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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
kidney-type
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "kidney-type" in MCE Product Catalog:
116
116 Publications Verification
Synonyms: CB-839
Target:
Research Areas:
Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .
116
116 Publications Verification
Cat. No.: HY-12248A
CAS No.: 1874231-60-3
Synonyms: CB-839 hydrochloride
Target:
Research Areas:
Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity .
2
2 Cited Publications
Cat. No.: HY-P7880
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ALPL; Alkaline Phosphatase, Liver/Bone/kidney; Prev. HOPS; TNS-ALP; TNSALP; Liver/Bone/kidney-type Alkaline Phosphatase; Alkaline Phosphatase, Tissue-Nonspecific Isozyme; Tissue-Nonspecific ALP; Alkaline Phosphatase Liver/Bone/kidney Isozyme; Alkaline Pho
Species:
Human
Source:
HEK293
1
1 Cited Publications
Synonyms: CB839 derivative
Target:
Research Areas:
Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
Cat. No.: HY-12248R
CAS No.: 1439399-58-2
Synonyms: CB-839 (Standard)
Target:
Research Areas:
Telaglenastat (Standard) is the analytical standard of Telaglenastat. This product is intended for research and analytical applications. Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .
Cat. No.: HY-158378
CAS No.: 3058726-63-6
Synonyms: R-AST-OH
Target:
Research Areas:
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy .
Cat. No.: HY-P7603
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ARG2; type II Arginase; Arginase 2; Arginase II; Arginase-2, Mitochondrial; L-Arginine Amidinohydrolase; kidney-type Arginase; L-Arginine Ureahydrolase; Non-Hepatic Arginase; Nonhepatic Arginase; Arginase, type II; kidney Arginase
Species:
Human
Source:
E. coli
Cat. No.: HY-P72090
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ARG2; type II Arginase; Arginase 2; Arginase II; Arginase-2, Mitochondrial; L-Arginine Amidinohydrolase; kidney-type Arginase; L-Arginine Ureahydrolase; Non-Hepatic Arginase; Nonhepatic Arginase; Arginase, type II; kidney Arginase
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P705455
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ARG2; type II Arginase; Arginase 2; Arginase II; Arginase-2, Mitochondrial; L-Arginine Amidinohydrolase; kidney-type Arginase; L-Arginine Ureahydrolase; Non-Hepatic Arginase; Nonhepatic Arginase; Arginase, type II; kidney Arginase
Species:
Human
Source:
E. coli
Cat. No.: HY-P74415
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ALPL; Alkaline Phosphatase, Liver/Bone/kidney; Prev. HOPS; TNS-ALP; TNSALP; Liver/Bone/kidney-type Alkaline Phosphatase; Alkaline Phosphatase, Tissue-Nonspecific Isozyme; Tissue-Nonspecific ALP; Alkaline Phosphatase Liver/Bone/kidney Isozyme; Alkaline Pho
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74416
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ALPL; Alkaline Phosphatase, Liver/Bone/kidney; Prev. HOPS; TNS-ALP; TNSALP; Liver/Bone/kidney-type Alkaline Phosphatase; Alkaline Phosphatase, Tissue-Nonspecific Isozyme; Tissue-Nonspecific ALP; Alkaline Phosphatase Liver/Bone/kidney Isozyme; Alkaline Pho
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P705498
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ALPL; Alkaline Phosphatase, Liver/Bone/kidney; Prev. HOPS; TNS-ALP; TNSALP; Liver/Bone/kidney-type Alkaline Phosphatase; Alkaline Phosphatase, Tissue-Nonspecific Isozyme; Tissue-Nonspecific ALP; Alkaline Phosphatase Liver/Bone/kidney Isozyme; Alkaline Pho
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P704350
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ALPL; Alkaline Phosphatase, Liver/Bone/kidney; Prev. HOPS; TNS-ALP; TNSALP; Liver/Bone/kidney-type Alkaline Phosphatase; Alkaline Phosphatase, Tissue-Nonspecific Isozyme; Tissue-Nonspecific ALP; Alkaline Phosphatase Liver/Bone/kidney Isozyme; Alkaline Pho
Species:
Human
Source:
HEK293
Cat. No.: HY-P86653
Synonyms: ALPL; AKP2; Alkaline phosphatase liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase tissue nonspecific isozyme; AP TNAP; AP-TNAP; APTNAP; BALP; BAP; FLJ40094; FLJ93059; Glycerophosphatase; HOPS; Liver/bone/kidney isozyme; Liver/bone/kidney type alkaline phosphatase; MGC161443; MGC167935; PHOA; PPBT_HUMAN; Tissue non specific alkaline phosphatase; Tissue nonspecific ALP; TNAP; TNSALP.
Cat. No.: HY-P86653A
Synonyms: ALPL; AKP2; Alkaline phosphatase liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase tissue nonspecific isozyme; AP TNAP; AP-TNAP; APTNAP; BALP; BAP; FLJ40094; FLJ93059; Glycerophosphatase; HOPS; Liver/bone/kidney isozyme; Liver/bone/kidney type alkaline phosphatase; MGC161443; MGC167935; PHOA; PPBT_HUMAN; Tissue non specific alkaline phosphatase; Tissue nonspecific ALP; TNAP; TNSALP.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
