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glutamate-cysteine ligase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Keap1-Nrf2 (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)

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Targets Recommended: Ligands for E3 Ligase E3 Ligase Ligand-Linker Conjugates ByeTAC E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126752

Ophthalmic acid	Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology
Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a K_i of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126752

Ophthalmic acid	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS)
Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a K_i of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research .

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HY-P71511

	Gamma-GCS Protein, E.coli (His-SUMO) gshA; gsh-I; b2688; JW2663glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase	E.coli	E. coli
	Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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Host:	Rabbit (5)
Reactivity:	Human (5) Rat (5) Mouse (5)
Application:	IHC-P (2) ICC/IF (3) IP (3) WB (5) FC (1) ELISA (2)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

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HY-P81662

	GCLM Antibody (YA1407) GCLM; GLCLR; glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; glutamate--cysteine ligase modifier subunit	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	GCLM Antibody (YA1407) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLM.

HY-P86557

	GCLM Antibody (YA6249) GCLM; GLCLR; glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; glutamate--cysteine ligase modifier subunit	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GCLM Antibody (YA6249) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLM.

HY-P83153

	GCLC Antibody (YA2898) GCLC; GLCL; GLCLC; glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P86305

	GCLC Antibody (YA5997) GCLC; GLCL; GLCLC; glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GCLC Antibody (YA5997) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

HY-P83153A

	GCLC Antibody (YA2898)(PBS only) GCLC; GLCL; GLCLC; glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase	WB	Human, Mouse, Rat
	GCLC Antibody (YA2898) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCLC.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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