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hiCE

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By Targets:	Autophagy (2) Carboxylesterase (CES) (3) Cholinesterase (ChE) (3) Opioid Receptor (2) Reference Standards (2)
By Research Areas:	Cancer (5) Metabolic Disease (4) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0418A

Loperamide hydrochloride 10+ Cited Publications R-18553 hydrochloride	Opioid Receptor Autophagy	Neurological Disease Metabolic Disease Cancer
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .

HY-N10686

Tanshinone IIA anhydride	Carboxylesterase (CES)	Cancer
Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a K_i value of 1.9 nM against hCE1 and a K_i value of 1.4 nM against *hiCE*. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies .

HY-B0418AR

Loperamide hydrochloride (Standard) 5+ Cited Publications R-18553 hydrochloride (Standard)	Reference Standards Opioid Receptor Autophagy	Neurological Disease Metabolic Disease Cancer
Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .

HY-103610

4,4'-Dimethoxybenzil p-Anisil	Cholinesterase (ChE)	Cancer
4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with K_i of 70 nM.

HY-23148

1-Methylisatin N-Methylisatin	Carboxylesterase (CES)	Others
1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with K_is of 38.2 and 5.38 μM for *hiCE* and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .

HY-147388

hiCE inhibitor-1	Cholinesterase (ChE)	Metabolic Disease
hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a K_i value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea .

HY-124446

Dibromsalicil	Carboxylesterase (CES)	Metabolic Disease
Dibromsalicil (Compound 31) is a carboxylesterase (CES) inhibitor with activity of 72.7 nM against *hiCE* (human intestinal carboxylesterase) and 53.5 nM against rCE (rabbit liver carboxylesterase). Dibromsalicil has almost no activity against hCE1 (human liver carboxylesterase) and cholinesterase .

HY-103610R

4,4'-Dimethoxybenzil (Standard) p-Anisil (Standard)	Cholinesterase (ChE) Reference Standards	Cancer
4,4'-Dimethoxybenzil (Standard) is the analytical standard of 4,4'-Dimethoxybenzil (HY-103610). This product is intended for research and analytical applications. 4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with K_i of 70 nM.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10686

Tanshinone IIA anhydride	Structural Classification Flavonoids Labiatae Samanea saman (Jacq.) Merr. Plants Other Flavonoids Source Classification	Carboxylesterase (CES)
Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a K_i value of 1.9 nM against hCE1 and a K_i value of 1.4 nM against *hiCE*. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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hiCE

Inhibitors & Agonists

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Natural
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