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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
WS3
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "WS3" in MCE Product Catalog:
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WS3 is an allosteric inhibitor of 14-3-3 (14-3-3ζ: Kd = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE signaling pathway (IC50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation . WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer [3].
Cat. No.: HY-W014325
CAS No.: 39711-79-0
Synonyms: Framidice 3
Target:
Research Areas:
TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions .
Cat. No.: HY-W014325R
CAS No.: 39711-79-0
Synonyms: Framidice 3 (Standard)
Research Areas:
TRPM8 agonist WS-3 (Standard) is the analytical standard of TRPM8 agonist WS-3. This product is intended for research and analytical applications. TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions .
Cat. No.: HY-RS16419
Target:
Research Areas:
DCTN6 Human Pre-designed siRNA Set A contains three designed siRNAs for DCTN6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21546
Target:
Research Areas:
Dctn6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dctn6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10090
Target:
Research Areas:
PAX3 Human Pre-designed siRNA Set A contains three designed siRNAs for PAX3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P81461A
Synonyms: TAGLN; Transgelin; SM22; WS3-10; 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha (SM22-alpha)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
