2. PI3K/Akt/mTOR
  3. PI3K
  4. Leniolisib phosphate

Leniolisib phosphate  (Synonyms: CDZ173 phosphate)

Cat. No.: HY-17635A Purity: 99.10%
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Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

For research use only. We do not sell to patients.

Leniolisib phosphate Chemical Structure

Leniolisib phosphate Chemical Structure

CAS No. : 1354691-97-6

Size Price Stock Quantity
1 mg USD 90 In-stock
5 mg USD 210 In-stock
10 mg USD 350 In-stock
25 mg USD 735 In-stock
50 mg USD 1200 In-stock
100 mg USD 2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Leniolisib phosphate:

Leniolisib phosphate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Leniolisib phosphate

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.

IC50 & Target[1]

PI3Kδ

11 nM (IC50)

PI3Kα

280 nM (IC50)

PI3Kβ

480 nM (IC50)

PI3Kγ

2.57 nM (IC50)

DNA-PK

880 nM (IC50)

In Vitro

Expression of APDS mutant p110δ in cell lines and patient-derived lymphocytes lead to increased pathway activity, measured as phosphorylation of AKT or S6, which is suppressed by Leniolisib phosphate in a concentration dependent way[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leniolisib phosphate Related Antibodies
Clinical Trial
Molecular Weight

548.45

Formula

C21H28F3N6O6P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCC(N1C[C@H](CC1)NC2=C3CN(CCC3=NC=N2)C4=CC(C(F)(F)F)=C(N=C4)OC)=O.O=P(O)(O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (182.33 mM; Need ultrasonic)

DMSO : 100 mg/mL (182.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8233 mL 9.1166 mL 18.2332 mL
5 mM 0.3647 mL 1.8233 mL 3.6466 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.8233 mL 9.1166 mL 18.2332 mL 45.5830 mL
5 mM 0.3647 mL 1.8233 mL 3.6466 mL 9.1166 mL
10 mM 0.1823 mL 0.9117 mL 1.8233 mL 4.5583 mL
15 mM 0.1216 mL 0.6078 mL 1.2155 mL 3.0389 mL
20 mM 0.0912 mL 0.4558 mL 0.9117 mL 2.2792 mL
25 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.8233 mL
30 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5194 mL
40 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1396 mL
50 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.9117 mL
60 mM 0.0304 mL 0.1519 mL 0.3039 mL 0.7597 mL
80 mM 0.0228 mL 0.1140 mL 0.2279 mL 0.5698 mL
100 mM 0.0182 mL 0.0912 mL 0.1823 mL 0.4558 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Leniolisib phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leniolisib1354691-97-6CDZ173CDZ 173CDZ-173PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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