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Cat. No.: HY-W745845

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Simendan

Name: Simendan
Brand: MedChemExpress
SKU: HY-W745845
Availability: PreOrder

(Synonyms: (rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259)

Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) is a calcium-sensitizing positive inotropic vasodilator compound that enhances myocardial contractility through calcium-dependent binding to cardiac troponin C and selectively inhibits cardiac phosphodiesterase (Phosphodiesterase) III, while inducing coronary and peripheral vasodilation and anti-ischemic effects. Simendan can be used for research on congestive heart failure, acute heart failure, myocardial infarction, myocardial ischemia, and thrombotic diseases.

For research use only. We do not sell to patients.

CAS No.: 131741-08-7
Formula: C₁₄H₁₂N₆O
Molecular Weight:280.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Simendan Chemical Structure

CAS No.: 131741-08-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) selectively inhibits cardiac phosphodiesterase III in purified enzyme preparations^[1].
Simendan binds to cardiac troponin C in a calcium-dependent manner in paced papillary muscle preparations, combining positive inotropic effects with enhanced cardiac relaxation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) (2.5 mg/kg; p.o.; free access; 312 days) improves survival in rats with post-myocardial infarction healing, with a mortality rate of 53% at 312 days, representing a 28% risk reduction compared with the control group^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (Male, 300-350 g, healed myocardial infarction via left anterior descending coronary artery ligation)^[3]
Dosage:

2.5 mg/kg
Administration:

p.o.; ad libitum; 312 days
Result:

Reduced mortality rate to 53% at day 312, representing a 28% risk reduction versus control.
Reduced 6-month mortality rate to 19%.
Achieved an infarct size of 43%.
Histological analysis showed an external normal boundary of 11.9 mm, internal normal boundary of 7.6 mm, external infarct boundary of 7.4 mm, internal infarct boundary of 6.2 mm, whole area of 60.7 mm², normal area of 52.4 mm², and infarct area of 8.2 mm².

Chemical Information

CAS No. 131741-08-7
Molecular Weight 280.28
Formula C₁₄H₁₂N₆O
SMILES

N#C/C(C#N)=N/NC1=CC=C(C2=NNC(CC2C)=O)C=C1
Synonyms

(rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lilleberg J, et al. Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers. Clinical pharmacology and therapeutics. 1994 Nov;56(5):554-63.

[2]. Lilleberg JM, et al. Hemodynamic effects of the novel cardiotonic drug simendan: echocardiographic assessment in healthy volunteers. Cardiovascular drugs and therapy. 1994 Apr;8(2):263-9.

[3]. Levijoki J, et al. Improved survival with simendan after experimental myocardial infarction in rats. European journal of pharmacology. 2001 May 11;419(2-3):243-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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