Justalakonin
Justalakonin is an arylnaphthalene glycoside that is found in Justicia purpurea. Justalakonin exhibits no significant inhibitory effects on lipid peroxidation, COX‑1, or the proliferation of various tumor cells, but possesses COX-2 inhibitory activity.
For research use only. We do not sell to patients.
- CAS No.: 602331-39-5
- Formula: C26H24O12
- Molecular Weight:528.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
COX-2 |
In Vitro
Justalakonin undergoes acid hydrolysis to cleave the β‑D‑glucosyl bond, yielding aglycone 2a and glucose[1].
Justalakonin (compound 5) (25 μg/mL) exhibits no significant lipid peroxidation inhibitory activity in the SLPC LUV assay; it shows no significant COX-1 inhibitory activity; and it displays no significant antiproliferative activity against the AGS, HCT-116, MCF-7, NCI-H460, and SF-268 human cancer cell lines[2].
Justalakonin (25 μg/mL) exhibits moderate COX-2 inhibitory activity, with an inhibition rate of 45-60%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human gastric (AGS), colon (HCT-116), breast (MCF-7), lung (NCI-H460), and central nervous system (SF-268) cancer cell lines
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Concentration:25 μg/mL
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Incubation Time:48 h
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Result:Did not reach the threshold for notable tumor cell proliferation inhibitory activity at 25 μg/mL across all tested cell lines.
Chemical Information
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CAS No. 602331-39-5
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Molecular Weight 528.47
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Formula C26H24O12
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SMILES
O=C1C2=C(C3=C(C(OC)=C2CO1)C=C4C(=C3)OCO4)C5=CC(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)=C(O)C=C5
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Justalakonin Related Classifications
HY-N21658 Related Classifications
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