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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
316 Results for "
cytokine/chemokine
" in MedChemExpress (MCE) Product Catalog:
Products (316)
316 Results for "cytokine/chemokine" in MCE Product Catalog:
850
Research Areas:
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
37
37 Cited Publications
Target:
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .
23
Research Areas:
Itacitinib (INCB039110) is an orally active selective inhibitor of JAK1 with an IC50 value of 2 nM for human JAK1. Itacitinib inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .
23
Research Areas:
Itacitinib adipate (INCB039110 adipate) is an orally active JAK1-selective inhibitor. Itacitinib adipate inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib adipate reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib adipate improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib adipate can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .
9
9 Cited Publications
Cat. No.: HY-P7764
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible cytokine A2; MCAF; C-C Motif chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Mouse
Source:
E. coli
9
9 Cited Publications
Cat. No.: HY-P7237
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible cytokine A2; MCAF; C-C Motif chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Activating Factor; Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je; Monocyte Secretory Protein JE; chemokine (C-C Motif) Ligand 2, Isoform CRA_a; SMC-CF; Monocyte Chemoattractant Protein 1; GDCF-2; HSMCR30; Small Inducible cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je); C-C Motif chemokine Ligand 2; Monocyte Chemoattractant Protein-1
Species:
Human
Source:
E. coli
7
7 Cited Publications
Cat. No.: HY-P70450
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL5; T-Cell Specific Protein P288; Prev. D17S136E; C-C Motif chemokine 5; Prev. SCYA5; MGC17164; TCP228; EoCP; SIS-Delta; Small Inducible cytokine A5 (RANTES); RANTES; T-Cell Specific RANTES Protein; SISd; T-Cell-Specific Protein RANTES; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; T Cell-Specific Protein P228; Small Inducible cytokine Subfamily A (Cys-Cys), Member 5; Small-Inducible cytokine A5; Eosinophil Chemotactic cytokine; C-C Motif chemokine; chemokine (C-C Motif) Ligand 5; C-C Motif chemokine Ligand 5; Beta-chemokine RANTES
Species:
Human
Source:
E. coli
7
7 Cited Publications
Cat. No.: HY-P7224
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic Factor I; MDNCF; Tumor Necrosis Factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic Factor; GCP-1; Interleukin 8; Monocyte-Derived Neutrophil Chemotactic Factor; Interleukin-8; Monocyte-Derived Neutrophil-Activating Peptide; Emoctakin; Granulocyte Chemotactic Protein 1; AMCF-I; chemokine (C-X-C Motif) Ligand 8; B-ENAP; SCYB8; TSG-1; LYNAP; 3-10C; LUCT; K60; LECT; Small Inducible cytokine Subfamily B, Member 8; IL-8; Beta-Thromboglobulin-Like Protein; GCP1; Neutrophil-Activating Protein 1; NAP1; C-X-C Motif chemokine 8; NAF; C-X-C Motif chemokine; Beta Endothelial Cell-Derived Neutrophil Activating Peptide; Protein 3-10C; C-X-C Motif chemokine Ligand 8; Lymphocyte Derived Neutrophil Activating Peptide
Species:
Human
Source:
E. coli
5
5 Cited Publications
Cat. No.: HY-P7243
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL7; Monocyte Chemotactic Protein 3; Prev. SCYA6; FIC; Prev. SCYA7; Small Inducible cytokine A7 (Monocyte Chemotactic Protein 3); MCP-3; chemokine (C-C Motif) Ligand 7; NC28; Small-Inducible cytokine A7; MCP3; C-C Motif chemokine 7; Monocyte Chemoattract
Species:
Mouse
Source:
E. coli
5
5 Cited Publications
Cat. No.: HY-P7226
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL10; Small Inducible cytokine Subfamily B (Cys-X-Cys), Member 10; Prev. SCYB10; Small-Inducible cytokine B10; Prev. INP10; C-X-C Motif chemokine 10; IP-10; Protein 10 From Interferon (Gamma)-Induced Cell Line; GIP-10; Interferon-Inducible cytokine IP-1
Species:
Human
Source:
E. coli
4
4 Cited Publications
Cat. No.: HY-P7180
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CX3CL1; NTN; Prev. SCYD1; CX3C Membrane-Anchored chemokine; chemokine (C-X3-C Motif) Ligand 1; Small-Inducible cytokine D1; Fractalkine; C-X3-C Motif chemokine 1; Neurotactin; NTT; C3Xkine; Small Inducible cytokine Subfamily D (Cys-X3-Cys), Member-1; ABCD
Species:
Human
Source:
E. coli
4
4 Cited Publications
Cat. No.: HY-P7255
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL3; Tonsillar Lymphocyte LD78 Alpha Protein; Prev. SCYA3; C-C Motif chemokine 3; MIP-1-Alpha; PAT 464.1; G0S19-1; SIS-Beta; LD78ALPHA; MIP1A; LD78; Macrophage Inflammatory Protein 1 Alpha; SCI; chemokine (C-C Motif) Ligand 3; Small Inducible cytokine A3
Species:
Mouse
Source:
HEK293
4
4 Cited Publications
Cat. No.: HY-P7257
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL4; Act-2; Prev. SCYA4; MIP1B; Prev. LAG1; HC21; MIP-1-Beta; Monocyte Adherence-Induced Protein 5 Alpha; AT744.1; chemokine C-C Motif Ligand 4; Small Inducible cytokine A4 (Homologous To Mouse Mip-1b); Small-Inducible cytokine A4; Macrophage Inflammator
Species:
Human
Source:
E. coli
3
3
3 Cited Publications
Cat. No.: HY-P7239
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL8; chemokine (C-C Motif) Ligand 8; Prev. SCYA8; Small-Inducible cytokine A8; MCP-2; C-C Motif chemokine 8; HC14; SCYA10; Small Inducible cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2); MCP2; Monocyte Chemoattractant Protein 2
Species:
Mouse
Source:
E. coli
3
3
3 Cited Publications
Target:
Research Areas:
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .
3
3 Cited Publications
Synonyms: Bisperoxovanadium(phen) trihydrate
Target:
Research Areas:
BpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. BpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). BpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .
3
PXS-4728A is an orally active, selective VAP-1/SSAO inhibitor with an IC50 of 5 nM and a Ki of 175 nM. PXS-4728A inhibits the expression of MMP-9. It reduces cell rolling, adhesion and migration, decreases cell infiltration levels, pro-inflammatory cytokines, chemokines and collagen deposition, and improves pulmonary function. PXS-4728A reduces the formation and progression of atherosclerotic plaques, and decreases blood lipid and blood glucose levels as well as body weight gain. PXS-4728A can be used in research related to chronic obstructive pulmonary disease, cystic fibrosis, acute pulmonary inflammation, acute lung injury, bronchiolitis obliterans syndrome, rhinovirus-exacerbated asthma, sepsis, Klebsiella pneumoniae pulmonary infection and atherosclerosis .
3
3 Cited Publications
Synonyms: Halite, meets analytical specification of Ph. Eur. BP USP
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
