2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Glutathione Peroxidase Reactive Oxygen Species (ROS) Ferroptosis Apoptosis
  4. Propiolamide

Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces ROS production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research.

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Propiolamide

Propiolamide Chemical Structure

CAS No. : 7341-96-0

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Propiolamide Related Antibodies

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Description

Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces ROS production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research[1].

IC50 & Target[1]

GPX4

 

In Vitro

Propiolamide (14 mM; 0-30 min) induces microsomal monooxygenase-mediated reactive oxygen species production in CYP3A4/CPR/Cyt c and CYP3A4/NADPH systems[1].
Propiolamide (38 μM) inhibits the activity of glutathione peroxidase 4 derived from bovine red blood cells by 46%[1].
Propiolamide (30-50 μM; 12 h) induces apoptosis in HeLa cells in a concentration-dependent manner in vitro. After 12 hours of treatment, the proportion of total apoptotic cells reaches 7.13% at 30 μM and 10.33% at 50 μM[1].
Propiolamide (50 μM; 12 h) promotes lipid peroxidation in HeLa cells, which is a key marker of ferroptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propiolamide Related Antibodies

Apoptosis Analysis[1]

Cell Line: HeLa human cervical cancer cells
Concentration: 30 μM; 50 μM
Incubation Time: 12 h
Result: Increased total apoptotic cells (early + late stage) from 4.30% (untreated control) to 7.13% at 30 μM.
Further increased total apoptotic cells to 10.33% at 50 μM.
Molecular Weight

69.06

Formula

C3H3NO
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C#C)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation

Purity: 99.94%

SDS (394 KB)

COA (246 KB) HNMR (94 KB) GC (185 KB)

Handling Instructions (2659 KB)
References
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Propiolamide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propiolamide7341-96-0Glutathione PeroxidaseReactive Oxygen Species (ROS)FerroptosisApoptosisselenocysteine residuelipid peroxideHeLa cellsCYP3A4/NADPH systemCYP3A4/CPR/Cyt c systemapoptotic pathwaysreactive oxygen speciescancermonooxygenase systemglutathione peroxidase 4Inhibitorinhibitorinhibit

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