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Results for "

ganglioside

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Apoptosis (9) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (30) Caspase (3) Complement System (1) Drug Derivative (4) E-Selectin (1) EGFR (3) Endogenous Metabolite (11) ERK (5) FAK (1) Ferroptosis (1) Fluorescent Dye (1) Glucosylceramide Synthase (GCS) (2) Glycosidase (8) iGluR (2) Insulin Receptor (2) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (9) Mitochondrial Metabolism (3) mRNA (1) mTOR (2) p38 MAPK (1) Parasite (1) Pyk2 (1) Src (1) TET Protein (2) Toll-like Receptor (TLR) (2) Trk Receptor (3) VEGFR (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (1) Infection (9) Inflammation/Immunology (10) Metabolic Disease (22) Neurological Disease (26)
Oligonucleotides:	mRNA (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9914

Eculizumab 4 Publications Verification Anti-Human C5, Humanized Antibody; h5G1.1	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-N10546

Ganglioside GM1	iGluR Trk Receptor ERK Apoptosis Autophagy	Neurological Disease
Ganglioside GM1 is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and ERK1/2, and inhibiting oxidative stress and cell apoptosis and autophagy. Ganglioside GM1 can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-114456

Ganglioside GM3 2 Publications Verification	Insulin Receptor	Metabolic Disease
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-131686

Ganglioside GT1b (bovine) ammonium	Akt mTOR EGFR ERK	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease .

HY-165740

Ganglioside GD2 Disialoganglioside GD2	Apoptosis	Cancer
Ganglioside GD2 (Disialoganglioside GD2) is a tumor-associated antigen. Ganglioside GD2 shows limited expression in normal tissues but is overexpressed in multiple tumor types, and thus can serve as a target in cancer. Ganglioside GD2 is associated with tumor development and malignant phenotypes, and its mechanism of action relies on enhancing cell proliferation, motility, migration, adhesion and invasion, with specific effects depending on the tumor type .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Endogenous Metabolite	Metabolic Disease Cancer
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Biochemical Assay Reagents	Others
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

HY-148385

Ganglioside GM2	Endogenous Metabolite Integrin FAK Src ERK p38 MAPK	Neurological Disease Cancer
Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-P11094

Tet1-Cys peptide	TET Protein	Neurological Disease
Tet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor GT1b, possessing neuronal targeting capabilities. The Tet1-Cys peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery .

HY-W747597

Ganglioside GD1b Disodium Salt (Bovine Brain) Disialoganglioside GD1b; ganglioside C1; ganglioside G2	Endogenous Metabolite	Cancer
Ganglioside GD1b Disodium Salt (Bovine Brain) (Disialoganglioside GD1b; Ganglioside C1) is an acidic glycosphingolipid containing two sialic acid residues linked to an internal galactose unit. Ganglioside GD1b Disodium Salt tightly packs with cholesterol to form lipid microdomains that modulate intracellular and intercellular signaling events. Concentrations of Ganglioside GD1b Disodium Salt (Bovine Brain) in the human brain increase with age and are positively correlated with pilocytic astrocytoma tumor grade. Ganglioside GD1b Disodium Salt has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.

HY-N7390

Cholesterol glucuronide	Endogenous Metabolite	Metabolic Disease
Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

HY-N10534

Lewis X trisaccharide Lewis X	Parasite	Infection Inflammation/Immunology Cancer
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-E70043

Ganglioside sialidase (AuSialidase S) Sialidase isoenzyme S; AuSialidase S	Endogenous Metabolite	Metabolic Disease
Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .

HY-W747599

Ganglioside GQ1b (bovine) sodium Tetrasialoganglioside GQ1b sodium	Pyk2 Endogenous Metabolite	Neurological Disease
Ganglioside GQ1b (bovine) sodium promotes neurite outgrowth during early neuronal differentiation. Ganglioside GQ1b (bovine) sodium controls the neuronal differentiation process in mESCs .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research .

HY-P10529

Ganglioside GM1-binding peptide p3	Trk Receptor	Infection
Ganglioside GM1-binding peptide p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptide p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 can be used to study the interaction between GM1 and its ligands .

HY-116392F

D-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease Cancer
D-threo-PDMP hydrochloride is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP hydrochloride inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP hydrochloride inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP hydrochloride can be used to study diseases related to targeted glycosphingolipid metabolism .

HY-131139A

Ganglioside GD3 diammonium	Apoptosis	Neurological Disease Cancer
Ganglioside GD3 diammonium is an acidic glycosphingolipid. Ganglioside GD3 diammonium inhibits the proliferation of cancer cells, affects the opening of the mitochondrial permeability transition pore (PTPC), induces apoptosis and activates caspase family. Ganglioside GD3 diammonium can be used in research about cancer and neurodegenerative diseases .

HY-141569

Ganglioside GD1a	Toll-like Receptor (TLR)	Inflammation/Immunology
Ganglioside GD1a modulates toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts. Ganglioside GD1a significantly reduces the effect of LPS on the decrease of cell survival and on stimulation of reactive oxygen species production .

HY-N10546A

Ganglioside GM1 (bovine) ammonium	iGluR Trk Receptor ERK Apoptosis Autophagy	Neurological Disease
Ganglioside GM1 (bovine) ammonium is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 (bovine) ammonium exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and ERK1/2, and inhibiting oxidative stress and cell apoptosis and autophagy. Ganglioside GM1 (bovine) ammonium can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-157343A

*GD3 Ganglioside* sodium**	Apoptosis Mitochondrial Metabolism Caspase	Neurological Disease Cancer
GD3 Ganglioside sodium is an Apoptosis inducer and biomarker for mouse neural stem cells. GD3 Ganglioside sodium expresses in neural stem cells and the subventricular zone of the adult mouse brain. GD3 Ganglioside sodium targets the mitochondrial permeability transition pore complex, induces pore opening, dissipates mitochondrial transmembrane potential, triggers Mitochondrial swelling, releases pro-apoptotic factors, and activates Caspase-9. GD3 Ganglioside sodium is applicable to research related to glioblastoma .

HY-157343B

*GD3 Ganglioside* ammonium**	Apoptosis Mitochondrial Metabolism Caspase	Neurological Disease Cancer
GD3 Ganglioside ammonium is an Apoptosis inducer and biomarker for mouse neural stem cells. GD3 Ganglioside ammonium expresses in neural stem cells and the subventricular zone of the adult mouse brain. GD3 Ganglioside ammonium targets the mitochondrial permeability transition pore complex, induces pore opening, dissipates mitochondrial transmembrane potential, triggers Mitochondrial swelling, releases pro-apoptotic factors, and activates Caspase-9. GD3 Ganglioside ammonium is applicable to research related to glioblastoma .

HY-157343

GD3 Ganglioside	Apoptosis Mitochondrial Metabolism Caspase	Neurological Disease Cancer
GD3 Ganglioside is an Apoptosis inducer and a biomarker for mouse neural stem cells. GD3 Ganglioside expresses in neural stem cells and the subventricular zone of the adult mouse brain. GD3 Ganglioside targets the mitochondrial permeability transition pore complex, induces pore opening, dissipates mitochondrial transmembrane potential, triggers Mitochondrial swelling, releases pro-apoptotic factors, and activates Caspase-9. GD3 Ganglioside is applicable to research related to glioblastoma .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Others	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-131686A

Ganglioside GT1b (porcine) ammonium	Akt mTOR EGFR ERK	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (porcine) ammonium is a member of the ganglioside family. Ganglioside GT1b (porcine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (porcine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (porcine) ammonium enhances porcine oocyte maturation and induces activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (porcine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (porcine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease .

HY-W854385

Sialyl Lewis A SLeA	Biochemical Assay Reagents E-Selectin	Cancer
Sialyl Lewis A (SLeA) is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer .

HY-131139

Ganglioside GD3 disodium salt	Apoptosis	Neurological Disease Cancer
Ganglioside GD3 disodium salt is an acidic glycosphingolipid. Ganglioside GD3 disodium salt inhibits the proliferation of cancer cells, affects the opening of the mitochondrial permeability transition pore (PTPC), induces apoptosis and activates caspase family. Ganglioside GD3 disodium salt can be used in research about cancer and neurodegenerative diseases .

HY-W714151

Ganglioside ga1 Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b	Biochemical Assay Reagents	Metabolic Disease
Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.

HY-114456AS

Ganglioside GM3-d5 Bovine Milk ammonium salt	Isotope-Labeled Compounds	Others
Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

HY-N16333

C18:0 GD2 Ceramide (d18:1/18:0)	Biochemical Assay Reagents	Others
C18:0 GD2 Ceramide (d18:1/18:0) is a ganglioside .

HY-N15820

C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0)	Biochemical Assay Reagents	Others
C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0) is a ganglioside.

HY-114456S

Ganglioside GM3-d7	Isotope-Labeled Compounds Others	Metabolic Disease
Ganglioside GM3-d₇ is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-166325A

Ganglioside GD3-d3 ammonium	Biochemical Assay Reagents	Metabolic Disease
Ganglioside GD3-d₃ ammonium is the deuterium labeled Ganglioside GD3 ammonium. Ganglioside GD3 ammonium is an ester product.

HY-152002S

Ganglioside GM3-d3 ammonium	Isotope-Labeled Compounds	Others
Ganglioside GM3-d3 ammonium is a deuterated labeled Ganglioside GM3 ammonium .

HY-171936

Ganglioside GM1 ammonium GM1 (d18:1/C18:0) ammonium; C18 ganglioside GM1 (d18:1/18:0) ammonium	Endogenous Metabolite	Neurological Disease
Ganglioside GM1 (ammonium) is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 (ammonium) is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 (ammonium) exhibits anti-inflammatory property. Ganglioside GM1 (ammonium) has a well-balanced amphiphilic behavior. Ganglioside GM1 (ammonium) can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 (ammonium) can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 (ammonium) can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 (ammonium) can be studied in neurodegenerative diseases such as Alzheimer’s disease .

HY-152003S

Ganglioside GM2-d3 ammonium	Isotope-Labeled Compounds	Others
Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-146876S

*C18:0 GM1 Ganglioside-d5 ammonium*	Isotope-Labeled Compounds	Others
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-165665S

*C16 Ganglioside* GM3-d9 ammonium salt**	Isotope-Labeled Compounds	Others
C16 Ganglioside GM3-d₉ (ammonium salt) is deuterium labeled C16 Ganglioside GM3 (ammonium salt) .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents	Others
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-165160

*N-Glycolyl-ganglioside* GM3 ammonium** GM3-Neugc ammonium; NeuGc-GM3 ammonium	Biochemical Assay Reagents	Others
N-Glycolyl-ganglioside GM3 ammonium is a biochemical reagent.

HY-171942A

*C24:1 Ganglioside* GM2 (d18:1/24:1) ammonium** C24:1-GM2 ammonium	Endogenous Metabolite	Neurological Disease
C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium) is an endogenous monosialylated ganglioside. C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium) is a self-lipid that can bind to CD1d in HEK293T cells .

HY-P99743

Mitumomab	Biochemical Assay Reagents	Cancer
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .

HY-W127324

Ganglioside GM3 (phyto-type) NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)	Biochemical Assay Reagents	Others
Ganglioside GM3 (phyto-type) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-171443

Lyso-Monosialoganglioside GM3 Lyso-GM3	EGFR Drug Derivative	Cancer
Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analogue of Ganglioside GM3 (HY-114456) with antitumor activities. Lyso-Monosialoganglioside inhibits EGF-induced increases in EGFR kinase activity in A431 epithelial cancer cells .

HY-165676AS

*C16 Ganglioside* GM2-d9 (d18:1/16:0-d9) ammonium salt** C16 GM2-dN_{; N-CD}N_{-Palmitoyl-GM2, N-Hexadecaoyl-d}N_{(13,13,14,14,15,15,16,16,16)-Moosialogaglioside GM2; N-Palmitoyl Moosialogaglioside GM2-d₉}	Isotope-Labeled Compounds	Others
C16 Ganglioside GM2-d₉ (d₁₈:1/16:0-d₉) (C16 GM2-d₉) ammonium saltis deuterium labeled C16 Ganglioside GM2 (d18:1/16:0) (ammonium salt) .

HY-N16004

C18:0 B Antigen ceramide (d18:1/18:0)	Biochemical Assay Reagents	Others
C18:0 B Antigen ceramide (d18:1/18:0) is a ganglioside.

HY-N15798

C18:0 Lc3 Ceramide (d18:1/18:0)	Biochemical Assay Reagents	Others
C18:0 Lc3 Ceramide (d18:1/18:0) is a ganglioside.

HY-N16029

C18:0 Fuc-GM1 Ceramide (d18:1/18:0)	Biochemical Assay Reagents	Cancer
C18:0 Fuc-GM1 Ceramide (d18:1/18:0) is a ganglioside that can be used to synthesize lipid nanoparticles for drug delivery .

Cat. No.	Product Name	Type

HY-173643

*C6 Biotin ganglioside* gm3 (d18:1/6:0) ammonium** Biotin-C6:0-gm3 ammonium; N-Hexanoyl-biotin-monosialoganglioside gm3 ammonium	Fluorescent Dyes
C6 Biotin ganglioside gm3 (d18:1/6:0) (Biotin-C6:0-gm3) ammonium is a derivative of ganglioside GM3. C6 Biotin ganglioside gm3 (d18:1/6:0) ammonium can be used to detect or immobilize ganglioside GM3 through interaction with the biotin ligand .

HY-175074

*C3 BODIPY Ganglioside* GM1 (d18:1/3:0) ammonium**	Fluorescent Dyes
C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium is a fluorescently labeled GM1 ganglioside probe. C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium can be used as a probe in biological experiments .

Cat. No.	Product Name	Type

HY-P3394

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Biochemical Assay Reagents

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

HY-W127461

Ganglioside GM2, Asialo

Gangliotriosylceramide

Biochemical Assay Reagents

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-W127324

Ganglioside GM3 (phyto-type) NeuAcα(2-3)Galβ(1-4)Glc-ceramide (phyto-type)	Biochemical Assay Reagents
Ganglioside GM3 (phyto-type) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase

Biochemical Assay Reagents

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

Cat. No.	Product Name	Target	Research Area

HY-P11094

Tet1-Cys peptide	TET Protein	Neurological Disease
Tet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor GT1b, possessing neuronal targeting capabilities. The Tet1-Cys peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research .

HY-P10529

Ganglioside GM1-binding peptide p3	Trk Receptor	Infection
Ganglioside GM1-binding peptide p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptide p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 can be used to study the interaction between GM1 and its ligands .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9914

Eculizumab 4 Publications Verification Anti-Human C5, Humanized Antibody; h5G1.1	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-P990845

*Anti-Ganglioside* GD2 Antibody (14G2a)**	Inhibitory Antibodies	Cancer
Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Ganglioside GD2. Anti-Ganglioside GD2 Antibody (14G2a) can induce neuroblastoma cells autophagy and lysis. Anti-Ganglioside GD2 Antibody (14G2a) can be used for the research of cancer, such as neuroblastoma .

HY-P99254

Racotumomab 1E10	Inhibitory Antibodies	Inflammation/Immunology Cancer
Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer .

HY-P99873

Ecromeximab KM 871; KW 2871	Inhibitory Antibodies	Others
Ecromeximab (KM 871; KW 2871) is a mouse-derived IgG-κ chimeric antibody targeting ganglioside GD3. Ecromeximab is expressed by YB2/0 rat hybridoma cells .

HY-P99743

Mitumomab	Biochemical Assay Reagents	Cancer
Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .

HY-P991639

BIW-8962	Apoptosis	Cancer
BIW-8962 is a humanized anti-ganglioside GM2 antibody. BIW-8962 exhibits ADCC/CDC activity against multiple myeloma cells. BIW-8962 demonstrates potent anti-tumor activity in mouse xenograft models. BIW-8962 is indicated for research in myeloma and other cancers .

HY-P990902A

Atigotatug (FUT8-KO) BMS-986012 (FUT8-KO)	Inhibitory Antibodies	Cancer
Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a *Fucosyl ganglioside* GM1 (fuc-GM1)**-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer .

HY-P992317

ATL301	Inhibitory Antibodies	Inflammation/Immunology Cancer
ATL301 is a human monoclonal antibody that targets human ganglioside GD2 (ganglioside GD2). GD2 is a highly expressed glycolipid antigen on the surface of neuroepithelial tumor cells, and is commonly found in neuroblastoma, melanoma, osteosarcoma, small cell lung cancer, etc.

HY-P990916

Donitabart	Inhibitory Antibodies	Inflammation/Immunology
HY-P990916 is an ganglioside GD2-targeting IgG1κ type chimeric humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10546

Ganglioside GM1	Structural Classification Natural Products Animals	iGluR Trk Receptor ERK Apoptosis Autophagy
Ganglioside GM1 is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and ERK1/2, and inhibiting oxidative stress and cell apoptosis and autophagy. Ganglioside GM1 can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Polysaccharides Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer Source Classification	Endogenous Metabolite
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-N7390

Cholesterol glucuronide	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N10511

*GM1a Ganglioside* oligosaccharide**	Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-N10526

Isoglobotriaose Gala-3Galb-4Glc	Structural Classification Polysaccharides Microorganisms Saccharides	Others
Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .

HY-N16333

C18:0 GD2 Ceramide (d18:1/18:0)	Lipid	Biochemical Assay Reagents
C18:0 GD2 Ceramide (d18:1/18:0) is a ganglioside .

HY-N15820

C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0)	Lipid	Biochemical Assay Reagents
C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0) is a ganglioside.

HY-N16004

C18:0 B Antigen ceramide (d18:1/18:0)	Lipid	Biochemical Assay Reagents
C18:0 B Antigen ceramide (d18:1/18:0) is a ganglioside.

HY-N15798

C18:0 Lc3 Ceramide (d18:1/18:0)	Lipid	Biochemical Assay Reagents
C18:0 Lc3 Ceramide (d18:1/18:0) is a ganglioside.

HY-N16029

C18:0 Fuc-GM1 Ceramide (d18:1/18:0)	Lipid	Biochemical Assay Reagents
C18:0 Fuc-GM1 Ceramide (d18:1/18:0) is a ganglioside that can be used to synthesize lipid nanoparticles for drug delivery .

HY-N15906

GM2 Sphingosine (d18:1)	Lipid	Biochemical Assay Reagents
GM2 Sphingosine (d18:1) is a precursor to the GM3 ganglioside.

HY-N16332

GM1 Sphingosine (d18:1)	Lipid	Biochemical Assay Reagents
GM1 Sphingosine (d18:1) is a precursor to the GM1 ganglioside.

HY-N16033

C18:0 Lc4 Ceramide (d18:1/18:0)	Lipid	Biochemical Assay Reagents
C18:0 Lc4 Ceramide (d18:1/18:0) is a ganglioside.

HY-N15901

Fuc-GM1 Sphingosine (d18:1)	Lipid	Biochemical Assay Reagents
Fuc-GM1 Sphingosine (d18:1) is a precursor to the Fuc-GM1 ganglioside.

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75160

	GM2A Protein, Human (sf9, His) ganglioside GM2 activator; GM2-AP; Sphingolipid activator protein 3; SAP-3	Human	Sf9 insect cells
	GM2A Protein is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. And it is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. GM2A Protein, Human (sf9, His) is the recombinant human-derived GM2A protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P71334

	ST8SIA1 Protein, Human (HEK293, His) Alpha-N-Acetylneuraminide Alpha-2; 8-Sialyltransferase; Alpha-2; 8-Sialyltransferase 8A; ganglioside GD3 Synthase; ganglioside GT3 Synthase; Sialyltransferase 8A; SIAT8-A; Sialytransferase St8Sia I; ST8SiaI; ST8SIA1; SIAT8; SIAT8A	Human	HEK293
	The ST8SIA1 protein links sialic acid to ganglioside GM3 via an α 2,8-bond to form ganglioside GD3. ST8SIA1 Protein, Human (HEK293, His) is the recombinant human-derived ST8SIA1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70954

	GM2A Protein, Human (HEK293, His) ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3	Human	HEK293
	Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. GM2A catalyzes the degradation of the ganglioside GM2 as well as affects lipid storage and neuromuscular process controlling balance. GM2A Protein, Human (HEK293, His) is the recombinant human-derived GM2A protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-114456AS

Ganglioside GM3-d5 Bovine Milk ammonium salt
Ganglioside GM3-d₅ (Bovine Milk ammonium salt) is deuterium labeled Ganglioside GM3 (Bovine Milk ammonium salt).

HY-114456S

Ganglioside GM3-d7

Ganglioside GM3-d₇ is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-166325A

Ganglioside GD3-d3 ammonium
Ganglioside GD3-d₃ ammonium is the deuterium labeled Ganglioside GD3 ammonium. Ganglioside GD3 ammonium is an ester product.

HY-152002S

Ganglioside GM3-d3 ammonium
Ganglioside GM3-d3 ammonium is a deuterated labeled Ganglioside GM3 ammonium .

HY-152003S

Ganglioside GM2-d3 ammonium

Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-146876S

*C18:0 GM1 Ganglioside-d5 ammonium*
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-165665S

*C16 Ganglioside* GM3-d9 ammonium salt**
C16 Ganglioside GM3-d₉ (ammonium salt) is deuterium labeled C16 Ganglioside GM3 (ammonium salt) .

HY-165676AS

*C16 Ganglioside* GM2-d9 (d18:1/16:0-d9) ammonium salt**
C16 Ganglioside GM2-d₉ (d₁₈:1/16:0-d₉) (C16 GM2-d₉) ammonium saltis deuterium labeled C16 Ganglioside GM2 (d18:1/16:0) (ammonium salt) .

HY-152000S

*C18 Ganglioside* GM1-d3 ammonium**
C18 Ganglioside GM1-d₃ (ammonium) is deuterium labeled C18 Ganglioside GM1 (ammonium) .

HY-165650S

*C16 Ganglioside* GM1-d9 (d18:1/16:0) ammonium**
C16 Ganglioside GM1-d₉ (d₁₈:1/16:0) (C16 GM1-d₉) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium) .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84938

	Ganglioside GM1 Antibody GM1 ganglioside; Monosialoanglioside; ganglioside GM1.	IHC-P, IHC-F, ICC/IF, FC	Rat
	Ganglioside GM1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Ganglioside GM1.

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Cat. No.	Product Name		Classification

HY-174672

Human GLB1 mRNA		mRNA
Human GLB1 mRNA encodes the human Galactosidase beta 1 (GLB1) protein, a member of the glycosyl hydrolase 35 family of proteins. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates.

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