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Results for "

cluster of differentiation 47 (CD47)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CD1 (1) CD19 (1) CD28 (1) CD3 (3) CD47 (54) CD73 (1) 5-HT Receptor (3) Akt (2) AMPK (1) Amylin Receptor (1) Amyloid-β (3) Antibiotic (2) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (10) Aryl Hydrocarbon Receptor (3) ATP Synthase (1) Autophagy (1) Bacterial (7) Bcr-Abl (4) Biochemical Assay Reagents (8) Cadherin (2) Calcium Channel (2) Carboxylesterase (CES) (1) CGRP Receptor (2) Claudin (2) Cuproptosis (3) DNA/RNA Synthesis (3) Drug Derivative (3) Drug Intermediate (3) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (9) Exosomes (3) Ferroptosis (3) Folate Receptor (FR) (1) Fungal (2) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (1) HSP (1) HSV (1) Huntingtin (1) iGluR (1) IKZF Family (1) Insecticide (1) Integrin (3) Interleukin Related (4) Isotope-Labeled Compounds (1) Kinesin (2) LDLR (2) Liposome (6) MHC (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitosis (1) mRNA (1) nAChR (1) Orexin Receptor (OX Receptor) (1) PAK (1) Parasite (3) PARP (1) PD-1/PD-L1 (4) PGC-1α (1) Phospholipase (1) PI3K (2) Polo-like Kinase (PLK) (1) PROTACs (1) Reactive Oxygen Species (ROS) (6) Reference Standards (4) SARS-CoV (2) Small Interfering RNA (siRNA) (3) TGF-β Receptor (2) Thrombopoietin Receptor (3) Tie (2) TNF Receptor (3) Transmembrane Glycoprotein (3) TREM receptor (1) TRP Channel (1) Virus Protease (1) Zinc Finger Protein (1) α-synuclein (1)
By Research Areas:	Cancer (83) Cardiovascular Disease (3) Infection (20) Inflammation/Immunology (37) Metabolic Disease (10) Neurological Disease (12)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Gene Editing (1) siRNAs (3)

149

Inhibitors & Agonists

Screening Libraries

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Targets Recommended: CD3 CD6 CD2 CD47 Neprilysin FLT3 Anaplastic lymphoma kinase (ALK) P-glycoprotein CD1 CD38 CD28 CD19 CD20 CD22 Transferrin Receptor P-selectin CD276/B7-H3 CD73 c-Kit LAG-3 L-Selectin CTLA-4 ALCAM/CD166 E-Selectin Scavenger Receptor Class B type I (SR-BI） Tim3 CD44 CD74 Human leukocyte immunoglobulin (Ig)-like receptors (LILR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12040

Elesclomol Maximum Cited Publications 115 Publications Verification STA-4783	Reactive Oxygen Species (ROS) Apoptosis Cuproptosis	Cancer
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-P99029

Magrolimab 3 Publications Verification Hu5F9-G4	CD47	Cancer
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab, an IgG4 isotype, lacks ADCC function and exhibits relatively weak ADCP effector function. Magrolimab can be used for the study of malignant bone tumors and breast cancer .

HY-16438

RRx-001 15+ Cited Publications Nibrozetone	CD47 Apoptosis Parasite	Infection Inflammation/Immunology Cancer
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating *CD47* and SIRP-α . RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity .

HY-P99021

Galcanezumab 1 Publications Verification LY 2951742	CGRP Receptor	Neurological Disease
Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research .

HY-P99706

Ligufalimab 1 Publications Verification AK 117	CD47 Interleukin Related	Cancer
Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity .

HY-P99175

KWAR 23	CD47	Cancer
KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research .

HY-P99950

Evorpacept ALX148	CD47	Cancer
Evorpacept (ALX148) is a high-affinity *CD47*-blocking fusion protein with an inactive human immunoglobulin Fc region. Evorpacept binds to CD47, blocks the interaction of the CD47-SIRPα immune checkpoint, and inhibits the binding of wild-type SIRPα to CD47. Evorpacept is applicable to research related to acute myeloid leukemia .

HY-P99533

Urabrelimab 1 Publications Verification SRF-231; SRF231	CD47 Interleukin Related	Cancer
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-W698249

Ferrous gluconate	Ferroptosis Bacterial	Cardiovascular Disease Infection
Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe ²⁺ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to E. coli infection and iron deficiency anemia .

HY-P99777

Ontorpacept 1 Publications Verification TTI-621	CD47	Cancer
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a *CD47-blocking* checkpoint inhibitor with antitumor activity .

HY-P990858

*Anti-CD47* Antibody (B6.H12)**	CD47	Cancer
Anti-CD47 Antibody (B6.H12) is a kind of mouse IgG1 κ chimeric antibody, targeting to human *CD47. Anti-CD47* Antibody (B6.H12) blocks CD47 interactions with SIRPα. Anti-CD47 Antibody (B6.H12) inhibits cell proliferation, cell migration and invasion. Anti-CD47 Antibody (B6.H12) increases macrophage phagocytosis. Anti-CD47 Antibody (B6.H12) shows potent anti-tumor effect in various tumor models, such as osteosarcoma .

HY-P990033

Anzurstobart CC-95251; BMS-986351	CD47	Cancer
Anzurstobart is a *CD47/SIRPα inhibitor with human SIRPα K_d of 0.0541 nM and human SIRPα IC₅₀* of 100 nM. Anzurstobart binds SIRPα at a CD47-overlapping site, blocks CD47-SIRPα interactions, inhibits CD47-SIRPα axis signaling, and binds across 6 prevalent human SIRPα haplotypes. Anzurstobart binds SIRPγ and inhibits CD47-SIRPγ interactions. Anzurstobart can be used for the research of non-Hodgkin's lymphoma, colorectal cancer, squamous cell carcinoma of the head and neck, diffuse large B-cell lymphoma, and advanced solid and hematologic malignancies .

HY-18570B

1-Naphthaleneacetic acid,suitable for plant cell culture NAA	Biochemical Assay Reagents	Others
1-Naphthaleneacetic acid,suitable for plant cell culture (NAA) is a plant growth hormone. 1-Naphthaleneacetic acid,suitable for plant cell culture promotes plant growth and induces root cluster formation. Naphthaleneacetic acid,suitable for plant cell culture is applicable for plant cell culture .

HY-P990131

*Anti-Mouse CD47/IAP Antibody (MIAP301)* 1 Publications Verification	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse *CD47/IAP* IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis .

HY-P99172

CC-90002	CD47 Interleukin Related	Cancer
CC-90002 is a *humanized anti-CD47* monoclonal antibody (mAb)*. CC-90002 has a high affinity for binding to CD47* with a subnanomolar K_d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors .

HY-136780

SEN177	Amyloid-β Apoptosis CD47 Huntingtin	Neurological Disease Cancer
SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The K_i of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC₅₀ is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases .

HY-P991526

M701	CD3	Cancer
M701 is a T-cell engager bispecific humanized antibody targeting epithelial cell adhesion molecule (EpCAM) and cluster of differentiation 3 (CD3). M701 binds to EpCAM on tumor cells and CD3 on T cells, thereby linking the two cell populations to achieve targeted cytotoxicity and T cell-mediated cytotoxicity. M701 is applicable to research related to advanced epithelial solid tumors .

HY-P991023

Safimestomig 6MW3211	CD47 PD-1/PD-L1	Cancer
Safimestomig (6MW3211) is an *CD47/PD-L1*-targeting bispecific antibody. Safimestomig blocks CD47-mediated 'don't eat me' signaling and selectively binds to CD47 on tumor cells. Safimestomig blocks PD-L1-mediated immune checkpoint signaling. Safimestomig can be used for the research of cancer .

HY-18377

Bioymifi 1 Publications Verification DR5 Activator	TNF Receptor Apoptosis	Cancer
Bioymifi (DR5 Activator), a potent TRAIL receptor DR5 activator, binds to the extracellular domain (ECD) of DR5 with a K_d of 1.2 μM. Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis .

HY-P99026

Lemzoparlimab 1 Publications Verification TJ011133; TJC4	CD47	Cancer
Lemzoparlimab (TJ011133; TJC4) is a humanized anti-CD47 IgG4 antibody. Lemzoparlimab has a strong anti-tumor activity .

HY-P0144

Thrombospondin-1 (1016-1023) (human, bovine, mouse)	CD47 Apoptosis	Inflammation/Immunology
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a *CD47* agonist peptide .

HY-P990132

*Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)*	CD47	Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human *CD47/IAP* IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair .

HY-P3970A

KRFK TFA 4 Publications Verification	TGF-β Receptor	Inflammation/Immunology
KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach .

HY-162386

UM4118	Cuproptosis Mitochondrial Metabolism	Cancer
UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .

HY-148978

18:0,18:1 PS sodium	Exosomes Endogenous Metabolite Liposome	Metabolic Disease
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage .

HY-115983

DMUP	CD47 Apoptosis	Cancer
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity .

HY-P3970

KRFK	TGF-β Receptor	Inflammation/Immunology
KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach .

HY-RS02250

CD47 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD47	Others
CD47 Human Pre-designed siRNA Set A contains three designed siRNAs for CD47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD47 Human Pre-designed siRNA Set A CD47 Human Pre-designed siRNA Set A

HY-118090A

D-γ-Glutamyl-D-glutamic acid D-γ-Glu-Glu; H-D-γ-Glu-Glu-OH	Endogenous Metabolite	Others
D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .

HY-P99903

Simridarlimab IBI-322	PD-1/PD-L1 CD47	Inflammation/Immunology Cancer
Simridarlimab (IBI-322) is a bispecific antibody targeting PD-L1 and *CD47. Simridarlimab attenuates CD47* activity in monovalent binding and blockes PD-L1 activity in bivalent binding. Simridarlimab selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro .

HY-P2632

RAD16-I RADA16	Biochemical Assay Reagents	Neurological Disease
RAD16-I (RADA16) is a non-directed self-assembling peptide hydrogel. Under physiological conditions, RAD16-I spontaneously forms a three-dimensional nanofiber network that mimics the extracellular matrix, and possesses excellent properties such as high water content, biocompatibility and degradability. RAD16-I serves as an ideal scaffold for three-dimensional cell culture. RAD16-I not only maintains cell viability and induces self-organization, but also supports cell adhesion, proliferation, differentiation and insulin secretion, effectively stabilizes islet clusters and promotes directed differentiation of the cardiac lineage. RAD16-I can construct a cell-friendly nano-microenvironment for research related to diseases such as myocardial infarction and diabetes .

HY-143224B

NCGC00138783 TFA	CD47	Cancer
NCGC00138783 TFA is a selective inhibitor targeting CD47/SIRPα axis, with an IC₅₀ of 50 μM. NCGC00138783 TFA directly blocks the interaction between CD47 and SIRPα axis .

HY-P990707

Maplirpacept TTI-622; PF-07901801	CD47	Inflammation/Immunology
Maplirpacept (TTI-622; PF-07901801) is a fusion protein consisting of the *CD47*-binding domain of human SIRPα linked to the Fc region of human IgG4. Maplirpacept enhances phagocytosis by blocking CD47 .

HY-P10420

RS17	CD47 Interleukin Related	Cancer
RS17 is an anti-tumor peptide designed to bind specifically to the *CD47* molecule and block the interaction between *CD47* and its ligand, SIRPα, on the surface membrane of macrophages. The main regulatory mechanism of RS17 is to prevent *CD47* from transmitting selective phagocytosis signals to SIRPα by binding to *CD47*, so that macrophages do not recognize tumor cells as their own tissue, but phagocytose them as foreign substances, thereby inhibiting immune escape of tumor cells. RS17 can be used to study the mechanism of anti-tumor response and immune escape .

HY-P990694

Zeripatamig TG-1801	CD19 CD47	Inflammation/Immunology
Zeripatamig is an anti-CD19/CD47 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991085

HX009	PD-1/PD-L1	Cancer
HX009 is a bispecific antibody targeting PD1 and *CD47, but with weakened CD47* binding. HX009 blocks the functional of PD1/CD47. HX009 can be used for the study of non-Hodgkin’s lymphoma (NHL) .

HY-P11097

Pep-20	CD47	Cancer
Pep-20 is a CD47/SIRPα blocking peptide with K_D values of 2.91 and 3.63 μM for human and mouse CD47, respectively. IC₅₀ values for blocking the human and mouse CD47/SIRPα interaction are 24.56 and 12.03 μM, respectively. Pep-20 has antitumor activity .

HY-P991057

STI-6643	CD47	Cancer
STI-6643 is a fully human IgG4 antibody that targets *CD47. STI-6643 blocks CD47-SIRP*α interaction, and enables macrophage-mediated phagocytosis of tumor cells. STI-6643 shows anti-tumor activity in mouse lymphoma xenograft models. STI-6643 can be used for the research of Burkitt's lymphoma, solid tumors, relapsed or refractory tumors, and lymphoma. The isotype control for STI-6643 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990289

Anti-Mouse CD172a Antibody (P84)	Transmembrane Glycoprotein	Infection
Anti-Mouse CD172a Antibody (P84) is a rat-derived anti-mouse CD172a IgG1 κ type antibody inhibitor. Anti-Mouse CD172a Antibody (P84) blocks CD47-SIRPα interaction and thereby augments cell phagocytosis. Anti-Mouse CD172a Antibody (P84) can be used for the researches of infection and immunology, such as salmonella typhimurium infection .

HY-143224

NCGC00138783	CD47	Cancer
NCGC00138783 is a selective inhibitor targeting CD47/SIRPα axis, with an IC₅₀ of 50 µM. NCGC00138783 directly blocks the interaction between CD47 and SIRPα axis .

HY-169579

PLK1-IN-11	Polo-like Kinase (PLK)	Cancer
PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor, with IC₅₀ of 1 μM. PLK1-IN-11 can be used in research on a variety of cancers, including pancreatic, ovarian, breast, and non-small cell lung carcinoma .

HY-P3968

Thrombospondin-1 (1016-1021) (human, bovine, mouse)	CD47	Others
Thrombospondin-1 (1016-1021) (human, bovine, mouse), a Thrombospondin-1-derived peptide, is a truncated peptide devoid of CD47-binding activity .

HY-151132

Glutaminyl cyclases-IN-1 IsoQC-IN-1	CD47	Cancer
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC₅₀ values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .

HY-P11205A

Cys-PKHB1 TFA Cys-txCD47 TFA	CD47 Reactive Oxygen Species (ROS) Thrombopoietin Receptor	Inflammation/Immunology Cancer
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, a *CD47* agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca ⁺ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death .

HY-RS16548

Cd47 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd47 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd47 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd47 Mouse Pre-designed siRNA Set A Cd47 Mouse Pre-designed siRNA Set A

HY-RS22981

Cd47 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd47 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd47 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd47 Rat Pre-designed siRNA Set A Cd47 Rat Pre-designed siRNA Set A

HY-P991062

Gentulizumab Gensci-059	CD47	Cancer
Gentulizumab (Gensci-059) is a humanized IgG4 antibody that targets *CD47. Gentulizumab displays strong binding to CD47* in both human and monkey, and effectively inhibits the CD47-SIRPα interaction. Gentulizumab exhibits a potent antitumor activity. The isotype control for Gentulizumab can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990723

Timdarpacept	CD47	Cancer
Timdarpacept (DNL310) is a recombinant SIRPa-Fc fusion protein that can activate macrophages to enhance anti-tumor activity by blocking CD47-SIRPa .

HY-P991560

TQB-2928	CD47	Cancer
TQB-2928 is a monoclonal antibody against *CD47*, which can be used in the study of cancer.

HY-P991027

Spevatamig PT-886	CD47	Inflammation/Immunology
HY-P991027 is an *CD47/CLDN18*-targeting (H-γ1_L-κ)_(H-γ1_L-κ) type bispecific antibody .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17409

Nystatin 50+ Cited Publications	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Mammalian Cell Culture Disease Research Disease Research Fields Source Classification	Fungal Antibiotic Apoptosis Bacterial
Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-N3018

Isomaltose 6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Parasite
Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose) is a glucose disaccharide. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection .

HY-N3686

D-Arabitol	Structural Classification Endogenous metabolite Saccharides Source Classification	AMPK PGC-1α
D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research .

HY-148978

18:0,18:1 PS sodium	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Lipid Source Classification	Exosomes Endogenous Metabolite Liposome
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage .

HY-N10917

Xanthohumol I	Structural Classification Humulus lupulus L. Phenols Polyphenols Plants Moraceae Source Classification	Drug Derivative
Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .

HY-N11128

Solidagonic acid	Structural Classification Terpenoids Diterpenoids Plants Compositae Petalostemun purpureum Source Classification	Kinesin
Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma .

HY-N12498

Aureonuclemycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Aureonuclemycin can be isolated from Staphylococcus aureus to obtain its biosynthetic gene cluster. Aureonuclemycin exists in two forms: Type A and Type B. Aureonuclemycin A is a nucleoside antibiotic that is structurally similar to herbicides and contains adenine. Aureonuclemycin B contains 5′-deoxyadenosine and exhibits antibacterial activity. Aureonuclemycin can be used in the research of bacterial leaf blight in rice, citrus canker, and bacterial leaf spot in rice. .

HY-116681

Aflavarin	Microorganisms Coumarins Phenylpropanoids Source Classification	Insecticide
Aflavarin is produced from cluster 39 expressed mainly in sclerotia. Aflavarin exhibits anti-insectan activity .

HY-121034

Acaterin	Natural Products Microorganisms Source Classification	Bacterial
Acaterin is a compound isolated from Pseudomonas. Its biosynthetic gene cluster has been identified, and related studies have proposed its biosynthetic pathway. Comparative transcriptomics has shown that its formation is related to the bacterial regulatory network.

HY-148978R

18:0,18:1 PS sodium (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Exosomes Endogenous Metabolite Liposome
Resorantel (Standard) is the analytical standard of Resorantel. This product is intended for research and analytical applications. 18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage .

HY-149036

PAA5	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Ferroptosis Endogenous Metabolite Reactive Oxygen Species (ROS)
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .

HY-N3018R

Isomaltose (Standard) 6-O-α-D-Glucopyranosyl-D-glucose (Standard); D-Isomaltose (Standard)	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Microorganisms Endogenous metabolite Saccharides Source Classification	Reference Standards Endogenous Metabolite Parasite
Isomaltose (Standard) is the analytical standard of Isomaltose (HY-N3018). This product is intended for research and analytical applications. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection .

HY-N19180

Hancockiamide C	Structural Classification Alkaloids Piperidine Alkaloids Microorganisms Source Classification	Drug Derivative
Hancockiamide C is a phenylacetic piperazine natural products found in Aspergillus hancockii. Hancockiamide C is synthesized via the hkm biosynthetic gene cluster, involving NRPS Hkm11 and the acetyltransferase Hkm3. Hancockiamide C inhibits seed germination of Arabidopsis thaliana (MIC = 6.3 μg/mL), but shows no activity against Eragrostis tef seeds .

Cat. No.	Product Name	Chemical Structure

HY-12040S

Elesclomol-d2

Elesclomol-d₂ (STA-4783-d₂) is a deuterium labeled Elesclomol (HY-12040). Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

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