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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
coronary contractility
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "coronary contractility" in MCE Product Catalog:
Cat. No.: HY-116326
CAS No.: 712313-33-2
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BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts .
Cat. No.: HY-P10655
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Cat. No.: HY-19066
CAS No.: 115750-37-3
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KW-3407 is an antiarrhythmic agent. KW-3407 can inhibit two-stage (24 and 48 h) coronary ligation-, digitalis- and adrenaline-induced spontaneously occurring arrhythmias with IC50 values of 18.1, 14.4, 18.3 and 21.4 μg/mL. KW-3407 can decrease the sinoatrial rate and contractile force, and increase the coronary blood flow and AV conduction times .
Cat. No.: HY-187768
CAS No.: 90326-85-5
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Nesapidil is an antiarrhythmic agent and calcium channel blocker. Nesapidil slows calcium channel activity, which in turn causes slowing of atrioventricular conduction and sinus heart rate. Nesapidil alters preload, afterload, contractility, and coronary blood flow. Nesapidil can be used in research related to arrhythmia and hypertension .
Cat. No.: HY-187624
CAS No.: 152971-79-4
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CGS-25015 is a mercapto-containing metalloprotease inhibitor that inhibits endothelin-converting enzyme (ECE). CGS-25015 inhibits ECE activity with an IC50 of 2.6 μM in porcine coronary artery smooth muscle preparations, and an IC50 of 18 μM in partially purified porcine aortic endothelial cell ECE preparations. CGS-25015 inhibits endothelin production and the resulting vascular smooth muscle contractile response .
Cat. No.: HY-W745845
CAS No.: 131741-08-7
Synonyms: (rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259
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Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) is a calcium-sensitizing positive inotropic vasodilator compound that enhances myocardial contractility through calcium-dependent binding to cardiac troponin C and selectively inhibits cardiac phosphodiesterase (Phosphodiesterase) III, while inducing coronary and peripheral vasodilation and anti-ischemic effects. Simendan can be used for research on congestive heart failure, acute heart failure, myocardial infarction, myocardial ischemia, and thrombotic diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
