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Results for "

glutathione peroxidase 4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glutathione Peroxidase (18) Apoptosis (2) Autophagy (1) Cannabinoid Receptor (1) Drug Isomer (2) Ferroptosis (20) Mitochondrial Metabolism (1) p62 (2) PROTACs (1) Reactive Oxygen Species (ROS) (9) Reference Standards (3) STING (1) Transferrin Receptor (1) TrxR (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Targets Recommended: Glutathione Peroxidase Peroxidase Enzyme Glutathione Reductase (GR) Glutathione S-transferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100218A

RSL3 Maximum Cited Publications 514 Publications Verification (1S,3R)-RSL3	p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-100002

ML162 10+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-100003

ML-210 25+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

HY-138153

JKE-1674 5+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

HY-115627

PKUMDL-LC-101-D04 5+ Cited Publications GPX4-Activator-1d4	Glutathione Peroxidase	Inflammation/Immunology
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation .

HY-141809

GPX4-IN-3 2 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

HY-100218C

(1R,3R)-RSL3 3 Publications Verification	Drug Isomer Ferroptosis	Cancer
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

HY-34765

Propiolamide	Glutathione Peroxidase Reactive Oxygen Species (ROS) Ferroptosis Apoptosis	Cancer
Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces ROS production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research .

HY-170509

Ferroptosis-IN-17	Ferroptosis Glutathione Peroxidase	Cardiovascular Disease Neurological Disease Cancer
Ferroptosis-IN-17 (Compound 18) is a ferroptosis (Ferroptosis) inhibitor with an EC₅₀ value of 0.57 μM. Ferroptosis-IN-17 reduces intracellular ferrous ion accumulation, lipid peroxidation, and effectively restores the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). Ferroptosis-IN-17 shows good solubility and significant metabolic stability in rat plasma. Ferroptosis-IN-17 is promising for research in tumor suppression, neurodegenerative diseases, and cardiovascular diseases .

HY-162106

PROTAC GPX4 degrader-2	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade **glutathione peroxidase 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis**. PROTAC GPX4 degrader-2 has anti-proliferative effect .

HY-175041

GPX4-IN-18	Glutathione Peroxidase Reactive Oxygen Species (ROS) Cannabinoid Receptor Ferroptosis	Cancer
GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4). GPX4-IN-18 is also an inducer of ferroptosis. GPX4-IN-18 can increase the production of ROS and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal cell carcinoma cells. GPX4-IN-18 induces ferroptosis in HT-1080 cells with IC₅₀s of 0.007 μM (absence of ferrostatin-1) and 1.486 μM (presence of ferrostatin-1). GPX4-IN-18 reduces in vivo tumor volume and intratumoral GPX4 levels in OS-RC-2 xenograft murine model .

HY-162944

NA-Ir	Ferroptosis Mitochondrial Metabolism STING Autophagy	Cancer
NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H₂S levels .

HY-100002R

ML162 (Standard)	Glutathione Peroxidase Reference Standards Ferroptosis	Cancer
ML162 (Standard) is the analytical standard of ML162 (HY-100002). This product is intended for research and analytical applications. ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-183294

GPX4-IN-24	Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)	Cancer
GPX4-IN-24 is an orally active **glutathione peroxidase 4 (GPX4) inhibitor with a human IC₅₀ of 10.90 μM, human K_d of 10.04 μM. GPX4-IN-24 suppresses GPX4 enzymatic activity, disrupts redox homeostasis, drives lipid peroxidation, promotes lipid peroxidation, and induces ferroptosis**. GPX4-IN-24 can be used for the research of triple-negative breast cancer .

HY-181665

Ferroptosis-IN-23	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease
Ferroptosis-IN-23 is an inhibitor of ferroptosis. Ferroptosis-IN-23 exerts a synergistic effect by simultaneously activating Steap4 and glutathione peroxidase 4 (GPX4), thereby maintaining iron metabolism homeostasis. Ferroptosis-IN-23 reverses neuronal ferroptosis and inhibits lipid ROS accumulation in cells. Ferroptosis-IN-23 inhibits ferroptosis in zebrafish, alleviates neuronal apoptosis, ROS accumulation, and dopaminergic neuron damage in a zebrafish model of Parkinson's disease. Ferroptosis-IN-23 can be used for research on Parkinson's disease .

HY-183544

Platinum(IV) Prodrug-1	TrxR Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)	Cancer
Platinum (IV) Prodrug-1 is a Pt (IV) prodrug and selective TrxR1 inhibitor. Platinum (IV) Prodrug-1 induces ferroptosis (Ferroptosis) by depleting glutathione, accumulating intracellular lipid peroxides, and inactivating **Glutathione peroxidase 4. Platinum (IV) Prodrug-1 triggers endoplasmic reticulum stress and immunogenic cell death via excessive accumulation of intracellular ROS**. Platinum (IV) Prodrug-1 exhibits anticancer activity against both Cisplatin (HY-17394)-sensitive and Cisplatin-resistant triple-negative breast cancer cells. Platinum (IV) Prodrug-1 can be used for the research of triple-negative breast cancer .

HY-100218AR

RSL3 (Standard) (1S,3R)-RSL3 (Standard)	p62 Glutathione Peroxidase Reference Standards Ferroptosis Reactive Oxygen Species (ROS)	Cancer
RSL3 (Standard) is the analytical standard of RSL3 (HY-100218A). This product is intended for research and analytical applications. RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-180199

GPX4-IN-21	Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)	Cancer
GPX4-IN-21 (Compound 4d) is a selective **glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS** and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma .

HY-181953

STIM1-TFR1-IN-1	Transferrin Receptor Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase	Neurological Disease
STIM1-TFR1-IN-1 is an orally active stromal interaction molecule 1 (STIM1)-transferrin receptor 1 (TFR1) protein complex inhibitor with a K_d of 2.18 μM for STIM1-CD protein. STIM1-TFR1-IN-1 blocks STIM1-TFR1 interaction and reduce TFR1-mediated iron uptake activity. STIM1-TFR1-IN-1 inhibits ferroptosis, lipid peroxidation and ROS production, enhances glutathione peroxidase 4 (GPX4) activity and glutathione/oxidized glutathione ratio, and rescues ferroptosis-associated mitochondrial morphological changes. STIM1-TFR1-IN-1 exhibits neuroprotective effects and reduces brain injury. STIM1-TFR1-IN-1 can be used for the research of intracerebral hemorrhage .

HY-100218CR

(1R,3R)-RSL3 (Standard)	Drug Isomer Ferroptosis Reference Standards	Cancer
(1R,3R)-RSL3 (Standard) is the analytical standard of (1R,3R)-RSL3 (HY-100218C). This product is intended for research and analytical applications. (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library	1,177 compounds
Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 1,177 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Ferroptosis Compound Library

1,177 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 1,177 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Species:	Human (2)
Tag:	His (1) Flag (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702646

	GPX4 Protein, Human (U73S, His) PHGPx; glutathione peroxidase 4; GPx-4; GSHPx-4	Human	E. coli
	GPX4 Protein, Human (U73S, His) is the recombinant human-derived GPX4, expressed by E. coli , with N-6*His labeled tag. ,

HY-P703942

	GPX4 Protein, Human (U73C, HEK293, Flag) Phospholipid hydroperoxide glutathione peroxidase; PHGPx; glutathione peroxidase 4; GPx-4; GSHPx-4	Human	HEK293
	GPX4 Protein, Human (U73C, HEK293, Flag) is the recombinant human-derived GPX4 protein, expressed by HEK293, with N-Flag tag.

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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (3) ICC/IF (4) IP (1) IHC-F (2) WB (4) FC (1) ELISA (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Polyclonal (1) Monoclonal (3) Recombinant (3)
Modification:	Unmodified (4)

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HY-P86239

	GPX4 Antibody (YA5931) Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; PHGPx; glutathione peroxidase 4; GPx-4; GSHPx-4;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GPX4 Antibody (YA5931) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPX4.

HY-P80692

	GPX4 Antibody 4 Publications Verification Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; glutathione peroxidase 4; GPx-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	GPX4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GPX4.

HY-P80692A

	GPX4 Antibody (YA9649)(PBS only) Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; glutathione peroxidase 4; GPx-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	GPX4 Antibody(YA9649)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPX4.

HY-P80450A

	GPX4 Antibody (YA399)(PBS only) Phospholipid hydroperoxide glutathione peroxidase GPX4, PHGPx, glutathione peroxidase 4, GPx-4, GSHPx-4, Gpx4	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	GPX4 Antibody (YA399) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPX4.

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