Search Result

Results for "

heme oxygenase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Heme Oxygenase (HO) (13) Akt (1) Apoptosis (9) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (2) CDK (1) COX (1) Dengue Virus (1) Drug Derivative (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (8) Epigenetic Reader Domain (2) Ferroptosis (1) Fungal (1) GSK-3 (1) IFNAR (2) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (12) Mitochondrial Metabolism (1) Monoamine Oxidase (1) mTOR (1) NF-κB (3) NO Synthase (3) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (3) PKC (2) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (23) Reference Standards (6) Ribosomal S6 Kinase (RSK) (2) TNF Receptor (2) Tyrosinase (1) β-catenin (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (7) Infection (6) Inflammation/Immunology (13) Metabolic Disease (5) Neurological Disease (9)

By Targets:

Heme Oxygenase (HO) (13)

Akt (1)

Apoptosis (9)

Autophagy (3)

Bacterial (2)

Biochemical Assay Reagents (2)

CDK (1)

COX (1)

Dengue Virus (1)

Drug Derivative (1)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (8)

Epigenetic Reader Domain (2)

Ferroptosis (1)

Fungal (1)

GSK-3 (1)

IFNAR (2)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (12)

Mitochondrial Metabolism (1)

Monoamine Oxidase (1)

mTOR (1)

NF-κB (3)

NO Synthase (3)

NOD-like Receptor (NLR) (1)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (3)

PKC (2)

Potassium Channel (1)

PPAR (1)

Prostaglandin Receptor (2)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (23)

Reference Standards (6)

Ribosomal S6 Kinase (RSK) (2)

TNF Receptor (2)

Tyrosinase (1)

β-catenin (1)

By Research Areas:

Cancer (22)

Cardiovascular Disease (7)

Infection (6)

Inflammation/Immunology (13)

Metabolic Disease (5)

Neurological Disease (9)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Protéines recombinantes

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Heme Oxygenase (HO)

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-101193

Zinc Protoporphyrin Maximum Cited Publications 67 Publications Verification Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9	Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity .

HY-N0643

Carnosol 15+ Cited Publications	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-101194

Tin protoporphyrin IX dichloride 15+ Cited Publications Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX	Reactive Oxygen Species (ROS)	Cancer
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .

HY-111798A

Heme Oxygenase-1-IN-1 hydrochloride 10+ Cited Publications	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC₅₀ of 0.25 μM .

HY-111798

Heme Oxygenase-1-IN-1 10+ Cited Publications	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .

HY-134608

Cobalt protoporphyrin IX Co-PPIX	Reactive Oxygen Species (ROS) Influenza Virus	Infection
Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) .

HY-W013812

Ethyl linoleate Linoleic Acid ethyl ester; Mandenol	Tyrosinase Akt GSK-3 β-catenin Biochemical Assay Reagents NF-κB Heme Oxygenase (HO)	Cardiovascular Disease Inflammation/Immunology
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces **heme oxygenase-1 and inhibits tyrosinase**. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics

HY-N0061

Ethyl ferulate 3 Publications Verification	Reactive Oxygen Species (ROS)	Neurological Disease
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .

HY-B2184

Sofalcone 2 Publications Verification	Autophagy Bacterial	Infection Inflammation/Immunology
Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1 (HO-1**) in gastric epithelium.

HY-B1817A

Zinc acetate, 99.99% trace metals basis Zinc(II) acetate, 99.99% trace metals basis	CDK Heme Oxygenase (HO) Apoptosis	Others
Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a **heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E** and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions .

HY-131592

Tricetin 1 Publications Verification	Apoptosis Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-N0381

Maackiain 1 Publications Verification DL-Maackiain	Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus	Infection Neurological Disease Metabolic Disease
Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。

HY-118487

OB-24 2 Publications Verification	Heme Oxygenase (HO) Reactive Oxygen Species (ROS)	Cancer
OB-24 is a selective small-molecule HO-1 inhibitor (IC₅₀ = 1.9 μM for HO-1 and IC₅₀ for HO-2 >100 μM). OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis .

HY-147517

Keap1-Nrf2-IN-9	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-124815

CP-312	Reactive Oxygen Species (ROS)	Others
CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress .

HY-162857

Heme Oxygenase-1-IN-3	Heme Oxygenase (HO)	Neurological Disease Cancer
Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (K_d=141 nM) that can be used in the research of cancer and neurodegenerative diseases .

HY-101193R

Zinc Protoporphyrin (Standard) Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-106359A

Delmitide acetate RDP-58 acetate	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Cancer
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .

HY-N1506

Ganodermanontriol	Epigenetic Reader Domain p38 MAPK	Cancer
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity .

HY-115713

Heme Oxygenase-1-IN-2	Reactive Oxygen Species (ROS)	Cancer
Heme Oxygenase-1-IN-2 is a novel **heme oxygenase-1 inhibitor (IC₅₀** = 0.95 μM) with potent in vitro antiproliferative activity.

HY-106359

Delmitide RDP-58	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis .

HY-161601

Ferroptosis inducer-2	Ferroptosis Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer-2 (Compound 24) is an inducer for heme oxygenase-1 (HO-1). Ferroptosis inducer-2 exhibits anticancer activity against triple-negative breast cancer (TNBC) cells through induction of ferroptosis .

HY-175660

KCL-HO-1i	Heme Oxygenase (HO)	Cancer
KCL-HO-1i is an orally active **heme oxygenase-1 (HO-1) inhibitor (rat HO-1: IC₅₀ = 123 nM) and human HO-1: IC₅₀** = 128 nM). KCL-HO-1i targets immunosuppressive LYVE-1 ⁺ perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME), reduces PvTAM-mediated immune exclusion. KCL-HO-1i demonstrates synergistic anti-tumor efficacy with chemotherapy in MMTV-PyMT spontaneous breast cancer mice or C57Bl/6 mice bearing subcutaneous MN-MCA1 sarcomas. KCL-HO-1i can be used for the study of cancer .

HY-W478741

Pyrraline	Endogenous Metabolite Keap1-Nrf2 NF-κB	Metabolic Disease Cancer
Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers .

HY-118487A

OB-24 free base	Endogenous Metabolite	Cancer
OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol .

HY-170867

Nrf2/HO-1 activator 3	Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H₂O₂- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy .

HY-P11124

MGF24	Apoptosis PKC Keap1-Nrf2 Heme Oxygenase (HO) Drug Derivative	Neurological Disease
MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research .

HY-N0643R

Carnosol (Standard)	Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-153020

HIF-PHD-IN-3	Reactive Oxygen Species (ROS)	Cardiovascular Disease
HIF-PHD-IN-3 (compound 4) is a potent hiPSC-CM cardioprotective scaffold. HIF-PHD-IN-3 can induce upregulation of **heme oxygenase-1** .

HY-B2184S

Sofalcone-d4	Isotope-Labeled Compounds	Infection Inflammation/Immunology
Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1 (HO-1**) in gastric epithelium.

HY-B2184R

Sofalcone (Standard)	Reference Standards Autophagy Bacterial	Infection Inflammation/Immunology
Sofalcone (Standard) is the analytical standard of Sofalcone. This product is intended for research and analytical applications. Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1 (HO-1**) in gastric epithelium.

HY-124815R

CP-312 (Standard)	Reactive Oxygen Species (ROS)	Others
CP-312 (Standard) is the analytical standard of CP-312. This product is intended for research and analytical applications. CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress .

HY-N0761AS

trans-Isoferulic acid-d3	Prostaglandin Receptor NO Synthase	Inflammation/Immunology
trans-Isoferulic acid-d₃ is the deuterium labeled trans-Isoferulic acid . trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-N2535R

Coniferaldehyde (Standard) 4-Hydroxy-3-methoxycinnamaldehyde (Standard)	Reference Standards Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-N0761AR

trans-Isoferulic acid (Standard) trans-3-Hydroxy-4-methoxycinnamic acid (Standard)	Reference Standards NO Synthase Prostaglandin Receptor	Inflammation/Immunology
trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-P11589

PIISVYWK	PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2	Metabolic Disease
PIISVYWK is an orally active PPARγ Inhibitor, **heme oxygenase-1 Activator, and Nrf2** Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity .

HY-W424839

Probucol dithiobisphenol DTBP	Heme Oxygenase (HO)	Cardiovascular Disease
Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of **heme oxygenase 1 (HO-1*), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in Apoe ^−/−* mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active .

HY-N1506R

Ganodermanontriol (Standard)	Reference Standards Epigenetic Reader Domain Others p38 MAPK	Cancer
Karbutilate (Standard) is the analytical standard of Karbutilate. This product is intended for research and analytical applications. Karbutilate (NIA-11092) is a nonselective soil-active herbicide which is used to kill one-leaf pinyon saplings .

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species (ROS)	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases *heme-oxygenase* 1 and 2 mRNA levels that play role in cellular defense against *reactive oxygen* species** .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species (ROS)	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases *heme-oxygenase* 1 and 2 mRNA levels that play role in cellular defense against *reactive oxygen* species** .

HY-173518

SIN 14	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) NO Synthase COX Interleukin Related	Inflammation/Immunology
SIN 14, a derivative of Sinomenine (HY-15122), is an orally active HO-1 activator (K_D = 17.2 μM). SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides)(HY-D1056)-induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO, IL-6, IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of COX-2 and iNOS. SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice .

HY-112749B

(3S,4R)-ME-344	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cancer
(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research .

HY-182604

QC-308	Heme Oxygenase (HO)	Cancer
QC-308 is a HO-1/HO-2 inhibitor with an HO-1 IC₅₀ of 0.27 μM and an HO-2 IC₅₀ of 0.46 μM. QC-308 coordinates heme iron(II) to disrupt catalysis. QC-308 can be used for research of HO-1 inhibition mechanisms in cancer .

HY-180529

4-Octyl itaconate-Bn-S-NH2	Keap1-Nrf2 Reactive Oxygen Species (ROS) Potassium Channel	Cardiovascular Disease
4-Octyl itaconate-Bn-S-NH2 (Compound 8b) is a vasodilator. 4-Octyl itaconate-Bn-S-NH2 can slowly and stably release H₂S, and it alleviates oxidative stress through an antioxidant reaction that depends on the activation of Nrf2. 4-Octyl itaconate-Bn-S-NH2 inhibits the production of intracellular ROS caused by H₂O₂ damage and the cytotoxicity of cells, and activates potassium channel. 4-Octyl itaconate-Bn-S-NH2 can be used for research on hypertension .

HY-W679138

N,N-dimethyldithiocarbamate potassium	E1/E2/E3 Enzyme Heme Oxygenase (HO)	Neurological Disease
N,N-dimethyldithiocarbamate potassium is a ubiquitin-activating enzyme E1 inhibitor. N,N-dimethyldithiocarbamate potassium inhibits the activation of E1 and reduces the level of activated ubiquitinated E1 (ub-E1). N,N-dimethyldithiocarbamate potassium increases intracellular copper levels, enhances oxidative stress, elevates protein carbonyl levels, and upregulates the expression of HO-1 . N,N-dimethyldithiocarbamate potassium is applicable to research related to Parkinson's disease .

HY-N17406

Dankasterone A	Endogenous Metabolite Fungal Heme Oxygenase (HO) Apoptosis Reactive Oxygen Species (ROS)	Cancer
Dankasterone A is a secondary metabolite. Dankasterone A can be derived from the Fungus Talaromyces purpurogenu. Dankasterone A upregulates HO-1 protein expression, induces Apoptosis, induces excessive ROS production. Dankasterone A has anti-cancer activity against prostate cancer .

Cat. No.	Nom du produit	Type

HY-B1817A

Zinc acetate, 99.99% trace metals basis

Zinc(II) acetate, 99.99% trace metals basis

Biochemical Assay Reagents

Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

Cat. No.	Nom du produit	Target	Research Area

HY-106359A

Delmitide acetate RDP-58 acetate	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Cancer
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .

HY-106359

Delmitide RDP-58	TNF Receptor IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis .

HY-P11124

MGF24	Apoptosis PKC Keap1-Nrf2 Heme Oxygenase (HO) Drug Derivative	Neurological Disease
MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research .

HY-P11589

PIISVYWK	PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2	Metabolic Disease
PIISVYWK is an orally active PPARγ Inhibitor, **heme oxygenase-1 Activator, and Nrf2** Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity .

Species:	Human (1) Mouse (1)
Tag:	His (1) Tag Free (1)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Nom du produit	Species	Source	Image

HY-P70276

	HO-1 Protein, Human 2 Publications Verification rHuheme oxygenase 1/HO-1; heme oxygenase 1; HO-1; HMOX1; HO; HO1	Human	E. coli
	HO-1 Protein, an enzyme, plays a critical role in cellular defense against oxidative stress and inflammation. Dysregulation of HO-1 Protein has been implicated in several diseases, including cardiovascular disorders and neuroinflammatory conditions. Targeting HO-1 Protein may offer potential therapeutic interventions by enhancing antioxidant defenses, reducing inflammation, and potentially treating these diseases. HO-1 Protein, Human is the recombinant human-derived HO-1 protein, expressed by E. coli , with tag free.

HY-P700495

	HO-1 Protein, Mouse (P. pastoris, His) rHuheme oxygenase 1/HO-1; heme oxygenase 1; HO-1; HMOX1; HO; HO1	Mouse	P. pastoris
	HO-1 Protein catalyzes the oxidative cleavage of heme, releasing carbon monoxide (CO) and ferrous iron. It provides protection against programmed cell death by catabolizing free heme, preventing apoptosis sensitization. HO-1 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived HO-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

Compare Products


Products	En stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / En stock - + Ajouter au chariot Obtenir un devis

Cat. No.	Nom du produit	Chemical Structure

HY-B2184S

Sofalcone-d4
Sofalcone-d₄ is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of **Heme oxygenase-1 (HO-1**) in gastric epithelium.

HY-N0761AS

trans-Isoferulic acid-d3
trans-Isoferulic acid-d₃ is the deuterium labeled trans-Isoferulic acid . trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (2) Mouse (2)
Application:	IHC-P (5) ICC/IF (2) IP (2) WB (3) FC (3) ELISA (3)
Isotype:	IgG (1) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Nom du produit	Application	Reactivity	Image

HY-P85707

	Heme Oxygenase 1 Antibody (YA5399) heme oxygenase 1; HO-1;	IHC-P, WB, ICC/IF	Human, Mouse, Rat
	Heme Oxygenase 1 Antibody (YA5399) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P86395

	Heme Oxygenase 1 Antibody (YA6087) heme oxygenase 1 (HO-1) (EC 1.14.99.3)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Heme Oxygenase 1 Antibody (YA6087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P80499

	Heme Oxygenase 1 Antibody (YA389) 1 Publications Verification	WB, IHC-P, IP, FC	Human
	Heme Oxygenase 1 Antibody (YA389) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P84030

	Heme Oxygenase 1 Antibody (YA3727) HO-1; HSP32; HMOX1D; bK286B10	IHC-P, FC, ELISA	Human
	Heme Oxygenase 1 Antibody (YA3727) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Heme Oxygenase 1.

HY-P84030A

	Heme Oxygenase 1 Antibody (YA3727)(PBS only) HO-1; HSP32; HMOX1D; bK286B10	IHC-P, FC, ELISA	Human
	Heme Oxygenase 1 Antibody (YA3727) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Heme Oxygenase 1.

Compare Products


Products	En stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / En stock - + Ajouter au chariot Obtenir un devis

Demande en ligne

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Civilité			Country or Region *
Nom du demandeur *			Nom de l'organisation *
Department *
Adresse e-mail *			Nom du produit *
Cat. No.			Requested quantity *
Numéro de téléphone *
Remarques

Demande en ligne

Inquiry Information

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

heme oxygenase-1

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Protéines recombinantes

Isotope-Labeled Compounds

Antibodies

Natural
Products