2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. Galcanezumab

Galcanezumab  (Synonyms: LY 2951742)

Cat. No.: HY-P99021 Purity: 98.00%
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Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research.

For research use only. We do not sell to patients.

CAS No. : 1578199-75-3

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Based on 1 publication(s) in Google Scholar

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Galcanezumab Related Antibodies

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  • Customer Review

Description

Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Galcanezumab inhibits human or rat CGRP-induced cAMP production in SK-N-MC cell with IC50s of 0.35 nM and 1.05 nM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Galcanezumab Related Antibodies
In Vivo

Galcanezumab (30-50 mg/kg, sc, 2 doses) exacerbates the development of early atherosclerotic lesions in ApoE-/- mice[2].
Galcanezumab (4-16 mg/kg, sc, single dose) exhibits analgesic effect in Monoiodoacetate (HY-W017688)-induced mouse osteoarthritis pain models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE-/- mouse model[2]
Dosage: 30-50 mg/kg
Administration: sc, 2 doses, 50 mg/kg at the first week, 30 mg/kg at the second week
Result: Increased lipid deposition in the aortic root, increased the lesion area in the thoracic aorta.
Animal Model: Monoiodoacetate-induced mouse osteoarthritis pain models[3]
Dosage: 4-16 mg/kg
Administration: sc, single dose
Result: Reduced mouse pain behavior.
Clinical Trial
Molecular Weight

145.5 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Galcanezumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation

Purity: 98.00%

SDS (251 KB)

COA (291 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Galcanezumab Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galcanezumab1578199-75-3LY 2951742LY2951742LY-2951742CGRP ReceptorCalcitonin gene-related peptide receptorhumanized IgG4 monoclonal antibodyCGRP ligandmigrainecluster headachesInhibitorinhibitorinhibit

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