Ophthalmic acid TFA
Based on 1 Customer Validation
Ophthalmic acid TFA, an analogue of GSH, is a marker of oxidative stress and hepatic GSH consumption. Ophthalmic acid TFA is an inhibitor of Glyoxalase I reaction.
For research use only. We do not sell to patients.
- Purity: 99.48%
- Formula: C13H20F3N3O8
- Molecular Weight:403.31
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 403.31
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Formula C13H20F3N3O8
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Color White to off-white
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SMILES
OC(CNC([C@H](CC)NC(CC[C@H](N)C(O)=O)=O)=O)=O.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (247.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Gurnit Kaur, et al. Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors. PLoS One. 2015 Sep 25;10(9):e0139299. [Content Brief]
[2]. E E CLIFFE, et al. The mechanism of the glyoxalase I reaction, and the effect of ophthalmic acid as an inhibitor. Biochem J. 1961 Jun;79(3):475-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4795 mL | 12.3974 mL | 24.7948 mL | 61.9871 mL |
| 5 mM | 0.4959 mL | 2.4795 mL | 4.9590 mL | 12.3974 mL | |
| 10 mM | 0.2479 mL | 1.2397 mL | 2.4795 mL | 6.1987 mL | |
| 15 mM | 0.1653 mL | 0.8265 mL | 1.6530 mL | 4.1325 mL | |
| 20 mM | 0.1240 mL | 0.6199 mL | 1.2397 mL | 3.0994 mL | |
| 25 mM | 0.0992 mL | 0.4959 mL | 0.9918 mL | 2.4795 mL | |
| 30 mM | 0.0826 mL | 0.4132 mL | 0.8265 mL | 2.0662 mL | |
| 40 mM | 0.0620 mL | 0.3099 mL | 0.6199 mL | 1.5497 mL | |
| 50 mM | 0.0496 mL | 0.2479 mL | 0.4959 mL | 1.2397 mL | |
| 60 mM | 0.0413 mL | 0.2066 mL | 0.4132 mL | 1.0331 mL | |
| 80 mM | 0.0310 mL | 0.1550 mL | 0.3099 mL | 0.7748 mL | |
| 100 mM | 0.0248 mL | 0.1240 mL | 0.2479 mL | 0.6199 mL |
Ophthalmic acid TFA Related Classifications
HY-126752A Related Classifications
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