39711-79-0
39711-79-0
Chemical Structure
TRPM8 agonist WS-3
Synonym(s): Framidice 3
- CAS No.: 39711-79-0
- Formula:C13H25NO
- Molecular Weight:211.35
IUPAC Name: N-ethyl-2-isopropyl-5-methylcyclohexane-1-carboxamide
InChIKey: VUNOFAIHSALQQH-UHFFFAOYSA-N
SMILES: CC(C)C1CCC(C)CC1C(NCC)=O
Biological Activity: TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions[1][2].
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TRPM8 agonist WS-3 | 99.35% | TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions. | ||||||||||||||||||||
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TRPM8 agonist WS-3 (Standard) | ≥98% | TRPM8 agonist WS-3 (Standard) is the analytical standard of TRPM8 agonist WS-3. This product is intended for research and analytical applications. TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions. | ||||||||||||||||||||
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References
- [1]. Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. [Content Brief]
- [2]. Moriyama H, et al. Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels. Neuropsychopharmacology. 2025 Nov;50(12):1855-1863. [Content Brief]
