Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
epithelial melanoma
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "epithelial melanoma" in MCE Product Catalog:
79
79 Publications Verification
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Category:
Apocynaceae Alkaloids Anti-aging Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don
Target:
79
79 Publications Verification
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Category:
Apocynaceae Alkaloids Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don
Target:
1
Target:
1
1 Cited Publications
Cat. No.: HY-N0819
CAS No.: 89412-79-3
1
Category:
Cardiovascular Disease Neurological Disease Plants Infection Alkaloids Capsicum annuum L. Other Alkaloids Solanaceae Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-P5423
CAS No.: 107658-43-5
Target:
Research Areas:
TD1092 is a pan-inhibitor of apoptosis protein (IAP) PROTAC degrader that targets cIAP1, cIAP2, and XIAP for degradation. TD1092 induces cell apoptosis by activating caspase. TD1092 inhibits the NF-κB signaling pathway induced by TNFα. TD1092 suppresses TNFα-induced epithelial-mesenchymal transition, cancer cell migration, and invasion. TD1092 is suitable for research on breast cancer, ovarian cancer, melanoma, and inflammation-related diseases .
Cat. No.: HY-N0488S
CAS No.: 1246817-10-6
Synonyms: Leurocristine-d3 sulfate; NSC-67574-d3 sulfate; 22-Oxovincaleukoblastine-d3 sulfate
Cat. No.: HY-153858
CAS No.: 2470433-36-2
Research Areas:
PHI-501 is a dual inhibitor targeting RAF/DDR. PHI-501 exhibits significant anti-proliferative effects in melanoma cell lines and significantly inhibits the colony formation of drug-resistant cells. PHI-501 strongly inhibits ERK and AKT phosphorylation. PHI-501 downregulates the gene sets in drug-resistant cells of TNFA-NFKB, IL6-JAK-STAT3, and KRAS signaling pathways as well as the epithelial-mesenchymal transition (EMT) signaling pathways. PHI-501 demonstrates significant anti-tumor effects in the SK-MEL3DR xenograft model. PHI-501 can be used for research on the problem of drug resistance in melanoma .
Cat. No.: HY-W011209R
CAS No.: 7724-76-7
Synonyms: Riboprine (Standard)
Category:
Cat. No.: HY-125535
CAS No.: 1290069-19-0
Research Areas:
OSU-53 is an orally active AMPK activator and mTOR inhibitor, with an IC50 of 0.3 μM for AMPK, an EC50 of 2-5 μM for AMPK, and an IC50 of 8.23 μM for mTOR. OSU-53 inhibits the Akt signaling pathway, directly activates AMPK by binding to its autoinhibitory domain, reduces IKKβ-mediated phosphorylation of Foxo3a, blocks Akt-mediated phosphorylation of MDM2, and promotes the nuclear localization and stabilization of Foxo3a, while directly inhibiting mTOR. OSU-53 inhibits epithelial-mesenchymal transition (EMT), induces epithelial phenotype, suppresses invasion and metastasis, induces autophagy, inhibits the activation of ERK and Akt, reduces the secretion of nitric oxide and proinflammatory cytokines, and inhibits the migration of MDSC; at high doses, it induces MDSC apoptosis, attenuates the immunosuppressive effect of MDSC, reduces MDSC levels, and blocks incision-induced mechanical hyperalgesia. OSU-53 can be used in studies related to breast cancer, prostate cancer, thyroid cancer, melanoma and postoperative pain .
Cat. No.: HY-N0488S2
Synonyms: Leurocristine-d6 sulfate; NSC-67574-d6 sulfate; 22-Oxovincaleukoblastine-d6 sulfate
Cat. No.: HY-N0488S1
CAS No.: 1217854-24-4
Synonyms: Leurocristine-d3-1 sulfate; NSC-67574-d3-1 sulfate; 22-Oxovincaleukoblastine-d3-1 sulfate
Synonyms: Leurocristine sulfate (Standard); NSC-67574 sulfate (Standard); 22-Oxovincaleukoblastine sulfate (Standard)
Cat. No.: HY-160218
CAS No.: 2848684-50-2
HPK1-IN-42 (compound 185) ia a HPK1 inhibitor with the IC50 50 of 0.24 nM .
Cat. No.: HY-N0819R
CAS No.: 89412-79-3
Category:
Cat. No.: HY-126562R
CAS No.: 5950-12-9
Cat. No.: HY-117612
CAS No.: 1344698-28-7
Target:
Research Areas:
KS-99 is a dual inhibitor with both tubulin polymerization inhibitory activity and Akt pathway inhibitory activity. KS-99 inhibits cancer cell proliferation and induces cancer cell apoptosis. KS-99 can be used in research related to colorectal cancer, breast cancer, lung epithelial cancer and melanoma .
Cat. No.: HY-N19312
CAS No.: 28164-57-0
Category:
Quinones Ebenaceae Phenols Polyphenols Benzene Quinones Plants
Cat. No.: HY-P991959
Target:
Research Areas:
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
