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Results for "

Thermal stabilization

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19745
    BMS-202
    20+ Cited Publications

    		 PD-1/PD-L1 Apoptosis Cancer
    BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity .
    BMS-202
  • HY-111772A
    (R)-Elexacaftor

    (R)-VX-445

    		 Drug Isomer CFTR Inflammation/Immunology
    (R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis .
    (R)-Elexacaftor
  • HY-W087905
    2,3-Dimethyl-2,3-diphenylbutane

    		Biochemical Assay Reagents Others
    2,3-Dimethyl-2,3-diphenylbutane is a minor product formed during the thermal decomposition of dicumyl peroxide (DCP) in cumene, generated through radical coupling reactions. As an initiator capable of producing free radicals, 2,3-dimethyl-2,3-diphenylbutane promotes cross-linking or decomposition processes via initiating free radical reactions in fields such as polymer polymerization (e.g., modification of polyphenylene oxide processing), organic synthesis (e.g., DCP decomposition reactions), and coal processing (e.g., oxidation stabilization of coal tar pitch), thereby enhancing material properties or reaction efficiency .
    2,3-Dimethyl-2,3-diphenylbutane
  • HY-125209A
    TH5427 hydrochloride

    		Apoptosis PARP DNA/RNA Synthesis Cancer
    TH5427 hydrochloride is a NUDT5 inhibitor with a human target IC50 of 29 nM, ~690-fold selectivity over MTH1 in vitro, and selective functional inhibition over other NUDIX hydrolases including NUDT9 .TH5427 hydrochloride binds to the active site of NUDT5, blocking enzymatic activity related to ADP-ribose metabolism and PAR-derived ATP synthesis .TH5427 hydrochloride blocks progestin-dependent nuclear ATP synthesis, impairs progestin-induced chromatin remodeling, inhibits histone H1 displacement, disrupts progestin-dependent gene regulation, and abrogates progestin-dependent proliferation in breast cancer cells .TH5427 hydrochloride functions as a versatile probe to study nuclear ATP dynamics and ADP-ribose-related metabolism in cells .TH5427 hydrochloride engages NUDT5 at physiological temperatures, as demonstrated by Drug Affinity Responsive Target Stability (DARTS) assay .TH5427 hydrochloride stabilizes NUDT5 against thermal denaturation in cell lysates and intact cells, as shown by cellular thermal shift assay (CETSA) .TH5427 hydrochloride functionally inhibits NUDT5 activity, leading to downstream effects on oxidative DNA damage and DNA replication in triple-negative breast cancer (TNBC) cells .TH5427 hydrochloride suppresses proliferation of TNBC cells without inducing cell death or apoptosis, slows DNA replication in TNBC cells, promotes accumulation of oxidative DNA lesions, and triggers DNA damage response in TNBC cells .TH5427 hydrochloride suppresses growth of TNBC cells in vitro, inhibits growth of TNBC xenograft tumors in nude mice in vivo, and shows greater potency against TNBC cell lines compared to ER-positive and normal-like breast cell lines .TH5427 hydrochloride can be used for the research of breast cancer and triple-negative breast cancer .
    TH5427 hydrochloride
  • HY-19745B
    BMS-202 hydrochloride
    20+ Cited Publications

    		 PD-1/PD-L1 Apoptosis Cancer
    BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity .
    BMS-202 hydrochloride
  • HY-120594
    R78206

    		Enterovirus Others
    R78206 is an antiviral pyridazinamine compound with the activity of protecting poliovirus from thermal inactivation, having different effects on different poliovirus strains at different concentrations, and having a highly effective stabilizing effect on Mahoney procapsids.
    R78206
  • HY-147934
    HDAC8-IN-3

    		HDAC Apoptosis Cancer
    HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines .
    HDAC8-IN-3
  • HY-116258
    C16 Ceramide (d16:1,C16:0)

    		Liposome Others
    C16 Ceramide (d16:1,C16:0) is a bioactive sphingolipid that induces ordered- and gel-phase formation and thermal stabilization of palmitoylsphingomyelin-rich domains in palmitoylphosphocholine (POPC) bilayers. C16 Ceramide (d16:1,C16:0) is found in sphingomyelins in human erythrocytes .
    C16 Ceramide (d16:1,C16:0)
  • HY-N12639
    β-Sanshool

    		TRP Channel Others
    β-Sanshool is found in Zanthoxylum bungeanum and has a unique pungent taste. β-Sanshool is a TRPV1 activator that activates TRPV1 to increase intracellular calcium concentration. β-Sanshool has antioxidant effects and enhances free radical scavenging activity. β-Sanshool increases the thermal denaturation temperature and stabilizes protein structures. β-Sanshool induces sensory experiences of numbness and bitterness .
    β-Sanshool
  • HY-W002006
    6-Amino-1,3-dimethyluracil

    		Biochemical Assay Reagents Others
    6-Amino-1,3-dimethyluracil is a 6-aminouracil derivative and also functions as an organic thermal stabilizer for polyvinyl chloride (PVC). Its compatibility with PVC is lower than that of Ca 2+/Zn 2+ stabilizers and alkyl-substituted bis(6-amino-1,3-dimethyluracil-5-yl)methane derivatives. 6-Amino-1,3-dimethyluracil can be used to prepare PVC films, which exhibit lower transparency compared to PVC films stabilized by its derived bis-uracil compounds .
    6-Amino-1,3-dimethyluracil

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