4 Results for "

bunyaviruses

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "bunyaviruses" in MCE Product Catalog:

1
Licoflavone C
Licoflavone C
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1 Cited Publications
Cat. No.: HY-N4183
CAS No.: 72357-31-4
Category:  

Flavonoids Flavones Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Apoptosis Caspase Estrogen Receptor/ERR

Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its Kd value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .
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D4-Ribavirin
D4-Ribavirin
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Cat. No.: HY-124224
CAS No.: 131922-28-6
Target:  

Dengue Virus Flavivirus

Research Areas:  

Infection

D4-Ribavirin (Compound 4) is a deoxygenated ribavirin analogue. D4-Ribavirin has antiviral property in vitro against the RNA-containing bunyaviruses–Rift Valley Fever () with an IC50 of 61 μg/mL .
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Pronaphthalide A
Pronaphthalide A
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Cat. No.: HY-N21711
CAS No.: 1624617-93-1
Category:  

Acanthaceae Extract Conioselinum smithii (H. Wolff) Pimenov & Kljuykov Lignans Phenylpropanoids Plants

Target:  

Biochemical Assay Reagents

Pronaphthalide A is a cytotoxic agent and an inhibitor of SFTSV glycoprotein Gn (domain B) (Kd = 0.74 mM). It blocks viral binding and internalization by binding to the conserved B domain of SFTSV Gn, thereby inhibiting SFTSV infection at the viral entry stage, and exhibits broad-spectrum antiviral activity against bunyaviruses. Pronaphthalide A can be used for research on gastric cancer, severe fever with thrombocytopenia syndrome, and HIV/AIDS .
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Procumbenoside I
Procumbenoside I
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Cat. No.: HY-N21657
CAS No.: 2243471-10-3
Category:  

Acanthaceae Extract Conioselinum smithii (H. Wolff) Pimenov & Kljuykov Lignans Phenylpropanoids Plants

Target:  

VSV SARS-CoV Influenza Virus Arenavirus

Procumbenoside I is a naturally derived broad-spectrum antiviral agent targeting the SFTSV glycoprotein Gn. Procumbenoside I binds to the conserved B domain of SFTSV Gn, blocking the binding and internalization steps during viral entry. Procumbenoside I inhibits the entry of VSV, H5N1, and SARS-CoV-2 pseudoviral particles, while exhibiting antiviral activity against bunyaviruses such as LCMV and WELV. Procumbenoside I protects mice against lethal SFTSV challenge, reducing mortality and alleviating pathological damage. Procumbenoside I is useful for research related to viral infections .
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