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Results for "

disease angina

" in MedChemExpress (MCE) Product Catalog:

標的別:	5-HT Receptor (1) Adrenergic Receptor (12) Antibiotic (1) Apoptosis (13) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Cadherin (1) Calcium Channel (8) Carnitine Palmitoyltransferase (CPT) (3) Caspase (1) Cytochrome P450 (1) Dopamine Receptor (1) Drug Derivative (1) Drug Isomer (1) Endogenous Metabolite (2) Environmental Pollutants (1) Fungal (2) Guanylate Cyclase (1) iGluR (1) Isotope-Labeled Compounds (1) LPL Receptor (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (3) NO Synthase (1) Phospholipase (1) Potassium Channel (3) Prostaglandin Receptor (1) Proteolytic Enzyme (1) Reference Standards (6) β-catenin (1)
研究分野別:	Cancer (14) Cardiovascular Disease (35) Endocrinology (7) Infection (7) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)

標的別:

5-HT Receptor (1)

Adrenergic Receptor (12)

Antibiotic (1)

Apoptosis (13)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (1)

Cadherin (1)

Calcium Channel (8)

Carnitine Palmitoyltransferase (CPT) (3)

Caspase (1)

Cytochrome P450 (1)

Dopamine Receptor (1)

Drug Derivative (1)

Drug Isomer (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Fungal (2)

Guanylate Cyclase (1)

iGluR (1)

Isotope-Labeled Compounds (1)

LPL Receptor (1)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (3)

NO Synthase (1)

Phospholipase (1)

Potassium Channel (3)

Prostaglandin Receptor (1)

Proteolytic Enzyme (1)

Reference Standards (6)

β-catenin (1)

研究分野別:

Cancer (14)

Cardiovascular Disease (35)

Endocrinology (7)

Infection (7)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (3)

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スクリーニングライブラリ

天然物

同位体標識化合物

製品番号	製品名	Target	研究分野	構造式

HY-B1334A

Perhexiline maleate 5+ Cited Publications	Carnitine Palmitoyltransferase (CPT) Mitochondrial Metabolism Apoptosis	Cardiovascular Disease Cancer
Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina .

HY-17503

Metoprolol Maximum Cited Publications 15 Publications Verification	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17583

Griseofulvin 1 Publications Verification	Environmental Pollutants Antibiotic Apoptosis Fungal Endogenous Metabolite Bcl-2 Family Caspase Microtubule/Tubulin	Infection Cardiovascular Disease Cancer
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome .

HY-17503B

Metoprolol tartrate Maximum Cited Publications 15 Publications Verification	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-B1334

Perhexiline 5+ Cited Publications	Carnitine Palmitoyltransferase (CPT) Mitochondrial Metabolism Apoptosis	Cardiovascular Disease Cancer
Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina .

HY-B0642

Isosorbide mononitrate 5 Publications Verification Isosorbide-5-mononitrate	Autophagy Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-17503A

Metoprolol succinate Maximum Cited Publications 15 Publications Verification	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-B0341

Nicorandil 1 Publications Verification SG-75	Potassium Channel	Cardiovascular Disease
Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K ⁺ channels and cardiac ATP-sensitive K ⁺ channels (K_ATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-B1486

Oxprenolol hydrochloride 1 Publications Verification Ba 39089	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-N6065

Praeruptorin A 3 Publications Verification (+)-Praeruptorin A	Calcium Channel Drug Isomer Cytochrome P450 iGluR Apoptosis	Cardiovascular Disease Neurological Disease
Praeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension .

HY-17503R

Metoprolol (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (Standard) is the analytical standard of Metoprolol. This product is intended for research and analytical applications. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503AR

Metoprolol succinate (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol (succinate) (Standard) is the analytical standard of Metoprolol (succinate). This product is intended for research and analytical applications. Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-B0341S

Nicorandil-d4	Isotope-Labeled Compounds Potassium Channel	Cardiovascular Disease
Nicorandil-d₄ (SG-75-d₄) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-121045

Bunitrolol KO 1366	Adrenergic Receptor	Cardiovascular Disease
Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α₁-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research .

HY-W040176

N-PTyrosine PA ammonium N-Palmitoyl-tyrosine phosphoric acid ammonium	LPL Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke) .

HY-125093

SL-870495	Calcium Channel	Cardiovascular Disease
SL-870495 is a calcium antagonist targeting L-type calcium channels. SL-870495 is promising for research of cardiovascular diseases such as hypertension and angina pectoris .

HY-131896

FR144420 NOR4	NO Synthase	Cardiovascular Disease
FR144420 (NOR4) is an orally active nitric oxide (NO)-releasing agent with vasodilatory and antiplatelet effects. FR144420 induces cGMP-mediated vasodilation and inhibits platelet aggregation. FR144420 is promising for research of cardiovascular diseases, particularly angina pectoris and coronary artery spasm .

HY-105866

Wy 27569	Calcium Channel Prostaglandin Receptor	Cardiovascular Disease
Wy 27569 is an orally active vascular selective calcium channel blocker that can effectively lower blood pressure. Wy 27569 is a thromboxane synthase inhibitor that can reshape prostaglandin balance, reduce pro thrombotic TXA2, and increase anti thrombotic PGI2. Wy 27569 can be used for research on cardiovascular diseases such as hypertension and angina .

HY-17503BR

Metoprolol tartrate (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (tartrate) (Standard) is the analytical standard of Metoprolol (tartrate). This product is intended for research and analytical applications. Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-101390D

(R)-Niguldipine	Calcium Channel	Cardiovascular Disease
(R)-Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID₅₀ of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (K_i of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED₃₀ of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .

HY-106239

Fostedil KB 944	Calcium Channel	Cardiovascular Disease
Fostedil (KB 944) is a calcium antagonist that can be used in the research of heart diseases such as angina pectoris .

HY-B0341R

Nicorandil (Standard) SG-75 (Standard)	Reference Standards Potassium Channel	Cardiovascular Disease
Nicorandil (Standard) is the analytical standard of Nicorandil. This product is intended for research and analytical applications. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K ⁺ channels and cardiac ATP-sensitive K ⁺ channels (K_ATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-177477

2,5-Epidithia-3,6-dioxopiperazine	Drug Derivative Cadherin β-catenin	Cardiovascular Disease Cancer
2,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP). 2,5-Epidithia-3,6-dioxopiperazine improves intracellular penetration and restores the activity of 2-Cys-Prx (especially Peroxiredoxin II (PrxII)) of form simulation in cells. 2,5-Epidithia-3,6-dioxopiperazine inhibits PDGF-induced proliferation and migration in vascular smooth muscle cells while promoting these actions in endothelial cells with VEGF induction. 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation and migration and lung metastasis of melanoma cells. 2,5-Epidithia-3,6-dioxopiperazine can be used for vascular diseases such as hypertension, angina pectoris and myocardial infarction research .

HY-142698

SGC agonist 2	Guanylate Cyclase	Cardiovascular Disease
SGC agonist 2 is a potent agonist of soluble guanylate cyclase (SGC). Soluble guanylate cyclase is a key signal transduction enzyme in the NO-sGC-cGMP signaling pathway. SGC agonist 2 has the potential for the research of cardiovascular disease (heart failure, pulmonary hypertension, angina, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis) (extracted from patent WO2021219088A1, compound 031) .

HY-106904

Nexopamil	Calcium Channel 5-HT Receptor Dopamine Receptor	Cardiovascular Disease
Nexopamil is a calcium antagonist of Ca ²⁺ channel, 5HT₂, 5HT_1A, 5HT_1C and dopamine D₂ receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease .

HY-B1334AR

Perhexiline maleate (Standard)	Carnitine Palmitoyltransferase (CPT) Mitochondrial Metabolism Apoptosis Reference Standards	Cardiovascular Disease Cancer
Perhexiline (maleate) (Standard) is the analytical standard of Perhexiline (maleate). This product is intended for research and analytical applications. Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina .

HY-B1486R

Oxprenolol hydrochloride (Standard) Ba 39089 (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Oxprenolol (hydrochloride) (Standard) is the analytical standard of Oxprenolol (hydrochloride). This product is intended for research and analytical applications. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-17503C

Metoprolol fumarate CGP 2175C; Lopressor OROS	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-101390A

(-)-Niguldipine hydrochloride (R)-Niguldipine hydrochloride	Calcium Channel	Cardiovascular Disease
(-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID₅₀ of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (K_i of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED₃₀ of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .

HY-160637

Lp-PLA2-IN-17	Phospholipase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Lp-PLA2-IN-17 (Compound 39) is an inhibitor of Lp-PLA₂. Lp-PLA2-IN-17 can be used to study disorders involving the hydrolysis of oxidized lipids into two inflammatory substances with the participation of Lp-PLA₂ .

HY-108291

Propatyl nitrate	Others	Cardiovascular Disease
Propatyl nitrate is a coronary vasodilator. Propatyl nitrate is also a nitric oxide donor. Propatyl nitrate can be used in research on cardiovascular and cerebrovascular diseases such as acute angina attacks .

HY-106468

Bornaprolol FM-24	Adrenergic Receptor	Cardiovascular Disease
Bornaprolol (FM-24) is a β-adrenoceptor antagonist. Bornaprolol significantly depresses plasma levels of luteinizing hormone (LH) in orchidectomized rat models. Bornaprolol can be used for cardiovascular diseases like hypertension and angina pectoris research .

HY-106458

Niludipine Bay a 7168	Calcium Channel	Cardiovascular Disease
Niludipine (Bay a 7168) is an orally active calcium channel blocker and vasodilator with antihypertensive effects. Niludipine can improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in rats. Niludipine can reduce left ventricular systolic and diastolic loads during pacing-induced angina pectoris. Niludipine can be used in the research of cardiovascular diseases such as coronary heart disease and myocardial ischemia .

HY-E71367

Bromelain (USP)	Proteolytic Enzyme Bacterial Fungal	Cardiovascular Disease Infection Inflammation/Immunology Cancer
Bromelain USP is an orally active proteolytic agent. Bromelain USP converts plasminogen to plasmin to support fibrinolysis, cleaves CD44 adhesion molecules from cell surfaces, and diminishes uPAR expression and uPA activity. Bromelain USP can inhibit the activity of a variety of fungi and bacteria. Bromelain USP can be used for the research of angina pectoris, atherosclerotic disease, fungal infections, bacterial infections, chronic inflammatory bowel disease, and cancer .

HY-116957

Bunitrolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α₁-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research .

製品番号	製品名

HY-L238

Mongolian Medicine Compound Library	2,380 compounds
Mongolian medicine refers to drugs used for disease prevention and treatment under the guidance of Mongolian medical theory. Originating from the vast grasslands and desert regions of northern China, Mongolian medicine developed under specific natural conditions and a nomadic lifestyle, forming a unique theoretical system and treatment methods. It emphasizes the balance between the human body and the natural environment and has demonstrated distinct efficacy in treating digestive system diseases, rheumatism, skin diseases, and various chronic conditions. For example, Mongolian medicine often uses Chinese red date for palpitations and angina pectoris, sea buckthorn to relieve coughs, reduce phlegm, promote blood circulation, and remove blood stasis, and scabious to clear lung heat and treat liver heat diseases. The application of these characteristic Mongolian medicines embodies the profound wisdom of Mongolian medical practice. With the advancement of modern technology, research on Mongolian medicine continues to deepen. Systematic studies on the chemical composition and pharmacological effects of Mongolian medicines can provide new ideas and methods for modern drug development. MCE has collected 2,380 characteristic natural products derived from Mongolian medicines, with 400+ plant sources of Mongolian medicine.

Mongolian Medicine Compound Library

2,380 compounds

Mongolian medicine refers to drugs used for disease prevention and treatment under the guidance of Mongolian medical theory. Originating from the vast grasslands and desert regions of northern China, Mongolian medicine developed under specific natural conditions and a nomadic lifestyle, forming a unique theoretical system and treatment methods. It emphasizes the balance between the human body and the natural environment and has demonstrated distinct efficacy in treating digestive system diseases, rheumatism, skin diseases, and various chronic conditions. For example, Mongolian medicine often uses Chinese red date for palpitations and angina pectoris, sea buckthorn to relieve coughs, reduce phlegm, promote blood circulation, and remove blood stasis, and scabious to clear lung heat and treat liver heat diseases. The application of these characteristic Mongolian medicines embodies the profound wisdom of Mongolian medical practice.

With the advancement of modern technology, research on Mongolian medicine continues to deepen. Systematic studies on the chemical composition and pharmacological effects of Mongolian medicines can provide new ideas and methods for modern drug development.

MCE has collected 2,380 characteristic natural products derived from Mongolian medicines, with 400+ plant sources of Mongolian medicine.

HY-L117

Calcium Channel Blocker Library	217 compounds
Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat. MCE supplies a unique collection of 217 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Calcium Channel Blocker Library

217 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 217 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

製品番号	製品名	Category	Target	構造式

HY-17503

Metoprolol Maximum Cited Publications 15 Publications Verification	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor Apoptosis
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17583

Griseofulvin 1 Publications Verification	Structural Classification 天然物 Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	Environmental Pollutants Antibiotic Apoptosis Fungal Endogenous Metabolite Bcl-2 Family Caspase Microtubule/Tubulin
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome .

HY-B0642

Isosorbide mononitrate 5 Publications Verification Isosorbide-5-mononitrate	Cardiovascular Disease Structural Classification 天然物 Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Autophagy Endogenous Metabolite Apoptosis
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-N6065

Praeruptorin A 3 Publications Verification (+)-Praeruptorin A	Structural Classification Classification of Application Fields Coumarins Salvia hypargeia Fisch. & C.A.Mey. Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Calcium Channel Drug Isomer Cytochrome P450 iGluR Apoptosis
Praeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension .

製品番号	製品名	構造式

HY-B0341S

Nicorandil-d4
Nicorandil-d₄ (SG-75-d₄) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

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