303084-57-3
Chemical Structure
Ciliatoside A
- CAS No.: 303084-57-3
- Formula:C36H40O19
- Molecular Weight:776.70
IUPAC Name: 9-(benzo[d][1,3]dioxol-5-yl)-4-(((2S,3R,4R)-4-hydroxy-3-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-4-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydrofuran-2-yl)oxy)-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one
InChIKey: WTNBRCRYRLAZFO-DSUIHCPPSA-N
SMILES: O=C1C2=C(C=3C(C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O)CO5)[C@](CO[C@H]6[C@H](O)[C@@H](O)[C@H](O)CO6)(O)CO4)=C2CO1)=CC(OC)=C(OC)C3)C=7C=C8C(=CC7)OCO8
Biological Activity: Ciliatoside A is a naturally bioactive compound that exhibits significant anti-inflammatory, antiviral, and neuroprotective activities. Ciliatoside A serves as a mitophagy inducer and NLRP3 inflammasome inhibitor, activating AMPK, SIRT1, and the PINK1/Parkin axis, and inhibiting pyroptosis and apoptosis. Ciliatoside A promotes autophagic flux, autophagosome-lysosome fusion, mTOR inhibition, and p62-dependent HBc degradation; reduces Aβ aggregation, plaque deposition, microglial/astrocyte activation, and bacterial load; and maintains neuronal integrity, mitochondrial membrane potential, and ATP production. Ciliatoside A is used in research on Alzheimer's disease, Klebsiella pneumoniae-induced pneumonia, hepatitis B virus infection, and inflammation[1][2][3][4][5].
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Ciliatoside A | Ciliatoside A is a naturally bioactive compound that exhibits significant anti-inflammatory, antiviral, and neuroprotective activities. Ciliatoside A serves as a mitophagy inducer and NLRP3 inflammasome inhibitor, activating AMPK, SIRT1, and the PINK1/Parkin axis, and inhibiting pyroptosis and apoptosis. Ciliatoside A promotes autophagic flux, autophagosome-lysosome fusion, mTOR inhibition, and p62-dependent HBc degradation; reduces Aβ aggregation, plaque deposition, microglial/astrocyte activation, and bacterial load; and maintains neuronal integrity, mitochondrial membrane potential, and ATP production. Ciliatoside A is used in research on Alzheimer's disease, Klebsiella pneumoniae-induced pneumonia, hepatitis B virus infection, and inflammation. | |||||||||||||||||||||
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References
- [1]. Guo M, et al. Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2025 Sep;145:156928.
- [2]. Zhu J, et al. Ciliatoside A Improves Klebsiella pneumoniae-Induced Pneumonia by Modulating Mitochondrial Autophagy via the SIRT1/PINK1/Parkin Pathway. Clinical and experimental pharmacology & physiology. 2026 May;53(5):e70125. [Content Brief]
- [3]. Day SH, et al. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. Journal of natural products. 2002 Mar;65(3):379-81. [Content Brief]
- [4]. Fang R, et al. Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy. Antiviral research. 2023 Jan;209:105482.
- [5]. Day SH, et al. New lignan glycosides with potent antiinflammatory effect, isolated from Justicia ciliata. Journal of natural products. 2000 Nov;63(11):1560-2. [Content Brief]
