Galcanezumab
Based on 1 publication(s) in Google Scholar
Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 1578199-75-3
- Molecular Weight:145.5 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Galcanezumab
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Biological Activity
Human IgG4 kappa
Human
CALCA/CGRP
Galcanezumab inhibits human or rat CGRP-induced cAMP production in SK-N-MC cell with IC50s of 0.35 nM and 1.05 nM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Galcanezumab (4-16 mg/kg, sc, single dose) exhibits analgesic effect in Monoiodoacetate (HY-W017688)-induced mouse osteoarthritis pain models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ApoE-/- mouse model[2]
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Dosage:30-50 mg/kg
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Administration:sc, 2 doses, 50 mg/kg at the first week, 30 mg/kg at the second week
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Result:Increased lipid deposition in the aortic root, increased the lesion area in the thoracic aorta.
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Animal Model:Monoiodoacetate-induced mouse osteoarthritis pain models[3]
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Dosage:4-16 mg/kg
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Administration:sc, single dose
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Result:Reduced mouse pain behavior.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1X106 A549 cells with Galcanezumab (HY-P99021, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 1578199-75-3
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Appearance Liquid
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Molecular Weight 145.5 kDa
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Color Colorless to light yellow
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SMILES
[Galcanezumab]
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Synonyms
LY 2951742
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biosens Bioelectron
One-step ultra-rapid immunoassay of calcitonin gene-related peptide for migraine diagnosis. [Abstract]2025 Feb 15:270:116980. PMID: 39608279
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Yvette N Lamb. Galcanezumab: First Global Approval. Drugs. 2018 Nov;78(16):1769-1775. [Content Brief]
[2]. Hashikawa-Hobara N, et al., Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice. Sci Rep. 2024 Aug 8;14(1):18377. [Content Brief]
[3]. Benschop RJ, et al., Development of a novel antibody to calcitonin gene-related peptide for the treatment of osteoarthritis-related pain. Osteoarthritis Cartilage. 2014 Apr;22(4):578-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galcanezumab Related Classifications
HY-P99021 Related Classifications
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