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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
carbonic anhydrase IX (CAIX)
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "carbonic anhydrase IX (CAIX)" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .
1
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Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis .
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Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .
Cat. No.: HY-174232
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Research Areas:
EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC50 values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer .
Cat. No.: HY-175223
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CAIX-IN-4 (Compound 8b) is a selective carbonic anhydrase IX (CAIX) inhibitor with an IC50 value of 0.32 μM. CAIX-IN-4 is promising for research of cancers such as renal cell carcinoma .
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ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC50 values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .
Cat. No.: HY-179022
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CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC50 values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as lung cancer .
Cat. No.: HY-170893
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CAIX/CAXII-IN-4 (Compound 7h) is the inhibitor for carbonic anhydrase (CA) that binds CA IX, CA XII and CA II with Ki of 1.324 μM, 0.435 μM and 3.035 μM. CAIX/CAXII-IN-4 exhibits board-spectrum antitumor efficacy, inhibits the proliferation of CNS cancer U251 with GI50 of 0.361 μM .
Cat. No.: HY-125575
CAS No.: 1380411-57-3
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FC11409B is an ureido-sulfamate carbonic anhydrase IX (CAIX) inhibitor. FC11409B inhibits proliferation and migration of breast cancer cell lines in both hypoxic (0.5% O2) and normoxic conditions (21% O2). FC11409B also inhibits 3D spheroid of breast cancer subtypes invasion. FC11409B is promising for research of breast and ovarian cancers .
Cat. No.: HY-P11737
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Cat. No.: HY-163691
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Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model .
Cat. No.: HY-184789
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CAIX-IN-18 is a competitive carbonic anhydrase IX (CA IX) inhibitor with a Ki value of 1.76 μM. CAIX-IN-18 can be used for the research of colorectal cancer .
Cat. No.: HY-P70064
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CA9; Carbonate Dehydratase IX; carbonic anhydrase 9; carbonic Dehydratase; CAIX; Membrane Antigen MN; MN; P54/58N; carbonic anhydrase IX; CA-IX; Renal Cell Carcinoma-Associated Antigen G250; PMW1; RCC-Associated Protein G250; carbonic anhydrase; RCC-Assoc
Species:
Human
Source:
HEK293
Cat. No.: HY-P72863
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CA9; Carbonate Dehydratase IX; carbonic anhydrase 9; carbonic Dehydratase; CAIX; Membrane Antigen MN; MN; P54/58N; carbonic anhydrase IX; CA-IX; Renal Cell Carcinoma-Associated Antigen G250; PMW1; RCC-Associated Protein G250; carbonic anhydrase; RCC-Assoc
Species:
Human
Source:
HEK293
Cat. No.: HY-P75454
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CA9; Carbonate Dehydratase IX; carbonic anhydrase 9; carbonic Dehydratase; CAIX; Membrane Antigen MN; MN; P54/58N; carbonic anhydrase IX; CA-IX; Renal Cell Carcinoma-Associated Antigen G250; PMW1; RCC-Associated Protein G250; carbonic anhydrase; RCC-Assoc
Species:
Canine
Source:
HEK293
Cat. No.: HY-P77585
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CA9; Carbonate Dehydratase IX; carbonic anhydrase 9; carbonic Dehydratase; CAIX; Membrane Antigen MN; MN; P54/58N; carbonic anhydrase IX; CA-IX; Renal Cell Carcinoma-Associated Antigen G250; PMW1; RCC-Associated Protein G250; carbonic anhydrase; RCC-Assoc
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P700882
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CA9; Carbonate Dehydratase IX; carbonic anhydrase 9; carbonic Dehydratase; CAIX; Membrane Antigen MN; MN; P54/58N; carbonic anhydrase IX; CA-IX; Renal Cell Carcinoma-Associated Antigen G250; PMW1; RCC-Associated Protein G250; carbonic anhydrase; RCC-Assoc
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P75455
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CA9; Carbonate Dehydratase IX; carbonic anhydrase 9; carbonic Dehydratase; CAIX; Membrane Antigen MN; MN; P54/58N; carbonic anhydrase IX; CA-IX; Renal Cell Carcinoma-Associated Antigen G250; PMW1; RCC-Associated Protein G250; carbonic anhydrase; RCC-Assoc
Species:
Canine
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
