7 Results for "

Sirtuin 6

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "Sirtuin 6" in MCE Product Catalog:

34
34 Publications Verification
Cat. No.: HY-107454
CAS No.: 887686-02-4
Purity:  98.63%
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .
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17
17 Cited Publications
Cat. No.: HY-115453
CAS No.: 358721-70-7
Purity:  98.88%
Target:  

Sirtuin Autophagy

Research Areas:  

Cancer

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM .
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1
1 Cited Publications
Cat. No.: HY-P80322
Synonyms: SIR2L6, SIRT6, NAD-dependent protein deacylase Sirtuin-6, NAD-dependent protein deacetylase Sirtuin-6, Protein mono-ADP-ribosyltransferase Sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, hSIRT6

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, FC

Reactivity:  

Human, Mouse

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Cat. No.: HY-N2126
CAS No.: 952068-57-4
Parishin E is a modulator of hexokinase 2, lactate dehydrogenase A, and silent information regulator 6 (sirtuin 6), and is also a component present in Gastrodia elata Blume . Parishin E reduces the expression of hexokinase 2 and lactate dehydrogenase A, thereby regulating the process of cellular glycolysis . Parishin E regulates the deacetylation mediated by silent information regulator 6 (Sirtuin 6), and inhibits histone 3 lactylation modifications at the H3K18la and H3K27la sites . Parishin E inhibits macrophage polarization . Parishin E alleviates LPS-induced inflammatory responses and suppresses the expression of pro-inflammatory cytokines . Parishin E exerts ameliorating effects on rheumatoid arthritis . Parishin E can be used in studies related to rheumatoid arthritis .
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Cat. No.: HY-169159
CAS No.: 2867630-96-2
Target:  

Sirtuin

Research Areas:  

Metabolic Disease

SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases .
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Cat. No.: HY-P85522
Synonyms: 2810449N18Rik; AI043036; Mono ADP ribosyltransferase Sirtuin 6; NAD-dependent protein deacetylase Sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2

Host:  

Mouse

Application:  

WB, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat, Monkey

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Cat. No.: HY-107454R
CAS No.: 887686-02-4
OSS_128167 (Standard) is the analytical standard of OSS_128167 (HY-107454). This product is intended for research and analytical applications. OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .
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