142 Results for "

groove

" in MedChemExpress (MCE) Product Catalog:
Products (142)

142 Results for "groove" in MCE Product Catalog:

184
DAPI dihydrochloride
DAPI dihydrochloride
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184 Publications Verification
Cat. No.: HY-D0814
CAS No.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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184
DAPI
DAPI
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184 Publications Verification
Cat. No.: HY-D2868
CAS No.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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178
DAPI dilactate
DAPI dilactate
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178 Cited Publications
Cat. No.: HY-D1738
CAS No.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
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163
Hoechst 33342
Hoechst 33342
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163 Cited Publications
Cat. No.: HY-15559
CAS No.: 23491-52-3
Purity:  99.94%
Synonyms: bisBenzimide H 33342; HOE 33342
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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163
Hoechst 33342 trihydrochloride
Hoechst 33342 trihydrochloride
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163 Cited Publications
Cat. No.: HY-15559A
CAS No.: 875756-97-1
Purity:  99.81%
Synonyms: bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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25
Hoechst 33258 trihydrochloride
Hoechst 33258 trihydrochloride
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25 Cited Publications
Cat. No.: HY-15558A
CAS No.: 23491-45-4
Purity:  99.51%
Synonyms: bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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25
Hoechst 33258
Hoechst 33258
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25 Cited Publications
Cat. No.: HY-15558
CAS No.: 23491-44-3
Purity:  99.11%
Synonyms: bisBenzimide H 33258; H 33258
Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .
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9
Lurbinectedin
Lurbinectedin
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9 Cited Publications
Cat. No.: HY-16293
CAS No.: 497871-47-3
Synonyms: PM01183; LY-01017
Target:  

DNA Alkylator/Crosslinker DNA/RNA Synthesis

Research Areas:  

Cancer

Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
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7
Tesirine
Tesirine
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7 Cited Publications
Cat. No.: HY-128952
CAS No.: 1595275-62-9
Purity:  98.10%
Synonyms: SG3249
Target:  

Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker

Research Areas:  

Cancer

Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
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7
Hoechst 34580
Hoechst 34580
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7 Cited Publications
Cat. No.: HY-15560
CAS No.: 23555-00-2
Synonyms: HOE 34580
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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7
Hoechst 34580 tetrahydrochloride
Hoechst 34580 tetrahydrochloride
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7 Cited Publications
Cat. No.: HY-15560B
CAS No.: 2310135-08-9
Purity:  99.47%
Synonyms: HOE 34580 tetrahydrochloride
Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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7
Hoechst 33258 analog 6
Hoechst 33258 analog 6
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7 Cited Publications
Cat. No.: HY-15631
CAS No.: 129244-66-2
Purity:  99.63%
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution (Ex/Em = 356/451 nm) .
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6
Hoechst 33342 analog
Hoechst 33342 analog
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6 Cited Publications
Cat. No.: HY-15627
CAS No.: 178481-68-0
Purity:  98.16%
Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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5
UMI-77
UMI-77
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5 Cited Publications
Cat. No.: HY-18628
CAS No.: 518303-20-3
Target:  

Bcl-2 Family

Research Areas:  

Cancer

UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
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5
SYBR green I chloride
SYBR green I chloride
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5 Cited Publications
Cat. No.: HY-D1191
CAS No.: 2225748-05-8
SYBR Green I chloride is a highly sensitive fluorescent nucleic acid dye that binds specifically to the minor groove of double-stranded DNA or intercalates between base pairs. SYBR Green I chloride exhibits weak fluorescence in the unbound state but emits bright fluorescence upon binding, and it preferentially binds to large-fragment DNA and DNA with high G+C content. SYBR Green I chloride is suitable for real-time PCR technology; its fluorescence intensity correlates with the amount and size of amplification products, enabling accurate quantification of gene expression and discrimination of amplicons via melting curve analysis without additional post-processing. SYBR Green I chloride is widely used in preclinical in vitro nucleic acid detection .
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5
(S)-Gossypol (acetic acid)
(S)-Gossypol (acetic acid)
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5 Cited Publications
Cat. No.: HY-15464D
CAS No.: 1189561-66-7
Purity:  98.39%
Synonyms: (S)-(+)-Gossypol acetic acid
Target:  

Bcl-2 Family

Research Areas:  

Cancer

(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
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3
SG3199
SG3199
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3 Cited Publications
Cat. No.: HY-101161
CAS No.: 1595275-71-0
Purity:  98.94%
Target:  

DNA Alkylator/Crosslinker ADC Payloads

Research Areas:  

Cancer

SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
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3
Fz7-21
Fz7-21
0 Images
3 Cited Publications
Cat. No.: HY-P1454
CAS No.: 2247635-23-8
Synonyms: Ac-LPSDDLEFWCHVMY-NH2
Target:  

Wnt

Research Areas:  

Cancer

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .
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3
Fz7-21 TFA
Fz7-21 TFA
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3 Cited Publications
Cat. No.: HY-P1454A
Synonyms: Ac-LPSDDLEFWCHVMY-NH2 TFA
Target:  

Wnt

Research Areas:  

Cancer

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids .
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3
ortho-iodoHoechst 33258
ortho-iodoHoechst 33258
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3 Cited Publications
Cat. No.: HY-15626
CAS No.: 158013-41-3
Purity:  98.01%
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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