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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
intracellular Ca2+ influx
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "intracellular Ca2+ influx" in MCE Product Catalog:
40
40 Publications Verification
Cat. No.: HY-19608
CAS No.: 942206-85-1
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GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca 2+ influx and elevate intracellular Ca 2+ in HEK cells .
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Alkaloids Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields Isoquinoline Alkaloids
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Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Convolvulaceae Ipomoea batatas (Linn.) Lamarck
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Synonyms: N-FMOC-leucine; NPC 15199; NSC 334290
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Fmoc-Leucine (N-FMOC-leucine) is an anti-inflammatory agent that not only promotes extracellular Ca 2+ influx but also facilitates intracellular Ca 2+ release. Fmoc-Leucine is a selective ligand for PPARγ (Ki = 15 μM), exhibiting insulin-sensitizing effects but with weak fatogenic activity. Fmoc-Leucine exhibits unique self-assembly properties and can form transient gels, stable gels, or crystals/2D sheets through different pathways. Fmoc-Leucine can be used in the research of diabetes, colitis, and bladder cancer .
Cat. No.: HY-N7875
CAS No.: 116159-73-0
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Cat. No.: HY-111198
CAS No.: 887647-69-0
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YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively .
Synonyms: Riparin III
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Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca 2+ influx and inhibiting the release of intracellular calcium ion stores .
Cat. No.: HY-100168R
CAS No.: 85233-19-8
Cat. No.: HY-105521A
CAS No.: 94096-42-1
Synonyms: (S)-Nafenodone; LU-43706
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Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na + current and slow inward Ca 2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca 2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca 2+ stores, suppresses agonist-stimulated Ca 2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression .
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Cat. No.: HY-100168AR
CAS No.: 126824-24-6
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BAPTA tetrasodium (Standard) is the analytical standard of BAPTA tetrasodium. This product is intended for research and analytical applications. BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
Cat. No.: HY-106837
CAS No.: 117279-73-9
Synonyms: Y 24180
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Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca 2+ influx and intracellular Ca 2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice .
Cat. No.: HY-13764A
CAS No.: 23495-89-8
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Alkaloids Stephania japonica var. discolor (Blume) Forman Plants Menispermaceae Alkaloid Dimers
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Cat. No.: HY-E71616
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2'-Phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC 2.4.99.20) catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes.
Cat. No.: HY-19608R
CAS No.: 942206-85-1
Research Areas:
GSK1016790A (Standard) is the analytical standard of GSK1016790A (HY-19608). This product is intended for research and analytical applications. GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca 2+ influx and elevate intracellular Ca 2+ in HEK cells .
Cat. No.: HY-105521
CAS No.: 92629-87-3
Synonyms: (S)-Nafenodone free base; LU-43706 free base
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Dexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na + current and slow inward Ca 2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca 2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca 2+ stores, suppresses agonist-stimulated Ca 2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression .
Cat. No.: HY-100168BR
CAS No.: 73630-08-7
Cat. No.: HY-184055
CAS No.: 2643356-08-3
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NMDA receptor antagonist-12 (Example 17) is an antagonist of NMDA receptors containing the NR2B subunit. NMDA receptor antagonist-12 exerts antagonistic effects on NMDA receptors containing the NR2B subunit and blocks the intracellular Ca 2+ influx mediated by these receptors. NMDA receptor antagonist-12 can be used in research related to diseases such as depression, bipolar disorder, migraine, and pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
