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immunodeficiency

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (107) Akt (1) Amyloid-β (1) Antibiotic (3) Apoptosis (8) Bacterial (9) Bcl-2 Family (2) Biochemical Assay Reagents (1) c-Kit (1) C-type Lectin-like Receptors (CTLRs) (1) CCR (3) CD19 (1) CMV (2) Complement System (2) CTLA-4 (1) CXCR (3) Cyclic GMP-AMP Synthase (1) Dengue Virus (2) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (4) Drug Intermediate (6) Drug Metabolite (1) EAAT (1) Endogenous Metabolite (3) ERK (1) Flavivirus (1) FLT3 (1) Fluorescent Dye (3) Fungal (1) Glucocorticoid Receptor (3) Glycosidase (1) HBV (4) HCV (1) HIV Integrase (10) HIV Protease (18) hnRNP (1) HPV (2) HSV (2) IFNAR (3) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (5) Liposome (1) Microtubule/Tubulin (1) Neurotensin Receptor (1) Nucleoside Antimetabolite/Analog (4) Opioid Receptor (1) p38 MAPK (1) Parasite (2) PI3K (4) PKC (2) Platelet-activating Factor Receptor (PAFR) (1) Progesterone Receptor (3) Pyroptosis (1) Reference Standards (7) Reverse Transcriptase (14) SARS-CoV (1) Sec61 (1) STAT (1) STING (1) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (2) VEGFR (2) VSV (2)
By Research Areas:	Cancer (23) Cardiovascular Disease (1) Infection (120) Inflammation/Immunology (36) Metabolic Disease (4) Neurological Disease (7)
Click Chemistry:	Azide (1)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (2) Nucleotide Analogs (1) CpG ODNs (3) Phospholipids (1) Antisense Oligonucleotides (1) Cytidine (1)

151

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: HIV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116282C

Dextran sulfate sodium salt (MW 35000-45000) 5+ Cited Publications DSS (MW 35000-45000); DXS (MW 35000-45000)	Apoptosis	Infection Inflammation/Immunology Cancer
Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .

HY-116282

Dextran sulfate sodium salt (MW 5000) 5 Publications Verification DSS (MW 5000); DXS (MW 5000)	HIV Complement System Apoptosis	Infection Inflammation/Immunology
Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .

HY-P0281

TAT TAT(47-57); HIV-1 TAT protein (47-57)	HIV	Infection
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins .

HY-116282A

Dextran sulfate sodium salt (MW 4500-5500) DSS (MW 4500-5500); DXS (MW 4500-5500)	HIV Apoptosis Complement System	Infection Inflammation/Immunology
Dextran sulfate sodium salt (DSS) (MW 4500-5500) is a polymer of dehydrated glucose with a molecular weight of approximately 4500-5500. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 4500-5500) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 4500-5500) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (MW 4500-5500) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 4500-5500) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) inhibits instant blood-mediated inflammatory reaction (IBMIR) .

HY-109137

Selgantolimod 1 Publications Verification GS-9688	Toll-like Receptor (TLR) HBV	Infection
Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection .

HY-17635

Leniolisib 1 Publications Verification CDZ173	PI3K	Inflammation/Immunology
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-126306

Deoxyfuconojirimycin hydrochloride	Glycosidase	Others
Deoxyfuconojirimycin hydrochloride is a highly specific α-L-fucosidase inhibitor, with a K_i value of 10 nM against human liver lysosomal α-L-fucosidase and a K_i value of 140 nM against Charonia lampas α-L-fucosidase. Deoxyfuconojirimycin hydrochloride completely inhibits the activity of all soluble α-L-fucosidases in human liver, including multiple post-translationally generated enzyme forms. Deoxyfuconojirimycin hydrochloride exhibits no anti-human immunodeficiency virus activity .

HY-N2575

Hypocrellin A 2 Publications Verification	PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis	Infection Metabolic Disease Cancer
Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC₅₀=0.27 μg/ml) .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Endogenous Metabolite DNA/RNA Synthesis	Cancer
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-129724A

α-MSH (11-13) acetate ACTH-(11-13) acetate; Lys-Pro-Val acetate; H-Lys-Pro-Val-OH acetate		Infection Metabolic Disease
α-MSH (11-13) acetate is a melanocortin-1 receptor ligand and anti-inflammatory agent. α-MSH (11-13) acetate triggers acute intracellular calcium elevation under specific costimulation or pathway inhibition conditions. α-MSH (11-13) acetate inhibits TNF-α-induced NF-κB activation, GPx activity, HIV replication, as well as colony formation of S. aureus and C. albicans. α-MSH (11-13) acetate is applicable to the research of Staphylococcus aureus infection, Candida albicans infection, human immunodeficiency virus infection, traumatic brain injury, corneal epithelial wound and inflammatory bowel disease .

HY-N2571

Corydine	Reverse Transcriptase HIV Opioid Receptor	Infection Neurological Disease Cancer
Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC₅₀ of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC₅₀ of 0.51 μM for MOR, and a K_i of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma .

HY-B1834

Megestrol	Progesterone Receptor Glucocorticoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause manifestations similar to those of glucocorticoids and increase the risk of mental disorders .

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-13269

BMS-707035 1 Publications Verification	HIV HIV Integrase	Infection Inflammation/Immunology
BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC₅₀ value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) .

HY-169848

(S)-Batylalcohol 1-O-Octadecyl-sn-glycerol	HIV	Infection
(S)-Batylalcohol (1-O-Octadecyl-sn-glycerol) is a phosphonoformic acid (PFA) analog that exhibits higher in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1) than PFA. (S)-Batylalcohol can be used in antiretroviral research .

HY-17635A

Leniolisib phosphate 1 Publications Verification CDZ173 phosphate	PI3K	Inflammation/Immunology
Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

HY-W251687

2'-Deoxy-2'-fluoroarabinoadenosine	Nucleoside Antimetabolite/Analog HIV	Infection
2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue, which exhibits anticancer activity against human immunodeficiency virus (HIV) .

HY-P0281A

TAT TFA TAT(47-57) TFA; HIV-1 TAT protein (47-57) TFA	HIV	Infection
TAT TFA (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins .

HY-P4125A

FITC-LC-TAT (47-57) acetate	HIV Fluorescent Dye	Others
FITC-LC-TAT (47-57) acetate is a FITC-labeled TAT peptide (HY-P0281) (λex: 493 nm, λem: 522 nm). Derived from the trans-activator of transcription (TAT) of immunodeficiency virus (HIV-1), TAT enhances the yield of heterologous proteins .

HY-P4122A

TAT (47-57), FAM-labeled acetate	HIV	Others
TAT (47-57), FAM-labeled acetate is a 5(6)-Carboxyfluorescein (HY-15940)-labeled TAT (HY-P0281). TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide .

HY-P4122

TAT (47-57), FAM-labeled	HIV	Others
TAT (47-57), FAM-labeled is a 5(6)-Carboxyfluorescein (HY-15940)-labeled TAT (HY-P0281). TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide .

HY-102026

Formycin A NSC 102811	HIV Nucleoside Antimetabolite/Analog Antibiotic	Infection Cancer
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent *human immunodeficiency* virus type 1 (HIV-1) inhibitor with an EC₅₀** of 10 μM. Formycin A shows antitumor and antiviral activities .

HY-106282

BIT-225	HIV	Infection
BIT-225 is an inhibitor for Vpu protein through block of Vpu ion channel, and thus inhibits the release of HIV-1, especially in monocyte-derived macrophages (EC₅₀ is 2.25 μM), without significant cytotoxicity (TC₅₀ is 284 μM) .

HY-19232

R-87366	HIV Protease	Inflammation/Immunology
R-87366 is a water-soluble *human immunodeficiency* virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a K_i** value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV) .

HY-150747

ODN 6016	IFNAR	Inflammation/Immunology
ODN 6016 is a CpG-A oligonucleotides. ODN 6016 can induce IFN-α production, can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .

HY-150747A

ODN 6016 sodium	IFNAR	Inflammation/Immunology
ODN 6016 sodium is a CpG-A oligonucleotides. ODN 6016 sodium can induce IFN-α production, and can be used for researching immune disorders including immunodeficiency caused by HIV-1. ODN 6016 sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G .

HY-105025A

Thymocartin TFA Thymopoietin II (32-35) TFA; TP 4 TFA	Apoptosis	Inflammation/Immunology
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025). Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals. Thymocartin TFA is potential for immunodeficiency diseases research .

HY-106382

PMEDAP	HIV CMV	Infection Cancer
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality .

HY-P4125

FITC-LC-TAT (47-57)	HIV Fluorescent Dye	Infection
FITC-LC-TAT (47-57) is a FITC-labeled TAT peptide (HY-P0281) (λex: 493 nm, λem: 522 nm). Derived from the trans-activator of transcription (TAT) of human immunodeficiency virus (HIV-1), TAT enhances the yield of heterologous proteins .

HY-148172

L-Fd4A	HIV HBV Nucleoside Antimetabolite/Analog	Infection
L-Fd4A is an adenine derivative. L-Fd4A has anti-*human immunodeficiency* virus (HIV) (EC₅₀=1.5 μM) and anti-hepatitis B virus (HBV) (EC₅₀**=1.7 μM) activity. L-Fd4A has low cytotoxicity .

HY-106395

Telinavir SC-52151	HIV Protease HIV	Infection
Telinavir (SC-52151) is a potent and selective HIV protease inhibitor. Telinavir inhibits lymphotropic, monocytotropic strains and field isolates of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus with EC₅₀s of 26 ng/mL (43 nM). Telinavir is highly protein bound in human plasma and exhibits low partitioning into erythrocytes .

HY-106958

Talviraline HBY 097	HIV Reverse Transcriptase	Infection
Talviraline is a non-nucleoside reverse transcriptase (NNRT) inhibitor that is primarily used to inhibit the replication of human immunodeficiency virus type 1 (HIV-1). Talviraline inhibits the viral replication process by binding to a specific site of HIV-1 reverse transcriptase (RT). Talviraline can be used to study the potential countermeasures and safety of HIV-1 infection .

HY-14891

Fosdevirine GSK2248761; FDV	HIV Reverse Transcriptase	Infection
Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572)-resistant clinical isolates .

HY-131607

Carbovir triphosphate CBV-TP; (-)-Carbovir triphosphate; (-)-Carbovir 5′-triphosphate	HIV	Infection Inflammation/Immunology
Carbovir triphosphate (CBV-TP) is a phosphorylated metabolite. Carbovir triphosphate can be used for the research of human immunodeficiency virus (HIV) .

HY-P4015

VIP (1-12), human, porcine, rat, ovine	HIV	Neurological Disease Metabolic Disease
VIP (1-12), human, porcine, rat, ovine is a vasoactive intestinal peptide (VIP) fragment. VIP (1-12), human, porcine, rat, ovine is a ligand for the CD4 (T4)/human immunodeficiency virus receptor .

HY-17635S

Leniolisib-d5 CDZ173-d₅	Isotope-Labeled Compounds PI3K	Inflammation/Immunology
Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-N1034

12-Oxocalanolide A (±)-12-Oxocalanolide A	HIV	Infection
12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide .

HY-105025

Thymocartin Thymopoietin II (32-35); TP 4	Apoptosis	Inflammation/Immunology
Thymocartin (Thymopoietin II (32-35)) is the 32-35 fragment of the thymic factor (thymopoietin). Thymocartin has shown potential for immunodeficiency diseases research .

HY-100212

JE-2147 AG1776; KNI-764	HIV HIV Protease	Infection
JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a K_i of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro .

HY-P2251

T-peptide	HIV Microtubule/Tubulin	Infection Inflammation/Immunology Cancer
T-peptide, a Tuftsin analog, can be used for the research of *human immunodeficiency* virus (HIV)** infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection .

HY-P35433

Tifuvirtide T-1249	HIV	Inflammation/Immunology
Tifuvirtide (T-1249) is a peptide *human immunodeficiency* virus type-1 (HIV-1)** fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .

HY-144286

CXCR4 antagonist 3	CXCR	Infection
CXCR4 antagonist 3 (compound 12a) is a potent antagonist of CXCR4 with an IC₅₀ of 11 nM. CXCR4 antagonist 3 is a congener of TIQ15. CXCR4 antagonist 3 demonstrates the best overall properties including CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. CXCR4 antagonist 3 has the potential for the research of human immunodeficiency virus .

HY-19194

A-80987	HIV Protease	Infection
A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .

HY-14135

BMS 488043 BMS 043	HIV	Infection Inflammation/Immunology
BMS 488043 (BMS 043) is an orally active and well-tolerated inhibitor of the attachment of human immunodeficiency virus type 1 (HIV-1) to CD4+ lymphocytes .

HY-178201

JLJ648	HIV Pyroptosis	Infection
JLJ648 is a Gag-Pol dimerizer with antiviral activity. JLJ648 can inhibit HIV replication and induce infected cell pyroptosis. JLJ648 can be used for the research of infection, such as HIV (human immunodeficiency virus) .

HY-16907

GSK-364735 S/GSK-364735	HIV HIV Integrase	Infection
GSK-364735 is a potent antiretroviral agent against human immunodeficiency virus type 1 (HIV-1) and serves as an integrase inhibitor with an IC₅₀ of 8 ± 2 nM. GSK-364735 can be utilized in antiviral research .

HY-P0281B

TAT acetate TAT(47-57) acetate; HIV-1 TAT protein (47-57) acetate	HIV	Infection
TAT (TAT(47-57)) acetate is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT acetate can increase the yields and the solubility of heterologous proteins .

HY-144285

CXCR4 antagonist 4	CXCR HIV	Inflammation/Immunology
CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC₅₀=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC₅₀=7 nM) .

HY-P1753

VIR-165	HIV	Infection
VIR-165 is a modified form of virus inhibitory peptide (VIRIP) that binds the fusion peptide of the gp41 subunit and prevents its insertion into the target membrane. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains .

HY-139158

Ainuovirine	HIV	Infection
Ainuovirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Ainuovirine inhibits HIV replication by non-competitively binding to HIV reverse transcriptase and blocking the reverse transcription process of viral RNA. Ainuovirine can be used for human immunodeficiency virus (HIV) type 1 infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0281

TAT TAT(47-57); HIV-1 TAT protein (47-57)	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	HIV
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins .

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N2575

Hypocrellin A 2 Publications Verification	Infection Quinones Structural Classification Microorganisms other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis
Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC₅₀=0.27 μg/ml) .

HY-N0165

Methyl-Hesperidin	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HIV Reverse Transcriptase
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-N2571

Corydine	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Reverse Transcriptase HIV Opioid Receptor
Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC₅₀ of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC₅₀ of 0.51 μM for MOR, and a K_i of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma .

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N2188

Beta-Acetoxyisovalerylshikonin 1 Publications Verification	Structural Classification Classification of Application Fields Plants Naphthalene Quinones Boraginaceae Quinones other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Arnebia euchroma (Royle) Johnst. Source Classification	HIV
Beta-Acetoxyisovalerylshikonin is a naturally occurring naphthoquinone-type shikonin derivative that is widely distributed in the roots and cell suspension cultures of Arnebia euchroma, Arnebia guttata, Onosma hispidum and Lithospermum erythrorhizon. Beta-Acetoxyisovalerylshikonin exhibits favorable antibacterial, anti-inflammatory, wound-healing promoting and antioxidant activities, and also possesses potential anti-tumor and anti-HIV properties .

HY-N5178

Chloropeptin I	Natural Products Microorganisms Source Classification	HIV
Chloropeptin I inhibits the binding of gp120 to CD4 with IC₅₀ of 2.0 μM, with the activity of selective anti-*human immunodeficiency* virus (HIV)** .

HY-N14095

Curromycin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial HIV
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-N14110

Curromycin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial HIV
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of *human immunodeficiency* virus (HIV)**, inhibit mouse melanoma B16 and leukemia P388 cells .

HY-N12905

Celastramycin A (isomer)	Microorganisms Phenols Polyphenols Source Classification	Antibiotic Bacterial
Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL .

HY-N2575R

Hypocrellin A (Standard)	Structural Classification Natural Products Microorganisms other families Phenols Polyphenols Plants Source Classification	Reference Standards PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis
Hypocrellin A (Standard) is the analytical standard of Hypocrellin A. This product is intended for research and analytical applications. Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml)[1][2][3][4][5][6][7][8][9].

HY-N11939

Kadsuralignan A	Schisandra lancifolia (Rehd. et Wils.) A. C. Smith Lignans Phenylpropanoids Plants Schisandraceae Source Classification	HIV
Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with EC₅₀=2.23 μg/mL .

HY-17431R

Fosamprenavir Calcium Salt (Standard) GW433908G (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) (Standard) is the analytical standard of Fosamprenavir Calcium Salt (HY-17431R). This product is intended for research and analytical applications. Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .

Cat. No.	Product Name	Chemical Structure

HY-17635S

Leniolisib-d5
Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

HY-78726S

Fosamprenavir-d4

Fosamprenavir-d₄ is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-W747043

Megestrol-d3
Megestrol-d₃ is the deuterium labeled Megestrol (HY-B1834). Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis .

HY-B1834S1

Megestrol-d5
Megestrol-d₅ is the deuterium labeled Megestrol. Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause glucocorticoid-like effects and an increased risk of mental disorders.

HY-78726S2

Fosamprenavir-13C6

Fosamprenavir- ¹³C₆ is the ¹³C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

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