84-21-9
Chemical Structure
Adenosine 3′-monophosphate
Synonym(s): 3′-AMP
- CAS No.: 84-21-9
- Formula:C10H14N5O7P
- Molecular Weight:347.22
IUPAC Name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate
InChIKey: LNQVTSROQXJCDD-KQYNXXCUSA-N
SMILES: NC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C=N2)=NC=N1
Biological Activity: Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Adenosine 3′-monophosphate | 99% | Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. | ||||||||||||||||||||
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References
- [1]. S Ohkubo, et al. Effects of AMP derivatives on cyclic AMP levels in NG108-15 cells. Br J Pharmacol. 2000 Mar;129(6):1244-50. [Content Brief]
- [2]. Ellis, G., et al., (1971). Colorimetric determination of serum acid phosphatase activity using adenosine 3'-monophosphate as substrate. Journal of clinical pathology, 24(6), 493–500. [Content Brief]
- [3]. Jackson, E. K., et al., (2011). 2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. American journal of physiology. Heart and circulatory physiology, 301(2), H391–H401. [Content Brief]
