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- Conioselinum smithii (H. Wolff) Pimenov & Kljuykov
Conioselinum smithii (H. Wolff) Pimenov & Kljuykov
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Conioselinum smithii (H. Wolff) Pimenov & Kljuykov (28)
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- Formula: C21H16O6
- Molecular Weight: 364.35
Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation.
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- Formula: C22H20O7
- Molecular Weight: 396.40
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- Formula: C26H24O12
- Molecular Weight: 528.47
Procumbenoside I is a naturally derived broad-spectrum antiviral agent targeting the SFTSV glycoprotein Gn. Procumbenoside I binds to the conserved B domain of SFTSV Gn, blocking the binding and internalization steps during viral entry. Procumbenoside I inhibits the entry of VSV, H5N1, and SARS-CoV-2 pseudoviral particles, while exhibiting antiviral activity against bunyaviruses such as LCMV and WELV. Procumbenoside I protects mice against lethal SFTSV challenge, reducing mortality and alleviating pathological damage. Procumbenoside I is useful for research related to viral infections.
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- Formula: C23H22O7
- Molecular Weight: 410.42
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- Formula: C32H34O16
- Molecular Weight: 674.60
Procumbenoside B is an arylnaphthalene lignan glycoside found in Justicia procumbens.
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- Formula: C28H28O13
- Molecular Weight: 572.51
Justicidinoside B is an arylnaphthalene lignan glycoside that can be found in the whole plant of Justicia procumbens, and it contains a β-D-glucopyranosyl sugar moiety.
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- Formula: C48H78O18
- Molecular Weight: 943.13
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- Formula: C21H16O7
- Molecular Weight: 380.35
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- Formula: C20H14O6
- Molecular Weight: 350.33
Jusneesiin is a (1R)-angularly fused β-apolignan discovered from Justicia neesii.
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- Formula: C20H14O7
- Molecular Weight: 366.33
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- Formula: C36H40O19
- Molecular Weight: 776.70
Ciliatoside A is a naturally bioactive compound that exhibits significant anti-inflammatory, antiviral, and neuroprotective activities. Ciliatoside A serves as a mitophagy inducer and NLRP3 inflammasome inhibitor, activating AMPK, SIRT1, and the PINK1/Parkin axis, and inhibiting pyroptosis and apoptosis. Ciliatoside A promotes autophagic flux, autophagosome-lysosome fusion, mTOR inhibition, and p62-dependent HBc degradation; reduces Aβ aggregation, plaque deposition, microglial/astrocyte activation, and bacterial load; and maintains neuronal integrity, mitochondrial membrane potential, and ATP production. Ciliatoside A is used in research on Alzheimer's disease, Klebsiella pneumoniae-induced pneumonia, hepatitis B virus infection, and inflammation.
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- Formula: C22H20O7
- Molecular Weight: 396.40
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- Formula: C36H40O19
- Molecular Weight: 776.70
Procumbenoside E is an arylnaphthalene lignan glycoside compound discovered from Justicia procumbens, and it possesses an arylnaphthalene lignan skeleton and a diphyllin structure.
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- Formula: C41H48O23
- Molecular Weight: 908.81
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- Formula: C31H32O15
- Molecular Weight: 644.58
Procumbenoside A is a lignan glycoside discovered in Justicia procumbens. Procumbenoside A inhibits HIV-1 replication with an IC50 of 4.95 μM. Procumbenoside A exerts cytotoxic effects on various cancer cells. Procumbenoside A induces Cu (II)-mediated strand breaks in supercoiled plasmid DNA, generating the relaxed circular DNA form, while no linear form is detected. Procumbenoside A is used in studies related to liver cancer, colon adenocarcinoma, and HIV-1 infection.
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- Formula: C27H36O9
- Molecular Weight: 504.58
8,8'-Lignan-3,3',4,4',5,9,9'-heptol is a dibenzylbutane-type lignan that can be found in Justicia procumbens. It is useful for research related to lignan components and natural product chemistry.
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- Formula: C26H24O12
- Molecular Weight: 528.47
Justalakonin is an arylnaphthalene glycoside that is found in Justicia purpurea. Justalakonin exhibits no significant inhibitory effects on lipid peroxidation, COX‑1, or the proliferation of various tumor cells, but possesses COX-2 inhibitory activity.
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- Formula: C21H14O7
- Molecular Weight: 378.33
Justicidin F (Taiwanin E methyl ether) is a lignan found in Justicia procumbens Linn. var. leucantha Honda.
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