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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
acyl-CoA synthetase
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "acyl-CoA synthetase" in MCE Product Catalog:
12
Target:
2
2 Cited Publications
Target:
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer .
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2 Cited Publications
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FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively .
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Cat. No.: HY-173432
CAS No.: 3111845-07-6
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LIBX-A401 is a selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor with a human IC50 values of 0.38 μM and a Kd of 0.72 μM. LIBX-A401 binds to ACSL4 in an ATP-dependent manner, stabilizes the C-terminal domain, alters the fatty acid gate region, and interacts with residues A329 and Q302 within the fatty acid binding site. LIBX-A401 exhibits anti-ferroptosis properties in cells. LIBX-A401 can be used for the researches of cancer and parkinson's disease .
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Research Areas:
5-Hydroxydecanoate sodium is a selective ATP-sensitive K + (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity .
Cat. No.: HY-W015444
CAS No.: 617-73-2
Category:
Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines .
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ESP15228 is a metabolite of Bempedoic acid (HY-12357). ESP15228 undergoes glucuronidation to form ESP15228-glucuronide. ESP15228 can form excretory ESP15228-taurine conjugate in feces. ESP15228-CoA is a selective hepatic ATP citrate lyase inhibitor. ESP15228 can be used in the research of hypercholesterolemia .
Synonyms: Linoleoyl Coenzyme A; 9(Z),12(Z)-Octadecadienoyl Coenzyme A; 9Z,12Z-Octadecadienoyl-CoA; 9Z,12Z-Octadecadienoyl-coenzyme A
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Linoleoyl-CoA (Linoleoyl Coenzyme A) is a long-chain acyl-CoA ester formed from linoleic acid and coenzyme A. Linoleoyl-CoA serves as a key activated fatty acid intermediate involved in lipid biosynthesis, fatty acid β-oxidation and the regulation of cellular metabolism. Elevated levels of Linoleoyl-CoA in skeletal muscle correlate with increased lipid availability, insulin resistance and metabolic dysregulation and can be used for activity assays of acyl-CoA synthetases, acyltransferases and fatty acid metabolic enzymes .
Cat. No.: HY-155852
CAS No.: 412328-25-7
Cat. No.: HY-W015444R
CAS No.: 617-73-2
Cat. No.: HY-117651R
CAS No.: 16518-94-8
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Research Areas:
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
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Cat. No.: HY-N7814S
CAS No.: 2692623-90-6
Synonyms: 2-Hydroxyhexadecanoic acid-d30
Research Areas:
2-Hydroxypalmitic acid-d30 (2-Hydroxyhexadecanoic acid-d30) is the d30 labeled 2-Hydroxypalmitic acid (HY-N7814). 2-Hydroxypalmitic acid is an intermediate in the phytosphingosine metabolic pathway. 2-Hydroxypalmitic acid is exclusively incorporated into sphingolipids and not used for other lipids. 2-Hydroxypalmitic acid promotes the production of odd-carbon phosphatidylcholine species. 2-Hydroxypalmitic acid is applicable to studies of Saccharomyces cerevisiae infection .
Cat. No.: HY-P87353
Synonyms: ACS 1 antibody; ACS1 antibody; ACSL 1 antibody; ACSL1 antibody; ACSL1_HUMAN antibody; acyl CoA synthetase 1 antibody; acyl CoA synthetase long chain family member 1 antibody; acyl-CoA synthetase 1 antibody; FACL 1 antibody; FACL 2 antibody
Cat. No.: HY-P77206
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC27A4; acyl-CoA synthetase Very Long Chain Family Member 4; Solute Carrier Family 27 Member 4; Very Long-Chain acyl-CoA synthetase 4; ACSVL4; Long-Chain-Fatty-Acid--CoA Ligase; FATP4; Fatty Acid Transport Protein 4; Long-Chain Fatty Acid Transport Prote
Species:
Human
Source:
HEK293
Cat. No.: HY-P74435
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AACS; FLJ12389; Acetoacetyl-CoA synthetase; Homolog Of C. Elegans Supressor Of Ras 5 (Sur-5); ACSF1; Alternative Protein AACS; acyl-CoA synthetase Family Member 1; Acetoacetate-CoA Ligase; SUR-5; AACS Protein; Protein Sur-5 Homolog
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
