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human A2B adenosine receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (17) Cyclic GMP-AMP Synthase (1) Isotope-Labeled Compounds (1) Nucleoside Antimetabolite/Analog (1) PI3K (2) Reference Standards (4)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Inflammation/Immunology (12) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Adenosine Kinase Adenosine Deaminase Adenosine Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14121

MRS 1754 Maximum Cited Publications 8 Publications Verification	Adenosine Receptor	Metabolic Disease Inflammation/Immunology
MRS 1754 is a selective antagonist radioligand for **A_2B adenosine receptor** with very low affinity for A₁ and A₃ receptors of both humans and rats .

HY-100678

CGS 15943	Adenosine Receptor PI3K	Inflammation/Immunology Cancer
CGS 15943 is an orally bioavailable non-xanthine **Adenosine Receptor antagonist. Its K_i** for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-103166

PSB-603 3 Publications Verification	Adenosine Receptor	Inflammation/Immunology
PSB-603 is a potent and highly selective **A_2B adenosine receptor antagonist exhibiting a K_i** value of 0.553 nM and virtually no affinity for the human and rat A₁ and A_2A and the human A₃ receptors up to a concentration of 10 μM .

HY-10081

GS-6201 1 Publications Verification CVT-6883	Adenosine Receptor	Inflammation/Immunology
GS-6201 (CVT-6883) is a selective **adenosine A2B receptor** antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (K_i=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-W587488

Adenosine 3′-monophosphate 3′-AMP	Nucleoside Antimetabolite/Analog Cyclic GMP-AMP Synthase	Cancer
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via *A_2B* receptors .

HY-103186

MRS-1706 1 Publications Verification	Adenosine Receptor	Inflammation/Immunology
MRS-1706 is a potent and selective **adenosine A_2B receptor inverse agonist. MRS-1706 has K_i** values of 1.39, 112, 157, and 230 nM for human A_2B, A_2A, A₁ and A₃ receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .

HY-111767

BAY-545	Adenosine Receptor	Inflammation/Immunology
BAY-545 is a potent and selective **A_2B adenosine receptor antagonist, with an IC₅₀ of 59 nM. BAY-545 also exhibits IC₅₀*s of 66, 400, 280 nM for human, mouse, rat A_2B* adenosine receptor in cells, respectively, and a K_i of 97 nM for human A_2B adenosine receptor, with more selectivity over A₁, A_2A, and A₃ adenosine receptor .

HY-153897

PSB-1901	Adenosine Receptor	Cancer
PSB-1901 is a potent A_2B adenosine receptor (A_2BAR) antagonist with K_is of 0.0835 nM and 0.131 nM for human and mouse A_2BARs respectively. PSB-1901 can be used for the research of cancer .

HY-129092

8-(p-Sulfophenyl)theophylline 8-SPT; 8-pSPT	Adenosine Receptor	Others
8-(p-Sulfophenyl)theophylline (8-SPT) (compound 2) is an **adenosine A2B receptor antagonist, with a K_i** of 1330 nM for A2B human recombinant .

HY-14873

Tonapofylline BG 9928	Adenosine Receptor	Cardiovascular Disease Metabolic Disease
Tonapofylline (BG 9928) is an orally active and selective **adenosine A₁ receptor antagonist with a K_i** of 7.4 nM for human adenosine A₁ receptor (hA₁), which displays 915-fold selectivity versus human adenosine A_2A receptor and 12-fold selectivity versus human adenosine A_2B receptor and is used in development for the treatment of heart failure .

HY-103186R

MRS-1706 (Standard)	Reference Standards Adenosine Receptor	Inflammation/Immunology
MRS-1706 (Standard) is the analytical standard of MRS-1706. This product is intended for research and analytical applications. MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .

HY-14121R

MRS 1754 (Standard)	Adenosine Receptor	Metabolic Disease Inflammation/Immunology
MRS 1754 (Standard) is the analytical standard of MRS 1754. This product is intended for research and analytical applications. MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats .

HY-100678R

CGS 15943 (Standard)	Reference Standards Adenosine Receptor PI3K	Inflammation/Immunology Cancer
CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-A0168S

Regadenoson-d3 CVT-3146-d₃	Isotope-Labeled Compounds Adenosine Receptor	Cardiovascular Disease Cancer
Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

HY-183599

MK-1088	Adenosine Receptor	Cancer
MK-1088 is an orally active **A_2A/A_2B adenosine receptor** antagonist with human A_2A K_i of 0.31 nM, human A_2B K_i 5.3 nM. MK-1088 blocks receptor downstream signaling, inhibits CREB phosphorylation and reverses adenosine-mediated immunosuppression. MK-1088 restores TNF−α release and enhances tumor immune surveillance. MK-1088 can be used for the research of cancer^[1].

HY-10081R

GS-6201 (Standard) CVT-6883 (Standard)	Adenosine Receptor Reference Standards	Inflammation/Immunology
GS-6201 (Standard) is the analytical standard of GS-6201 (HY-10081). This product is intended for research and analytical applications. GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-103166R

PSB-603 (Standard)	Reference Standards Adenosine Receptor	Inflammation/Immunology
PSB-603 (Standard) is the analytical standard of PSB-603 (HY-103166). This product is intended for research and analytical applications. PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a K_i value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM .

HY-183993

A3AR antagonist-8	Adenosine Receptor	Neurological Disease Inflammation/Immunology Cancer
A3AR antagonist-8 is a selective A3 adenosine receptor antagonist with a K_i of 98 nM for human A3 adenosine receptor. A3AR antagonist-8 can be used for the research of glaucoma, chronic renal disease, acute renal ischemia and reperfusion injury, and cancer .

Cat. No.	Product Name	Chemical Structure

HY-A0168S

Regadenoson-d3
Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

Regadenoson-d3

Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

Cat. No.	Product Name		Classification

HY-W587488

Adenosine 3′-monophosphate 3′-AMP		Nucleotide Analogs Adenine Nucleotide
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via *A_2B* receptors .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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