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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
collagen accumulation
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "collagen accumulation" in MCE Product Catalog:
2
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Vevorisertib (ARQ 751) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation. Vevorisertib inhibits tumor cell proliferation through Cyclin D1 and Ki67. Vevorisertib inhibits liver fibrosis through collagen accumulation, alpha-SMA, COL1, and TGF-beta. Vevorisertib reduces total bilirubin. Vevorisertib significantly reduces tumor size in a cirrhotic rat HCC model. Vevorisertib can be used for research on hepatocellular carcinoma .
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2 Cited Publications
Synonyms: ARQ 751 trihydrochloride
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Vevorisertib trihydrochloride (ARQ 751 trihydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation. Vevorisertib trihydrochloride inhibits tumor cell proliferation through Cyclin D1 and Ki67. Vevorisertib trihydrochloride inhibits liver fibrosis through collagen accumulation, alpha-SMA, COL1, and TGF-beta. Vevorisertib trihydrochloride reduces total bilirubin. Vevorisertib trihydrochloride significantly reduces tumor size in a cirrhotic rat HCC model. Vevorisertib trihydrochloride can be used for research on hepatocellular carcinoma .
Cat. No.: HY-P10709
CAS No.: 847058-45-1
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Synonyms: PLA-695
Target:
Phospholipase Reactive Oxygen Species (ROS) Glutathione Peroxidase Ferroptosis Mitochondrial Metabolism
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Giripladib (PLA-695) is a selective cPLA2α inhibitor. Giripladib attenuates CKD serum-induced PUFA accumulation, MDA and ROS levels, restores the GSH/GSSG ratio, and alleviates mitochondria-Ferroptosis-related morphological changes. Giripladib exhibits anti-inflammatory and disease-modifying effects in collagen-induced arthritis. Giripladib can be used in research on chronic kidney disease-associated plaque vulnerability, rheumatoid arthritis, and breast cancer .
Cat. No.: HY-N2441
CAS No.: 74805-90-6
Category:
Ophiopogon japonicus (L. f.) Ker-Gawl. Flavonoids Phenols Polyphenols Plants Liliaceae Extract Disease Research Fields Inflammation/Immunology Other Flavonoids
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Cat. No.: HY-P2483B
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Cat. No.: HY-P2483
CAS No.: 148796-86-5
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Cat. No.: HY-P5081
CAS No.: 1678414-54-4
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Cat. No.: HY-100446
CAS No.: 815619-12-6
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NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes .
Cat. No.: HY-177739
CAS No.: 1590409-23-6
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Antifibrotic agent 2 (Compound 636) is a polycyclic pyridinone derivative with antifibrotic activity. Antifibrotic agent 2 reduces the pathological accumulation of fibrosis-related proteins such as fibronectin and collagen, prevents excessive fibrous connective tissue from depositing in organs or tissues, and reverses or delays the remodeling of tissue fibrosisby regulating the abnormal proliferation and activation of fibroblasts. Antifibrotic agent 2 can be used for research on pulmonary fibrosis .
Cat. No.: HY-P2483A
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Cat. No.: HY-N2441R
CAS No.: 74805-90-6
Cat. No.: HY-184535
CAS No.: 3008320-14-4
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PDIC-DPC is a HMGA1 inhibitor and lung-targeting agent. PDIC-DPC upregulates STING expression and enhances STING-mediated immune signaling. PDIC-DPC inhibits the TGFβ-Smad pathway and activates AMPK. PDIC-DPC forms nanocomplexes with fibrinogen β chain and vitronectin, and achieves lung-specific accumulation by binding to pulmonary endothelial receptors. PDIC-DPC reverses established pulmonary fibrosis, reduces collagen deposition, restores alveolar structure, improves pulmonary function, and inhibits in situ ESCC growth. PDIC-DPC can be used for the research of esophageal squamous cell carcinoma and idiopathic pulmonary fibrosis .
Cat. No.: HY-P5081A
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Cat. No.: HY-182287
Domaines de recherche:
PRDX1-IN-4 is a PRDX1 inhibitor with an IC50 of 122 nM against human targets and high subtype selectivity. PRDX1-IN-4 covalently binds to PRDX1 to promote ROS accumulation. PRDX1-IN-4 inhibits NLRP3 inflammasome activation, blocks hepatic stellate cell activation and reduces collagen deposition. PRDX1-IN-4 induces apoptosis in activated hepatic stellate cells. PRDX1-IN-4 has good safety profile, with no significant body weight loss or hepatotoxicity observed in mice at a dose of 20 mg/kg. PRDX1-IN-4 ameliorates CCl4-induced liver injury and liver fibrosis in mice at a dose of 1 mg/kg. PRDX1-IN-4 can be used for the research of liver fibrosis .
Cat. No.: HY-189274
CAS No.: 3128930-57-1
Target:
HIF/HIF Prolyl-Hydroxylase VEGFR GLUT Reactive Oxygen Species (ROS) Biochemical Assay Reagents
Domaines de recherche:
HIF-1α stabilizer-1 is a HIF-1α stabilizer and iron chelator. HIF-1α stabilizer-1 induces HIF-dependent transcription and upregulates VEGFA and GLUT1 expression without directly binding to PHD1-3. HIF-1α stabilizer-1 inhibits hyperglycemia-induced ROS accumulation. HIF-1α stabilizer-1 promotes cell migration. HIF-1α stabilizer-1 accelerates wound closure and improves tissue remodeling by enhancing neovascularization and collagen deposition. HIF-1α stabilizer-1 lacks antibacterial activity against P. aeruginosa. HIF-1α stabilizer-1 can be used for research on diabetic wounds .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
