84-21-9
84-21-9
Chemical Structure
Adenosine 3′-monophosphate
Synonym(s): 3′-AMP
- CAS 番号: 84-21-9
- Formula:C10H14N5O7P
- Molecular Weight:347.22
IUPAC Name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate
InChIKey: LNQVTSROQXJCDD-KQYNXXCUSA-N
SMILES: NC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C=N2)=NC=N1
Biological Activity: Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors[1][2][3].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Adenosine 3′-monophosphate | 99% | Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. | ||||||||||||||||||||
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Adenosine-2'-monophosphate (Standard) | ≥98% | Adenosine-2'-monophosphate (Standard) (2'-AMP (Standard)) is the analytical standard of Adenosine-2'-monophosphate (HY-124151). This product is intended for research and analytical applications. Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation. | ||||||||||||||||||||
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5'-AMPS | 5'-AMPS is an analogue of 5'-AMP and a substrate and competitive inhibitor or regulator of enzymes that interact with 5'-AMP. | |||||||||||||||||||||
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2'-O-methyladenosine 5'-phosphate | 2'-O-methyladenosine 5'-phosphate is the nucleotide complex group of ribosomes and is mainly used for DNA conjugation. 2'-O-methyladenosine 5'-phosphate is used to prepare RNA vaccines and is the main part of the RNA molecule, while the 5'-end is blocked by 2'-O-Methylguanosine 5'-monophosphate. | |||||||||||||||||||||
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Adenosine-3',5'-bisphosphate | Adenosine-3',5'-bisphosphate is an exoribonuclease XRN1 inhibitor with an IC50 of 36 nM, a KD of 12 nM, and a KD of 14 nM against human XRN2. Adenosine-3',5'-bisphosphate binds to the bimetallic active site of human XRN1, and also binds potently to human XRN2 via its conserved bimetallic active site. Adenosine-3',5'-bisphosphate can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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Adenosine 5'-monophosphate monohydrate (Standard) | 98.91% | Adenosine 5'-monophosphate monohydrate (Standard) (5'-AMP monohydrate (Standard)) is the analytical standard of Adenosine 5'-monophosphate monohydrate (HY-A0181A). This product is intended for research and analytical applications. Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2. | ||||||||||||||||||||
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Adenosine monophosphate (Standard) | 99.69% | Adenosine monophosphate (Standard) is the analytical standard of Adenosine monophosphate (HY-A0181). This product is intended for research and analytical applications. Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction. | ||||||||||||||||||||
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Adenosine-15N5 | 99.9% | Adenosine-15N5 (Adenine riboside-15N5; D-Adenosine-15N5) is the 15N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. | ||||||||||||||||||||
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Adenosine-1′-13C | 96.27% | Adenosine-1′-13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo | ||||||||||||||||||||
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Vidarabine phosphate | 99.44% | Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis. | ||||||||||||||||||||
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3′-O-Methyladenosine | 99.66% | (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (Adenosine, 3'-O-methyl- (8CI)(9CI)) is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). | ||||||||||||||||||||
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References
- [1]. S Ohkubo, et al. Effects of AMP derivatives on cyclic AMP levels in NG108-15 cells. Br J Pharmacol. 2000 Mar;129(6):1244-50. [Content Brief]
- [2]. Ellis, G., et al., (1971). Colorimetric determination of serum acid phosphatase activity using adenosine 3'-monophosphate as substrate. Journal of clinical pathology, 24(6), 493–500. [Content Brief]
- [3]. Jackson, E. K., et al., (2011). 2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. American journal of physiology. Heart and circulatory physiology, 301(2), H391–H401. [Content Brief]
