Sir2
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "Sir2" in MCE Product Catalog:
313
313 Publications Verification
Synonyms: EX-527
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Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease [2].
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4 Cited Publications
Cat. No.: HY-N2031
CAS No.: 62499-28-9
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1 Cited Publications
Cat. No.: HY-P80322
Synonyms: Sir2L6, SirT6, NAD-dependent protein deacylase Sirtuin-6, NAD-dependent protein deacetylase Sirtuin-6, Protein mono-ADP-ribosyltransferase Sirtuin-6, Regulatory protein Sir2 homolog 6, Sir2-like protein 6, hSirT6
Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD +-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM .
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Cat. No.: HY-15452R
CAS No.: 49843-98-3
Synonyms: EX-527 (Standard)
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Selisistat (Standard) is the analytical standard of Selisistat. This product is intended for research and analytical applications. Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease [2].
Cat. No.: HY-RS12937
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SIRT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12940
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SIRT2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W156961
CAS No.: 885-70-1
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LS-75 is a PARP-1 inhibitor with blood-brain permeability and IC50 value of 18 μM. LS-75 has neuroprotective activity .
Cat. No.: HY-RS12938
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Sirt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N2031R
CAS No.: 62499-28-9
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Cat. No.: HY-W142410
CAS No.: 10203-28-8
2-Dodecanol inhibits hyphal formation and SIR2 expression in C. albicans .
Cat. No.: HY-100585R
CAS No.: 5690-03-9
Synonyms: Splitomycin (Standard)
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Research Areas:
Splitomicin (Standard) is the analytical standard of Splitomicin. This product is intended for research and analytical applications. Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM .
Cat. No.: HY-133859
CAS No.: 51314-51-3
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M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans .
Cat. No.: HY-P85522
Synonyms: 2810449N18Rik; AI043036; Mono ADP ribosyltransferase Sirtuin 6; NAD-dependent protein deacetylase Sirtuin-6; Regulatory protein Sir2 homolog 6; Regulatory protein Sir2 homolog; Sir2 like 6; Sir2 like protein 6; Sir2 related protein type 6; Sir2-like protein 6; Sir2
Cat. No.: HY-P85521A
Synonyms: FLJ35621; FLJ37491; NAD dependent deacetylase Sirtuin 2; NAD-dependent deacetylase Sirtuin-2; NAD-dependent protein deacetylase Sirtuin-2; Regulatory protein Sir2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; Sir 2; Sir2; Sir2 like; Sir2 like protein 2; Sir2 related protein type 2; Sir2, S. cerevisiae, homolog-loke 2; Sir2-like protein 2; Sir2L; Sir2L2; SirT 2; SirT2; SirT2_HUMAN; Sirtuin; silent mating type information regulation 2 homolog; 2; S.cerevisiae; Sirtuin 2; Sirtuin type 2; Sirtuin2.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
