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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
lipoteichoic acid biosynthesis
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "lipoteichoic acid biosynthesis" in MCE Product Catalog:
Target:
Research Areas:
HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model .
Cat. No.: HY-189221
Antimicrobial agent-56 is an antimicrobial agent that targets the cell membrane of drug-resistant bacteria. Antimicrobial agent-56 disrupts the cell membrane integrity of methicillin-resistant Staphylococcus aureus (MRSA) via membrane targeting, downregulates lipoteichoic acid biosynthesis and two-component system signaling, inhibits MRSA biofilm formation and eradicates mature biofilms, with a MIC of 6.25 μg/mL. Antimicrobial agent-56 hardly induces drug resistance, exhibits low hemolytic activity, inhibits NO production stimulated by LPS (HY-D1056), and retains the anti-inflammatory activity of Resveratrol (HY-16561). Antimicrobial agent-56 loaded in PVA-SA hydrogel promotes the healing of MRSA-infected wounds and suppresses inflammation. Antimicrobial agent-56 can be used in studies related to MRSA infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
