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VEEV

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By Targets:	AAK1 (1) CHIKV (7) Dengue Virus (1) DNA/RNA Synthesis (1) Endogenous Metabolite (5) Enterovirus (6) Flavivirus (1) HCV (6) IFNAR (1) MyD88 (1) Poly(ADP-ribose) Glycohydrolase (PARG) (2) Protease Activated Receptor (PAR) (2) SARS-CoV (7) STING (1) Topoisomerase (6) Virus Protease (7)
By Research Areas:	Infection (17) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125033

EIDD-1931 Maximum Cited Publications 39 Publications Verification β-D-N4-hydroxycytidine; NHC	CHIKV SARS-CoV Enterovirus HCV Topoisomerase	Infection
EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .

HY-19711

STING agonist-1 4 Publications Verification G10	STING Virus Protease	Infection
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC₉₀ of 24.57 μM .

HY-12928

ML336	Virus Protease	Infection
ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC₅₀s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range .

HY-146248B

TFMU-ADPr diammonium	Poly(ADP-ribose) Glycohydrolase (PARG) SARS-CoV Protease Activated Receptor (PAR)	Metabolic Disease
TFMU-ADPr diammonium is a selective reporter substrate of SARS-CoV-2 Macro1 (IC₅₀=0.59 μM), with an excitation wavelength (λ_Ex) of 385 nm, and an emission wavelength (λ_Em) of 502 nm (or 495 nm). TFMU-ADPr diammonium can also undergo enzymatic hydrolysis with Poly(ADP-ribose) Glycohydrolase (PARG) sourced from human, Tetrahymena thermophila and ADP-ribosylhydrolase 3 from human to release fluorophores, thereby directly reporting total poly (ADP-ribose) hydrolase activity. TFMU-ADPr diammonium binds to the ADPr-binding site of SARS-CoV-2 Macro1, and its TFMU moiety inserts into the narrow hydrophobic groove of this protein. TFMU-ADPr diammonium can thus be used to evaluate small-molecule inhibitors targeting PAR hydrolases under in vitro conditions, to investigate the regulatory mechanisms of ADP-ribosyl catabolic enzymes, or to detect PAR hydrolase activity in whole-cell lysate assays. TFMU-ADPr diammonium is also applicable to COVID-19-related research .

HY-135867E

NHC-triphosphate tetraammonium 5+ Cited Publications	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV	Infection
NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-146248

TFMU-ADPr	SARS-CoV Poly(ADP-ribose) Glycohydrolase (PARG) Protease Activated Receptor (PAR)	Infection
TFMU-ADPr is a selective reporter substrate of SARS-CoV-2 Macro1 (IC₅₀=0.59 μM), with an excitation wavelength (λ_Ex) of 385 nm, and an emission wavelength (λ_Em) of 502 nm (or 495 nm). TFMU-ADPr can also undergo enzymatic hydrolysis with Poly(ADP-ribose) Glycohydrolase (PARG) sourced from human, Tetrahymena thermophila and ADP-ribosylhydrolase 3 from human to release fluorophores, thereby directly reporting total poly (ADP-ribose) hydrolase activity. TFMU-ADPr binds to the ADPr-binding site of SARS-CoV-2 Macro1, and its TFMU moiety inserts into the narrow hydrophobic groove of this protein. TFMU-ADPr can thus be used to evaluate small-molecule inhibitors targeting PAR hydrolases under in vitro conditions, to investigate the regulatory mechanisms of ADP-ribosyl catabolic enzymes, or to detect PAR hydrolase activity in whole-cell lysate assays. TFMU-ADPr is also applicable to COVID-19-related research .

HY-135867

NHC-triphosphate	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV	Infection
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-178690

MyD88-IN-4	MyD88 IFNAR	Infection Inflammation/Immunology
MyD88-IN-4 is a MyD88 inhibitor. MyD88-IN-4 exerts antiviral effects by up-regulating IFN-β, and anti-inflammatory effects by inhibiting pro-inflammatory cytokine production. MyD88-IN-4 prevents MyD88 homodimer formation and its interaction with IRF3/IRF7. MyD88-IN-4 demonstrates efficacy against encephalitic alphavirus infections by reducing viral replication and improving survival in VEEV TC-83-infected mouse models. MyD88-IN-4 can be used for the study of alphavirus infections, bacterial toxin-related diseases, and sepsis .

HY-135867A

NHC-triphosphate tetrasodium	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase	Infection
NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetrasodium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-135867D

NHC-diphosphate 1 Publications Verification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV	Infection
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .

HY-168050

SGC-NSP2PRO-1	CHIKV Virus Protease	Infection
SGC-NSP2PRO-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) nsP2 cysteine protease with an IC₅₀ value of 60 nM. SGC-NSP2PRO-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC₅₀ = 0.01 and 0.3 µM, respectively .

HY-145842

Encephalitic alphavirus-IN-1	Virus Protease	Infection Neurological Disease
Encephalitic alphavirus-IN-1 has antiviral activity for *VEEV* and EEEV with EC₅₀s of 0.24 μM and 0.16 μM, respectively. Encephalitic alphavirus-IN-1 has robust mouse plasma stability, and no obvious cytotoxicity .

HY-135867F

NHC-diphosphate triammonium 1 Publications Verification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV	Infection
NHC-diphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC-diphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-171261

CID15997213	Virus Protease	Infection
CID15997213 is a blood-brain barrier penetrating antiviral agent. CID15997213 targets the amino-terminal domain of the *VEEV* nonstructural protein 2 (nsP2). CID15997213 shows alphavirus-specific antiviral effect, inhibiting *VEEV* and Western equine encephalitis virus .

HY-175234

CHIKV nsP2 protease-IN-2	DNA/RNA Synthesis Virus Protease	Infection
CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC₅₀s of 0.5  μM and 0.9  μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC₅₀ of 120 nM for CHIKV-nLuc). CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research .

HY-159879

AAK1-IN-6	AAK1 Dengue Virus	Infection
AAK1-IN-6 (Compound 23) is an inhibitor of AP-2-associated protein kinase 1 (AAK1, IC₅₀ = 12 nM) with antiviral activity against the dengue virus (DNEV2, EC₅₀ = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC₅₀ = 0.30 μM). AAK1-IN-6 can be utilized in antiviral research .

HY-P991766

*Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57)*	Flavivirus	Infection
Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) reacts with the E2 protein of the Venezuelan equine encephalitis virus (VEEV). Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) inhibits VEEV attachment to Vero cells, viral egress, viral fusion, and LDLRAD3-D1-Fc binding. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

HY-181969

BFB78	Virus Protease	Infection
BFB78 is a blood-brain barrier-permeable nsP2 protease inhibitor. BFB78 potently and broadly inhibits the purified nsP2 proteases of various alphaviruses, with IC₅₀ values ranging from 21.6 nM (Mayaro virus; MAYV) to 130.7 nM (Chikungunya virus; CHIKV). BFB78 blocks viral replication in cell culture systems and reduces viral titers in the brains of mice. BFB78 can be used in studies related to Venezuelan equine encephalitis virus (VEEV) infection .

Cat. No.	Product Name	Type

HY-146248

TFMU-ADPr	Fluorescent Dye
TFMU-ADPr is a selective reporter substrate of SARS-CoV-2 Macro1 (IC₅₀=0.59 μM), with an excitation wavelength (λ_Ex) of 385 nm, and an emission wavelength (λ_Em) of 502 nm (or 495 nm). TFMU-ADPr can also undergo enzymatic hydrolysis with Poly(ADP-ribose) Glycohydrolase (PARG) sourced from human, Tetrahymena thermophila and ADP-ribosylhydrolase 3 from human to release fluorophores, thereby directly reporting total poly (ADP-ribose) hydrolase activity. TFMU-ADPr binds to the ADPr-binding site of SARS-CoV-2 Macro1, and its TFMU moiety inserts into the narrow hydrophobic groove of this protein. TFMU-ADPr can thus be used to evaluate small-molecule inhibitors targeting PAR hydrolases under in vitro conditions, to investigate the regulatory mechanisms of ADP-ribosyl catabolic enzymes, or to detect PAR hydrolase activity in whole-cell lysate assays. TFMU-ADPr is also applicable to COVID-19-related research .

TFMU-ADPr

Fluorescent Dye

TFMU-ADPr is a selective reporter substrate of SARS-CoV-2 Macro1 (IC₅₀=0.59 μM), with an excitation wavelength (λ_Ex) of 385 nm, and an emission wavelength (λ_Em) of 502 nm (or 495 nm). TFMU-ADPr can also undergo enzymatic hydrolysis with Poly(ADP-ribose) Glycohydrolase (PARG) sourced from human, Tetrahymena thermophila and ADP-ribosylhydrolase 3 from human to release fluorophores, thereby directly reporting total poly (ADP-ribose) hydrolase activity. TFMU-ADPr binds to the ADPr-binding site of SARS-CoV-2 Macro1, and its TFMU moiety inserts into the narrow hydrophobic groove of this protein. TFMU-ADPr can thus be used to evaluate small-molecule inhibitors targeting PAR hydrolases under in vitro conditions, to investigate the regulatory mechanisms of ADP-ribosyl catabolic enzymes, or to detect PAR hydrolase activity in whole-cell lysate assays. TFMU-ADPr is also applicable to COVID-19-related research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991766

*Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57)*	Flavivirus	Infection
Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) reacts with the E2 protein of the Venezuelan equine encephalitis virus (VEEV). Anti-Venezuelan equine encephalitis virus E2 protein Antibody (VEEV-57) inhibits VEEV attachment to Vero cells, viral egress, viral fusion, and LDLRAD3-D1-Fc binding. Recommend Isotype Controls: Mouse IgG2c kappa, Isotype Control (HY-P99981) .

NHC-triphosphate	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

NHC-triphosphate tetrasodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase
NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetrasodium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

NHC-diphosphate 1 Publications Verification	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .

NHC-diphosphate triammonium 1 Publications Verification	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV
NHC-diphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC-diphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

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VEEV

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

NaturalProducts

Natural
Products